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| 1 | Wound healing of intestinal epithelial cells显示文摘The intestinal epithelial cells(IECs) form a selective permeability barrier separating luminal content from underlying tissues.Upon injury,the intestinal epithelium undergoes a wound healing process.Intestinal wound healing is dependent on the balance of three cellular events;restitution,proliferation,and differentiation of epithelial cells adjacent to the wounded area.Previous studies have shown that various regulatory peptides,including growth factors and cytokines,modulate intestinal epithelial wound healing.Recent studies have revealed that novel factors,which include toll-like receptors(TLRs),regulatory peptides,particular dietary factors,and some gastroprotective agents,also modulate intestinal epithelial wound repair.Among these factors,the activation of TLRs by commensal bacteria is suggested to play an essential role in the maintenance of gut homeostasis.Recent studies suggest that mutations and dysregulation of TLRs could be major contributing factors in the predisposition and perpetuation of inflammatory bowel disease.Additionally,studies have shown that specific signaling pathways are involved in IEC wound repair.In this review,we summarize the function of IECs,the process of intestinal epithelial wound healing,and the functions and mechanisms of the various factors that contribute to gut homeostasis and intestinal epithelial wound healing. | Masahiro Iizuka Shiho Konno | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 2 | A new index for non-invasive assessment of liver fibrosis显示文摘AIM:To construct and evaluate a new non-invasive fibrosis index for assessment of the stage of liver f ibrosis. METHODS:A new f ibrosis index (Fibro-Stiffness index) was developed in 165 of 285 patients with chronic hepatitis C, and was validated in the other 120 patients where liver biopsy was performed. Its usefulness was compared with liver stiffness (LS) measured by FibroScan, the aminotransferase-to-platelet ratio index, the Forns index and the FibroIndex. RESULTS: The Fibro-Stiffness index consists of LS,platelet count and prothrombin time. The values of the Fibro-Stiffness index differed signif icantly between neighboring f ibrosis stages except F0-F1. The area under the receiver operating characteristics curves of the Fibro-Stiffness index for prediction of F≥2 (0.90), F≥ 3 (0.90) and F= 4(0.92) in the estimation group and those for F≥ 3 (0.93) and F =4 (0.97) in the validation group were the highest among the 5 methods examined. The accuracy of the Fibro-Stiffness index had highest values for F≥2, F≥3 and F=4 in both the estimation and validation groups. The diagnostic performance for F= 4 was improved by a combination of the Fibro-Stiffness index with serum hyaluronic acid level. CONCLUSION: The Fibro-Stiffness index was constructed and validated. It showed superior diagnostic performance to other indices for F ≥ 2,3 and 4. | Naohiro Ichino Keisuke Osakabe Toru Nishikawa Hiroko Sugiyama Miho Kato Shiho Kitahara Senju Hashimoto Naoto Kawabe Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Yuko Arima Hiroaki Shimazaki Koji Suzuki Kentaro Yoshioka | 2010 | World Journal of Gastroenterology2010，16，38： | 7 |
| 3 | Hemorrhagic shock due to submucosal esophageal hematoma along with mallory-weiss syndrome:A case report显示文摘BACKGROUND Esophageal submucosal hematoma is a rare condition.Although the exact etiology remains uncertain,vessel fragility with external factors is believed to have led to submucosal bleeding and hematoma formation;the vessel was ruptured by a sudden increase in pressure due to nausea,and the hematoma was enlarged by antiplatelet or anticoagulant therapy.Serious conditions are rare,with a better prognosis.We present the first known case of submucosal esophageal hematoma-subsequent hemorrhagic shock due to Mallory-Weiss syndrome.CASE SUMMARY A 73-year-old female underwent endovascular treatment for an unruptured cerebral aneurysm.The patient received aspirin and clopidogrel before surgery and heparin during surgery,and was well during the surgery.Several hours after returning to the ICU,she complained of chest discomfort,vomited 500 m L of fresh blood,and entered hemorrhagic shock.Esophageal submucosal hematoma with Mallory-Weiss syndrome was diagnosed through an endoscopic examination and computed tomography.In addition to a massive fluid and erythrocyte transfusion,we performed a temporary compression for hemostasis with a Sengstaken-Blakemore(S-B)tube.Afterwards,she became hemodynamically stable.On postoperative day 1,we performed an upper gastrointestinal endoscopy and confirmed no expansion of the hematoma nor any recurring bleeding;therefore,we removed the S-B tube and clipped the gastric mucosal laceration at the esophagogastric junction.We started oral intake on postoperative day 10.The patient made steady progress,and was discharged on postoperative day 33.CONCLUSION We present the first known case of submucosal esophageal hematoma subsequent hemorrhagic shock due to Mallory-Weiss syndrome. | Jiro Oba Daisuke Usuda Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Hayabusa Takano Shintaro Shimozawa Yuta Hotchi Kenki Usami Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita | 2022 | World Journal of Clinical Cases2022，10，27： | 3 |
| 4 | Ulcerative colitis patients in clinical remission demonstrate correlations between fecal immunochemical test results, mucosal healing, and risk of relapse显示文摘AIM: To assess the risk of relapse in ulcerative colitis(UC) patients in clinical remission using mucosal status and fecal immunochemical test(FIT) results. METHODS: The clinical outcomes of 194 UC patients in clinical remission who underwent colonoscopy were based on evaluations of Mayo endoscopic subscores(MESs) and FIT results.RESULTS: Patients with an MES of 0(n = 94, 48%) showed a ten-fold lower risk of relapse than those with an MES of 1-3(n = 100, 52%)(HR = 0.10, 95%CI: 0.05-0.19). A negative FIT result(fecal hemoglobin concentrations ≤ 100 ng/m L) was predictive of patients with an MES of 0, with a sensitivity of 0.94 and a specific of 0.76. Moreover, patients with a negative FIT score had a six-fold lower risk of clinical relapse than those with a positive score(HR = 0.17, 95%CI: 0.10-0.28). Inclusion of the distinguishing parameter, sustaining clinical remission > 12 mo, resulted in an even stronger correlation between negative FIT results and an MES of 0 with respect to the risk of clinical relapse(HR = 0.11, 95%CI: 0.04-0.23).CONCLUSION: Negative FIT results one year or more after remission induction correlate with complete mucosal healing(MES 0) and better prognosis. Performing FIT one year after remission induction may be useful for evaluating relapse risk. | Asuka Nakarai Jun Kato Sakiko Hiraoka Shiho Takashima Daisuke Takei Toshihiro Inokuchi Yuusaku Sugihara Masahiro Takahara Keita Harada Hiroyuki Okada | 2016 | World Journal of Gastroenterology2016，22，21： | 3 |
| 5 | A trial of simple and easy health monitoring for power poles by using ‘ipod’显示文摘At present,the regular inspection of power poles is just a visual inspection based on the inspector’s experience.Thus,overlook of the deteriorated poles can come off.In order to avoid an accident due to the overlook of the deteriorated poles,the authors propose a simple and easy health monitoring method for power poles using‘i Pod’.Since the applicability of‘i Pod’as a vibration sensor in this purpose was not clear,it was examined in the following procedure.First,the authors proposed a tool to fix the‘i Pod’to a power pole,and the performance of‘i Pod’as a vibration measurement device was compared with a conventional acceleration sensor.As a result,it was confirmed that‘i Pod’could give almost the same response with the conventional sensor in terms of the observed predominant frequency.Next,vibration measurements were conducted at power poles in a field.As a result,the observed predominant frequency corresponded to the calculated 2nd natural frequency of power poles.Although some power poles were supported by some additional wires from the ground,the measurements were successful at almost all the sites.Hence,the authors confirmed that the‘i Pod’based health monitoring is possible. | ORAI Naoki ICHII Koji ISHII Shiho | 2015 | Science China(Technological Sciences)2015，58，4： | 2 |
| 6 | Cytapheresis re-induces high-rate steroid-free remission in patients with steroid-dependent and steroid-refractory ulcerative colitis显示文摘BACKGROUND It is a crucial issue for patients with refractory ulcerative colitis(UC),including steroid-dependent and steroid-refractory patients,to achieve and maintain steroid-free remission.However,clinical studies focused on the achievement of steroid-free remission in refractory UC patients are insufficient.Cytapheresis(CAP)is a non-pharmacological extracorporeal therapy that is effective for active UC with fewer adverse effects.This study comprised UC patients treated with CAP and suggested the efficacy of CAP for refractory UC patients.AIM To clarify the efficacy of CAP in achieving steroid-free remission in refractory UC patients.METHODS We retrospectively reviewed the collected data from 55 patients with refractory UC treated with CAP.We analyzed the following points:(1)Efficacy of the first course of CAP;(2)Efficacy of the second,third,and fourth courses of CAP in patients who experienced relapses during the observation period;(3)Efficacy of CAP in colonic mucosa;and(4)Long-term efficacy of CAP.Clinical efficacy was evaluated using Lichtiger’s clinical activity index or Sutherland index(disease activity index).Mucosal healing was evaluated using Mayo endoscopic subscore.The primary and secondary endpoints were the rate of achievement of steroidfree remission and the rate of sustained steroid-free remission,respectively.Statistical analysis was performed using the paired t-test and chi-squared test.RESULTS The rates of clinical remission,steroid-free remission,and poor effectiveness after CAP were 69.1%,45.5%,and 30.9%,respectively.There were no significant differences in rate of steroid-free remission between patients with steroiddependent and steroid-refractory UC.The mean disease activity index and Lichtiger’s clinical activity index scores were significantly decreased after CAP(P<0.0001).The rates of steroid-free remission after the second,third,and fourth courses of CAP in patients who achieved steroid-free remission after the first course of CAP were 83.3%,83.3%,and 60%,respectively.Mucosal healing was observed in all patients who achieved steroid-free remission after the first course of CAP.The rates of sustained steroid-free remission were 68.0%,60.0%,and 56.0%at 12,24,and 36 mo after the CAP.Nine patients(36%)had maintained steroid-free remission throughout the observation period.CONCLUSION Our results suggest that CAP effectively induces and maintains steroid-free remission in refractory UC and re-induces steroid-free remission in patients achieving steroid-free remission after the first course of CAP. | Masahiro Iizuka Takeshi Etou Yosuke Shimodaira Takashi Hatakeyama Shiho Sagara | 2021 | World Journal of Gastroenterology2021，27，12： | 2 |
| 7 | Acute respiratory distress syndrome associated with severe ulcerative colitis显示文摘Various extraintestinal manifestations including pulmonary abnormalities have been reported in patients with ulcerative colitis. Acute respiratory distress syndrome (ARDS) is a serious and fatal pulmonary manifestation. We have experienced a 67-year-old male patient with ARDS associated with a severe type of ulcerative colitis (UC). Severe dyspnea symptoms occurred during the treatment of UC in a previous hospital and the patient was transferred to our hospital on June 27, 2007. Both blood and sputa cultures for bacteria and fungi were negative. Cytomega-lovirus antigenemia was also not detected. From the clinical and radiological [Chest X-ray, computed tomography (CT)] findings, the patient was diagnosed with ARDS on the basis of the def inition of ARDS developed by the European-American Consensus Conference on ARDS. Both colonic inflammations and ARDS symptoms of the patient were resistant to any medical treatment includingcorticosteroids and antibiotics. However, ARDS symptoms were dramatically improved after surgical colectomy. We believe that severe colonic inflammation from UC was closely associated with the onset of ARDS of the patient. Our case report suggests that a severe type of ulcerative colitis might be taken into consideration as one of the predisposing factors of ARDS. | Shiho Sagara Yasuo Horie Yumiko Anezaki Hideaki Miyazawa Masahiro Iizuka | 2010 | World Journal of Gastroenterology2010，16，19： | 2 |
| 8 | Typical gastroduodenal endoscopic findings in a Crohn's disease patient in remission stage显示文摘A 39-year-old patient with Crohn's disease (CD) was referred to our hospital for maintenance treatment of CD.He was diagnosed as having CD of the small and large intestines at 32 years old.He underwent partial resection of the ileum at 35 years old because of ileal perforation.He had received enteral nutritional supplement (1200 kcal/d) and metronidazole preparation (500 mg/d),and was in remission Crohn's disease activity index 73.We performed a routine gastroduodenal endoscopic examination,which revealed the representative endoscopic findings of gastroduodenal lesions in CD,namely,bamboo-joint-like appearance of the gastric body and cardia and a notched sign in the duodenum.These findings were clearly observed by using indigo carmine dye spraying.In our patient,typical gastroduodenal findings were observed even in the remission stage,suggesting that these findings would contribute to the early diagnosis of CD not only in the active stage but also during remission. | Masahiro Iizuka Taku Harada Hiro-o Yamano Takeshi Etou Shiho Sagara | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，3： | 2 |
| 9 | Heat coma as an indicator of resistance to environmental stress and its relationship to ocean dynamics in the sea skaters, Halobates (Heteroptera: Gerridae)显示文摘到温度增加的忍耐为在西方的热带太平洋在二巡航期间收集的 Halobates 个人被测试(MR-06-05-Leg 3, 12 月 21 日, 2006January 12, 2007, 0 搠浥湡吗? | Tetsuo Harada Shiho Takenaka Takero Sekimoto Mitsuru Nakajyo Takao Inoue Takamasa Ishibashi Chihiro Katagiri | 2011 | Insect Science2011，18，6： | 2 |
| 10 | Titanium compounds as coatings on polystyrene lattices and as hollow spheres显示文摘 | Shiho H Kawahashi N | 2000 | J Colloid Polym Sci2000，38，7： | 1 |
| 11 | Expression ofneurotrophin genes in the brain of senescence-accelerated mouse (SAM) during postnataldevelopment显示文摘 | Kaisho Y Miyamoto M Shiho O Onoue H Kitamura Y Nomura S | 1994 | Brain Res1994，647，1： | 1 |
| 12 | Iron compounds as coatings on polystyrene latex and as hollow spheres显示文摘 | Shiho H Kawahashi N | 2000 | J Colloid and Interface Sci2000，226，1： | 1 |
| 13 | Catechins are not major components responsible for anti-genotoxic effects of tea extracts against nitroarenes显示文摘 | Takeshi Ohe Kumiko Marutani Shiho Nakase | 2001 | Mutation Research2001，496，： | 1 |
| 14 | Investigation of the microbial community in a microbiological additive used in a manure compostiag process显示文摘 | Shiho W Hiraku S Kikuji I | 2008 | Bioresource Technology2008，99，26： | 1 |
| 15 | Immune?maximizing (IMAX) therapy for cancer: Combination of dendriticcell vaccine and intensity?modulated radiation显示文摘 | Yuta Shibamoto Masato Okamoto Masanori Kobayashi Shiho Ayakawa Hiromitsu Iwata Chikao Sugie Yoko Mitsuishi Hidenori Takahashi | 2013 | Molecular and Clinical Oncology2013，，： | 1 |
| 16 | Electron flow through geometrical discontinuity in coaxial magnetically insulated transmission lines显示文摘 | Hiraoka K Nakajima M Shiho M | | 0，，9： | 1 |
| 17 | A wide range of genetic diversity in pear genetic resources from lwate,Japan revealed by SSR and chloroplast DNA markers显示文摘 | KATAYAMA HIRONORI A SHIHO Y | 2007 | Genet Resour Crop Evol2007，54，7： | 1 |
| 18 | An improved calorimetric assay for interleukin-2 显示文摘 | Shiho O Kuroshimak | 1986 | J Immunol Methods1986，93，： | 1 |
| 19 | Preparation of micron-size polystyrene particles in supercritical carbon dioxide显示文摘 | Shiho H DeSimone J M | 1999 | J Polym Sci Part A --Polym Chem1999，37，： | 1 |
| 20 | Effects of soybean curd wastewater on the growth and hydrocarbon production of Botryococcus braunii strain BOT-22 显示文摘 | Yonezawa N Matsuura H Shiho M | 2012 | Bioresource Technology2012，109，： | 1 |
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