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| 1 | Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury. | Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 12 |
| 2 | 吸烟肺癌患者口腔黏膜细胞全线粒体DNA获得性突变分析 吸烟/口腔黏膜获得性突变与康复预防显示文摘目的了解肺癌患者口腔黏膜mtDNA获得性突变情况,探讨肺癌外细胞的线粒体基因突变与肺癌的关系和作为对肺癌预测的生物学指标的可能性。方法利用时相温度梯度凝胶电泳法对12例肺癌患者(吸烟者10例,非吸烟者2例)口腔黏膜细胞及匹配的血液细胞线粒体DNA进行突变筛选,然后进行测序分析。结果在大部分吸烟患者中(8/9),发现口腔黏膜具有两个以上的获得性突变,而在两个非吸烟的患者仅发现1个突变。在11例(11/12,92%)患者中共发现有26个获得性突变,15个突变发生在高变的D环区(58%),11个在mRNA区(42%)。除303~309位点具有长度不稳定外,未见其他微卫星不稳定和5kb的大范围缺失突变。结论吸烟的肺癌患者口腔黏膜细胞线粒体DNA具有高发生频率的获得性突变。 | 刘玲玲 谭端军 赵玉生 施伟伟 Peter Shields Lee-Jun C Wong | 2003 | 中国临床康复2003，7，15： | 10 |
| 3 | Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf -independent pathways显示文摘 | Shields J M Rogers Graham K Der C J | 2002 | J Biol Chem2002，277，12： | 1 |
| 4 | Calibration of mitochondrial DNA evolution in geese显示文摘 | Wilson A C | 1987 | J Mol Evo1987，24，： | 1 |
| 5 | Surgent-student e-Learning for reality:the application of interactive visual images to problembased learning in undergraduate surgery显示文摘 | Corrigan M Reardon M Shields C | 2008 | Joumal of Surgical Exlucation2008，65，2： | 1 |
| 6 | In vivo response of polylactic acid-alginate scaffolds and bone marrow-derived cells for cartilage tissue engineering显示文摘 | Wayne J S McDowell C L Shields K J | 2005 | Tissue Eng2005，11，56： | 1 |
| 7 | Development length of glassfiber reinforced polymer bars in concrete 显示文摘 | Wambeke B W Shield C K | 2006 | ACIStructural Journal2006，103，1： | 1 |
| 8 | Trace element chemostratig-raphy of two Ediacaran-Cambrian successions in South China:Implications for organosedimentary metal enrichment and si-licification in the early Cambrian显示文摘 | Guo Q Shields G A Liu C | 2007 | Palaeogeography Palaeo-climatology Palaeoecology2007，254，254： | 1 |
| 9 | Comparisons among VOCs measured in three types of US commercial buildings with different occupant densities显示文摘 | Shields H C Fleischer D M Weschler C J | 1996 | Indoor Air1996，6，1： | 1 |
| 10 | Lung Injury in Acute Pancreatitis: Mechanisms, Prevention, and Therapy显示文摘 | Shields C J Winter D C Redmond H P | 2002 | Curr Opin Crit Care2002，8，2： | 1 |
| 11 | Partial lamellar sclerouvectomy for ciliary body and choroidal tumors显示文摘 | SHIELDS J A SHIELDS C L SHAH P | 1991 | Ophthalmology1991，98，： | 1 |
| 12 | Surgent-student e- Learn-ing for reality: the application of interactive visual images to problem -based learning in undergraduate surgery 显示文摘 | Corrigan M Reardon M Shields C | 2008 | J of Sur Educ2008，65，2： | 1 |
| 13 | Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via Interstitial flow and autocrine CCR7 signaling显示文摘 | Shields JD Fleury ME Yong C | 2007 | Cancer Cell2007，11，6： | 1 |
| 14 | Dopamine D4 receptors and the risk of cigarette smoking in African-Americans and Caucasians显示文摘 | Shields PG Lerman C Audrain J | 1998 | Cancer Epidemiol Biomarkers Prev1998，7，6： | 1 |
| 15 | Control of degradation with vegetation and structure显示文摘 | Shields F D J R Bowie A J Cooper C M | 1995 | Water Resources Bulletin1995，31，3： | 1 |
| 16 | Assignment in the integration of urban traffic control and dynamic route guidance,in urban traffic networks dynamic flow modeling and control显示文摘 | Bell M G H Shield C M Anderson J M | 1995 | Springer-Verlag1995，，： | 1 |
| 17 | Triazole Cross-Risistance among Candida spp.:case report,occurrence among bloodstream isolates,and implications for antifungal therapy显示文摘 | Magill SS Shields C Sears CL | | 0，，： | 1 |
| 18 | Proliferative radiation retinopathy after plaque radiotherapy for uveal melanoma显示文摘 | Bianciotto C Shields CL Pirondini C | | 0，，05： | 1 |
| 19 | Awake thyroidectomy under local anesthesia and dexmedetomidine infusion显示文摘 | PLUNKETT AR SHIELDS C STOJADINOVIC A et ol | 2009 | Mil Med2009，174，1： | 1 |
| 20 | Classification and management of Coats disease: the 2000 Proctor Lecture 显示文摘 | Shields J A Shields C L Honavar S G | 2001 | Am J Ophthalmol2001，131，5： | 1 |
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