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	题名	作者	年代	出处	被引量
1	Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides.	John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin	2015	World Journal of Gastroenterology2015，21，35：	3
2	Outcome prediction of emergency patients by noninvasive hemodynamic monitoring显示文摘	Shoemaker W C Wo C C Ramicone E	2001	Chest2001，120，：	2
3	A new integrated genetic linkage map of the soybean显示文摘	Song Q J Marek L F Shoemaker R C	2004	Theoretial and Applied Genetics2004，109，：	1
4	Production and processing of milk from transgenic goats expressing human lysozyme in the mammary gland 显示文摘	MAGA E A SHOEMAKER C F ROWE J D	2006	Journal of Dairy Science2006，89，2：	1
5	Design and testing of PCR primers for the construction of scFv libraries representing the immunoglobulin repertoire of rats显示文摘	Sepulveda J Shoemaker C B	2008	J Immunol Methods2008，332，12：	1
6	A new integrated ge-netic linkage map of the soybean显示文摘	Song Q J Marek L F Shoemaker R C	2004	Theoretical and Applied Ge-netics2004，109，：	1
7	Evaluation of a loop- mediated isothermal amplification method for rapid detection of channel fish Ictalurus punctatus important bacterial pathogen Edwar dsiella ictaluri显示文摘	Yeh H Y Shoemaker C A Klesius P H	2005	J Microbiol Methods2005，63，：	1
8	Analysis of a quantitative trait locus allele from wild soybean that increases seed protein concentration in soybean显示文摘	Sebolt A M Shoemaker R C Diers B W	2000	Crop Science2000，40，5：	1
9	Lunar surface topography显示文摘	Rennilson J J Dragg J L Morris E C Shoemaker E M Turkevich A	1966	Surveyor I mission report part Ⅱ:Scientific data and results NASA JPL Technical Report1966，32，：	1
10	Efficacy of Strepto~occus agalactiae ( group B ) vaccine in tilapia ( Oreochromis nilotlcus) by intraperitoneal and bath immersion administration 显示文摘	Evans J J Klesius P H Shoemaker C A	2004	Vaccine2004，22，2728：	1
11	Integration of simple sequence repeat DNA markers into a soybean linkage map 显示文摘	Akkaya M S Shoemaker R C Specht J E	1995	Crop Sci1995，35，5：	1
12	Genomic organization of glycinin genes in soybean显示文摘	Beilinson V Chen Z Shoemaker R C	2002	Theoretical and Applied Genetics2002，104，67：	1
13	ABT-263:A Potent and orally bioavailable Bcl-2 family inhibitor显示文摘	Tse C Shoemaker AR Adickes J	2008	Cancer Research2008，68，9：	1
14	Phylogenetic Utility of Histone H3 Intron Sequences in the Perennial Relatives of Soybean(Glycine:Leguminosae)显示文摘	Doyle J J Kanazin V Shoemaker R C	1996	Mol Phylogenet Evol1996，6，：	1
15	显示文摘	Proell W A Adams C E Shoemaker B H	1948	Ind Eng Chem1948，40，：	1
16	A new integrated genetic linkage map of the soybean 显示文摘	Song Q J Marek L F Shoemaker R C	2004	Theoretical and App lied Genetics2004，109，1：	1
17	Transmission and detection of Flavobacterium columnare in channel catfish Ictalurus punctatu 显示文摘	Welker T L Shoemaker C A Arias C R	2005	Dis Aquat Organ2005，63，23：	1
18	Methodology for analyzing ranges of uncertain model parameters and their impact on total maximum daily load process 显示文摘	Benaman J Shoemaker C A	2004	Journal of Environmental Engineering2004，130，6：	1
19	Isolation and characterization of genomic and cDNA clones of human erythropoietin显示文摘	Jacobs K Shoemaker C Rudersdorf R	1985	Nature1985，313，6005：	1
20	Resistance gene analogs are conserved and clustered in soybean 显示文摘	Kanazin V Marek L F Shoemaker R C	1996	Proceedings of the National Academy of Sciences of the USA1996，93，11：	1

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