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| 1 | Antibiotics,gut microbiota,and irritable bowel syndrome:What are the relations?显示文摘Irritable bowel syndrome(IBS)is a functional gastrointestinal disorder in which recurrent abdominal pain is associated with defecation or a change in bowel habits(constipation,diarrhea,or both),and it is often accompanied by symptoms of abdominal bloating and distension.IBS is an important health care issue because it negatively affects the quality of life of patients and places a considerable financial burden on health care systems.Despite extensive research,the etiology and underlying pathophysiology of IBS remain incompletely understood.Proposed mechanisms involved in its pathogenesis include increased intestinal permeability,changes in the immune system,visceral hypersensitivity,impaired gut motility,and emotional disorders.Recently,accumulating evidence has highlighted the important role of the gut microbiota in the development of IBS.Microbial dysbiosis within the gut is thought to contribute to all aspects of its multifactorial pathogenesis.The last few decades have also seen an increasing interest in the impact of antibiotics on the gut microbiota.Moreover,antibiotics have been suggested to play a role in the development of IBS.Extensive research has established that antibacterial therapy induces remarkable shifts in the bacterial community composition that are quite similar to those observed in IBS.This suggestion is further supported by data from cohort and case-control studies,indicating that antibiotic treatment is associated with an increased risk of IBS.This paper summarizes the main findings on this issue and contributes to a deeper understanding of the link between antibiotic use and the development of IBS. | Zarina Mamieva Elena Poluektova Valery Svistushkin Vasily Sobolev Oleg Shifrin Francisco Guarner Vladimir Ivashkin | 2022 | World Journal of Gastroenterology2022，28，12： | 8 |
| 2 | Trichothecene mycotoxins trig- ger a ribotoxic stress response that activates c -Jan N -terminal kinase and p38 mitogen -activated protein kinase and induces apoptosis 显示文摘 | Shifrin V I Anderson P | 1999 | Journal of Biological Chemistry1999，274，13： | 1 |
| 3 | Transluminal dilatation of the subclavian artery显示文摘 | Roy L. Gordon M.D. Liliana Haskell Menahem Hirsch Edward Shifrin Eran Weinman Henry Romanoff | 1985 | Cardiovascular and Interventional Radiology1985，，1： | 1 |
| 4 | Growth factor-inducible alternative splicing of nontransmembrane phosphotyrosine phosphatase PTP-1B pre-mRNA显示文摘 | SHIFRIN V I NEEL B G | 1993 | J Biol Chem1993，268，25： | 1 |
| 5 | Uhrafast contrast-enhanced three dimensiotud MR angiography : stare of the art 显示文摘 | Alley MT Shifrin RY Pelc NJ | 1998 | Radiographics1998，18，： | 1 |
| 6 | New insights into the development of popliteal cysts显示文摘 | Labropoulos N Shifrin DA Paxinos O | 2004 | Br J Surg2004，10，： | 1 |
| 7 | Phytoplankton lipids:interspe- cifie differences and effects of nitrate, silicate and light- dark cycles显示文摘 | Shifrin N S Chisholm S W | 1981 | JPhyeol1981，17，： | 1 |
| 8 | Effect of epidural bupivacaine block on midazolam hypnotic requirements显示文摘 | Tverskoy m shifrin V Finger J | 1996 | Rey Anesth1996，21，： | 1 |
| 9 | A highly sensitive silver stain for detecting proteins and peptides in polyacrylamide gels显示文摘 | Merrill C R Shifrin S | 1979 | Analytical Biochemistry1979，98，： | 1 |
| 10 | Canine osteosareoma karyotypes from an original tumor, its metastasis, and tumor cells in tissue culture显示文摘 | Taylor N Shifrine M Wolf HG | 1975 | Transplant Proc1975，7，4： | 1 |
| 11 | Benzoquinonoid ansa- mycins possess selective tumoricidal activity unrelated to src ki- nase inhibition 显示文摘 | Whitesell L Shifrin S D Schwab G | 1992 | Cancer Res1992，52，： | 1 |
| 12 | Name that tune:a pilot study in finding a melody from a sung query显示文摘 | Pardo B Shifrin Jonah Birmingham William | 2004 | Journal of the American Society for Information Science and Technology2004，55，4： | 1 |
| 13 | Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition 显示文摘 | WHITESELLL SHIFRIN S D SCHWAB G | 1992 | Cancer Res1992，52，7： | 1 |
| 14 | Virtual bronchoscopy显示文摘 | Vining DL Shifrin BY Haponik EF | 1994 | Radiology1994，193，2： | 1 |
| 15 | Arthroscopy of a dislocated hip re-placement:a case report 显示文摘 | Shifrin LZ Reis ND | 1980 | Clin Orthop Relat Res1980，，146： | 1 |
| 16 | Virtual Bronchoscopy显示文摘 | Vining DJ Shifrin RY Haponik EF | 1994 | Radiology1994，193，： | 1 |
| 17 | Optimal dosing as a necessary condition for the efficacy of hyperbaric oxygen therapy inacute ischemic stroke: a critical review显示文摘 | Rogatsky GG Shifrin EG Mayevsky A | 2003 | Neurol Res2003，25，1： | 1 |
| 18 | Antiepileptic drugs in the treatment of neuropathic pain显示文摘 | Eisenberg E River Y Shifrin A | 2007 | Drugs2007，67，9： | 1 |
| 19 | The nontransmembrane tyrosine phosphatase PTP-I B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence显示文摘 | Frangioni J V Beahm P H Shifrin V | 1992 | Cell1992，68，3： | 1 |
| 20 | Virtual colonoscopy显示文摘 | Vining DJ Shifrin RY Haponik EF | 1994 | Radiology1994，193，： | 1 |
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