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您的检索式：作者名="Libai Yang"
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| 1 | Anomalous expression of chloride transporters in the sclerosed hippocampus of mesial temporal lobe epilepsy patients显示文摘The Na+-K+-Cl-cotransporter 1 and K+-Cl-cotransporter 2 regulate the levels of intracellular chloride in hippocampal cells.Impaired chloride transport by these proteins is thought to be involved in the pathophysiological mechanisms of mesial temporal lobe epilepsy.Imbalance in the relative expression of these two proteins can lead to a collapse of Cl-homeostasis,resulting in a loss of gamma-aminobutyric acid-ergic inhibition and even epileptiform discharges.In this study,we investigated the expression of Na+-K+-Cl-cotransporter 1 and K+-Cl-cotransporter 2 in the sclerosed hippocampus of patients with mesial temporal lobe epilepsy,using western blot analysis and immunohistochemistry.Compared with the histologically normal hippocampus,the sclerosed hippocampus showed increased Na+-K+-Cl-cotransporter 1 expression and decreased K+-Cl-cotransporter 2 expression,especially in CA2 and the dentate gyrus.The change was more prominent for the Na+-K+-Cl-cotransporter 1 than for the K+-Cl-cotransporter 2.These experimental findings indicate that the balance between intracellular and extracellular chloride may be disturbed in hippocampal sclerosis,contributing to the hyperexcitability underlying epileptic seizures.Changes in Na+-K+-Cl-cotransporter 1 expression seems to be the main contributor.Our study may shed new light on possible therapies for patients with mesial temporal lobe epilepsy with hippocampal sclerosis. | Xiaodong Cai Libai Yang Jueqian Zhou Dan Zhu Qiang Guo Ziyi Chen Shuda Chen Liemin Zhou | 2013 | Neural Regeneration Research2013，8，6： | 2 |
| 2 | Supramolecular Vesicles Based on Water-Soluble 2,6-Helic[6]arene:High Affinity Binding,Stimuli Responsiveness and Delivery of Doxorubicin to Cancer Cells显示文摘Water-soluble 2,6-helic[6]arene was used to construct supramolecular vesicles via host-guest interaction. Water-soluble 2,6-helic[6]arene was discovered to be high affinity host for suitable biomarkers. Supramolecular vesicles were responsive to multiple stimuli types, including temperature, pH, Ca^2+, CO2 bubbling and biomarker displacement. Supramolecular vesicles were used to load and deliver anti-tumor drug doxorubicin to HeLa cells in vitro. | Xuan Yang Weipeng Mao Yamin Liu Libai Li Da Ma | 2019 | Chinese Journal of Chemistry2019，37，6： | 1 |
| 3 | Dynamic expression of P-glycoprotein in the CA1,CA3 and dentate gyrus of the rat hippocampus following lithium-pilocarpine-induced status epilepticus显示文摘Epileptic seizures induce overexpression of P-glycoprotein in the blood-brain barrier. However,it is unclear whether hippocampal neurons also overexpress P-glycoprotein following seizure. This study confirmed that the clinical manifestation,pathological characteristics and electroencephalography in the rat model of lithium-pilocarpine-induced mesial temporal lobe epilepsy were consistent with clinical reports of mesial temporal lobe epilepsy in humans. Immunohistochemistry staining demonstrated that P-glycoprotein positive staining was found in neurons in the pyramidal layer of the hippocampus. Western blot assay and real-time polymerase chain reaction revealed that P-glycoprotein overexpression was exhibited in the CA1,CA3,and dentate gyrus of the hippocampus at 24 and 60 days following model induction,but no significant difference was detected in the same region at various time points. These results indicate that seizures led to overexpression of P-glycoprotein in neurons of the hippocampus,but no evidence was found for a positive association between P-glycoprotein expression and seizure frequency. | Shuda Chen Jueqian Zhou Xiuling Liang Ziyi Chen Libai Yang Liemin Zhou | 2010 | Neural Regeneration Research2010，5，24： | 1 |
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