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| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Stepwise approach to substrate modification of ventricular tachycardia after myocardial infarction显示文摘背景最近,(SM ) 底层印射被描述了在心肌的梗塞以后便于稳定、不稳定的室的心悸亢进(vt ) 的导管脱离。然而, SM 与象室的功能或专业版心律不齐的缺陷那样的多重脱离线的潜在的劣势是耗时的。现在的学习的目的是描出 SM 的一条逐步的途径弄短过程时间和限制复杂并发症的可能性。方法 SM 在幸存者们用一个 electroanatomicalmapping 系统(CARTO ) 为 vt 脱离提交了定义梗塞区域的 14 梗塞被执行。为 SM 的一条新逐步的途径如下被设计。起始的脱离地点被步识别 -- 并且在稳定的 vt 的情况下并且由步仅仅在不稳定的 vt 的情况下印射印射的乘火车。基于印射的 CARTO 电压,线性脱离从这个地点被做到疤的中心并且对 thes 汽车的边界或到僧帽形的体环垂直。仅仅当 vt 仍然保持可诱导时,另外的线被执行。3 根脱离线的 Amaximum 在一个过程期间被创造。57 vt 全部的结果 A (21 马厩, 36 不稳定) 在过程期间被导致。vt 在在 2 个病人的第一线性脱离以后不再是可诱导的,在在 6 个病人的第二线性脱离以后并且在在 3 个病人的第三线性脱离以后。vt 或室的纤维性颤动在在 3 个病人的过程的结束仍然是可诱导的。平均的过程时间(291 ± 8 5 ) 分钟,荧光检查时间(10 ± 7 ) 纪录。vt 在 3 个病人复发了。在 2 个病人跟随第二个过程,没有进一步的 vt 复发。总的来说,在 vt 事件有重要减小 3 个月在以后[中部:0,内部方照范围(IQR ) :0-1 ] 与在脱离前的 3 个月相比(中部:25, IQR:16-105, P <
0.01 ) 。结论 SM 的这条逐步的途径在便于稳定、不稳定的 vt 的脱离是有效的。它减少过程和荧光检查预定,并且可以帮助改进 vt 的风险利益比率脱离。 | LI Yi-gang Gerian Groenefeld Carsten Israel LU Shang-biao WANG Qun-shan MENG Shu Stefan H Hohnloser | 2006 | Chinese Medical Journal2006，，14： | 3 |
| 3 | Antipsychotic Medications in Major Depression and the Association with Treatment Satisfaction and Quality of Life: Findings of Three National Surveys on Use of Psychotropics in China Between 2002 and 2012显示文摘 | Yu-Xi Wang Yu-Tao Xiang Yun-Ai Su Qian Li Liang Shu Chee H Ng Gabor S Ungvari Helen FK Chiu Yu-Ping Nin Gao-Hua Wang Pei-Shen Bai Tao Li Li-Zhong Sun Jian-Guo Shi Xian-Sheng Chen Qi-Yi Mei Ke-Qing Li Xin Yu Tian-Mei Si | 2015 | Chinese Medical Journal2015，，14： | 2 |
| 4 | Influence of the Reynolds number on chaotic mixing in a spatially periodic micromixer and its characterization using dynamical system techniques 显示文摘 | XIA H M SHU C WAN Y M | 2006 | Journal of Micromechanics and Microengineering2006，16，1： | 1 |
| 5 | Anatomic study and review of the literature on the Martin-Gruber anastomosis显示文摘 | Shu H Chantelot C Oberlin C | 1999 | Morphologie1999，83，260： | 1 |
| 6 | Free vibration analysis of curvilinear quadrilateral plates by the differential quadrature method显示文摘 | Shu C Chen W Du H | 2000 | J Comput Phys2000，163，2： | 1 |
| 7 | Fluoride and aluminum concentration of tea plants and tea product from Sichuan Province PR China显示文摘 | Shu W S Zhang L Y Wong M H | 2003 | Chemosphere2003，52，9： | 1 |
| 8 | TALL-1 is a novel member of the TNF family that is down-regulated by mitogens显示文摘 | Shu H B Hu W H Johnson H | 1999 | J Leukoc Biol1999，65，5： | 1 |
| 9 | Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway 显示文摘 | Jiang X Kim HE Shu H | 2003 | Science2003，299，5604： | 1 |
| 10 | A prospective studyof dietary patterns and mortality in Chinese women 显示文摘 | Cai H Shu XO Gao YT | 2007 | Epidemiology2007，18，： | 1 |
| 11 | Expression of multidrug resist anc-related proteins P-glycoprotein,glutathione-Stransfera ses,topoisomerase-and lung resistance protein in primary gastric cardiac adenocarcinoma显示文摘 | Shi H Lu D Shu Y | 2008 | Hepato gastroenterology2008，55，8687： | 1 |
| 12 | Effect of high pres sure versus conventional thawing on color, drip loss and texture of Atlantic salmon frozen by different methods 显示文摘 | Zhu Shu Ramaswamy H S Simpson B K | 2004 | LWT-Food Science and Technology2004，37，3： | 1 |
| 13 | Effect of Fe3 04 addition on removal of ammonium by zeolite NaA 显示文摘 | LIU H B PENG S C SHU L | 2013 | Journal of Colloid and Interface Science2013，390，1： | 1 |
| 14 | A lattice Boltzmann model for muhiphase flows with large density ratio显示文摘 | Zheng H W Shu C Chew Y T | 2006 | J Comput Phys2006，218，： | 1 |
| 15 | Antioxidant properties of hot water extracts from agrocybe cylindracea 显示文摘 | Shu Y T Shih J H Jeng L M | 2006 | Food Chemistry2006，98，6： | 1 |
| 16 | Studies of rapidly disintegrating tablets in the oral cavity using co-ground mixtures of mannitol with crospovidone 显示文摘 | Shu T Suzuki H Hironaka K | 2002 | Chem Pharm Bull(Tokyo)2002，50，2： | 1 |
| 17 | Probable limited person-to person transmission of highly pathogenic avian influenza A (H5N1) virus in China显示文摘 | Wang H Feng Z Shu Y | 2008 | Lancet2008，371，： | 1 |
| 18 | Effect of Ag on the aging characteristics of Cu-Fe in situ composites 显示文摘 | Gao H Y Wang J Shu D | 2006 | Scripta Materialia2006，54，11： | 1 |
| 19 | Atmospheric lifetimes and fates of a series of sesquiterpenes 显示文摘 | Shu Y H Atkinson R | 1995 | Journal of Geophysical Research- atmospheres1995，100，4： | 1 |
| 20 | Reveled refinement study of the pressuredependence of the internal structural parameter u in the wurtzite phase of ZnO显示文摘 | Liu H Ding Y Somayazulu M Leian J Shu J Husermann D Mao H K | 2005 | Phys Rev B2005，71，21： | 1 |
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