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	题名	作者	年代	出处	被引量
1	Personalized chemotherapy in clear cell adenocarcinoma of the urethra:A case report显示文摘BACKGROUND Clear cell adenocarcinoma of the urethra is a rare type of aggressive cancer with a poor prognosis.Clear cell carcinoma of the urethra represents less than 0.02%of all malignancies in women.Adenocarcinomas account for 10%of female urethral carcinomas,of which 40%are the clear cell variant.Determining the presence or absence of certain mutations through genetic testing may predict whether a patient with cancer may benefit from a particular chemotherapy regimen.CASE SUMMARY A 40-year-old woman presented with a 3-year history of slow urinary flow and a 3-mo history of urinary urgency and frequency as well as gross hematuria.An abdominal and pelvic computed tomography scan demonstrated enlarged lymph nodes in the abdomen and pelvis.A biopsy of a left inguinal lymph node microscopically confirmed a metastatic adenocarcinoma of the urethra.Specialized genetic testing determined personalized chemotherapy.She was treated successfully with a non-platinum-based chemotherapy consisting of paclitaxel and bevacizumab.Following 3 cycles of paclitaxel and bevacizumab,she attained significant clinical improvement,and response by FDG-Positron emission tomography(PET)imaging showed a definite improvement in size and metabolic activity.She achieved complete response after 6 cycles of therapy by PET scan.The patient concluded 11 cycles of paclitaxel and bevacizumab,and a subsequent PET scan confirmed progression of metastatic disease.The patient was then treated with two cycles of doxorubicin after which a PET scan revealed a mixed response to the treatment.CONCLUSION We report the first case of a patient with metastatic clear cell adenocarcinoma of the urethra who underwent personalized chemotherapy after testing for cancer gene alterations.Our unique case represents the safe and effective use of nonplatinum-based chemotherapy in clear cell adenocarcinoma of the urethra.	Lisa B E Shields Arash Rezazadeh Kalebasty	2020	World Journal of Clinical Oncology2020，11，4：	3
2	Intensity-modulated radiotherapy (IMRT) and concurrent capecitabine for pancreatic cancer显示文摘	Ben-Josef E Shields AF Vaishampayan U	2004	Int J Radiat Oncol Biol Phys2004，59，：	1
3	Shear stress - strain - time behaviour of clays显示文摘	Mesri G Rebres - Cordero E Shields D R	1981	Géotechnique1981，，04：	1
4	Workflows ande-Science: An Overview of Workflow System Featuresand Capabilities显示文摘	Deelman E Gannon G Shields M	2009	Future Generation ComputerSystems2009，25，5：	1
5	Near room-temperature magnetoealoria properties of Gd-Ga alloys 显示文摘	Tanjore V Jayaraman Laura Boone Jeffrry E Shield	2014	J Magn Magn Mater2014，363，：	1
6	CD163 expression confers susceptibility to porcine reproductive and respiratory syndrome viruses显示文摘	Calvert J G Slade D E Shields S L	2007	J Virol2007，81，14：	1
7	Towards the Characterization of Large Retail Stores 显示文摘	Shields T J Boyce K E Silcock G W H	1999	Fire and Materials1999，23，：	1
8	Absolute Isotopic Abundance Ratio and the Atomic Weight of Chlorine 显示文摘	Shields W R Murphy T J Garner E L	1962	Journal of the A- merican Chemical Society1962，84，：	1
9	Periphyton responses tonutrient and atrazine mixtures introduced through agricultural runoff显示文摘	Murdock J N Shields Jr F D Lizotte Jr R E	2013	Ecotoxicology2013，22，2：	1
10	Home safety and low-income urban housing quality显示文摘	Gielen AC Shields W McDonald E	2012	Pediatrics2012，130，6：	1
11	Mag- netocaloric effect and refrigerant capacity in melt-spun Gd- Mn alloy显示文摘	Tanjore V Jayaraman Laura Boone Jeffrry E Shield	2013	J Magn Magn Mater2013，345，：	1
12	Residence Time Distributions Of Shallow Basins显示文摘	Thackston E L F Shields D Schroeder P R	1987	Journal of Environmental Engineering1987，113，6：	1
13	Iden- tification and characterization of a cellular gene essential for PRRS virus infection, 2005 international PRRS symposium 显示文摘	WELCH S K W SLADE D E SHIELDS S L	2005	St Louis Missoud2005，2，：	1
14	The effect of noiseon children at school: a review显示文摘	Bridget M Shield Julie E Dockrell	2003	Building Acoustics2003，10，2：	1
15	Urinary heparan sulphate proteoglyean excretion is abnormal in insulin dependent diabetes显示文摘	SHIELD J P CARRADUS M STONE J E	1995	Ann Clin Biochem1995，32，6：	1
16	Natural variations in the abundance ratio and the atomic weight of copper显示文摘	Shield W R Goldich S S Garner E L	1965	J Geophys Res1965，70，：	1
17	Interactive inverse design opti- mization of fuselage shape for low-boom supersonic concepts显示文摘	Li W Shields E Le D	2008	Journal of Aircraft2008，45，4：	1
18	A proposed classification for heritable human dentine defects with a description of a new entity显示文摘	Shields E D Bixler D el-Kafrawy A M	1973	Arch Oral Biol1973，18，4：	1
19	Mycotic pneumonia in mariculture reared green turtles显示文摘	Jacobson E R Gaskin J M Shields R P	1979	Am Vet Med Assoc1979，175，：	1
20	External and internal noise surveys of London primary schools显示文摘	Bridget Shield and Julie E Dockrell	2004	J Acoust Soc Am2004，115，2：	1

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