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3篇 您的检索式：作者名="Sheyu Lin"

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		题名	作者	年代	出处	被引量
	1	Study on the migration of nerve stem cell in vitro Induced by glioma cells显示文摘Objective: Previous studies have shown that glioma cells induced the migration of nerve stem cells (NSCs) in vivo. This study was exploring whether this situation could happen in vitro. Methods: Supernatant from C6 glioma cell lines or astrocytes cultured in serum-free medium growing in logarithmic phase were separately placed in lower chambers and NSCs were placed in the upper chambers of Trans-well culture system. After 36 h co-incubation, these NSCs spheres occurred on the middle membrane were counted. Results: Results demonstrated that the supernatant from C6 glioma cell culture, not from the astrocytes, enhanced the migration of NSCs (P<0.01). Conclusion: Some components in C6 glioma cell culture can attract the migration of NSCs.	Yilu Gao Shuzi Gao Yi Fen Sheyu Lin Mei Liu	2005	Journal of Nanjing Medical University2005，19，6：	2
	2	Association of Interleukin 6 gene polymorphisms with genetic susceptibilities to spastic tetraplegia in males: A case-control study显示文摘	Mingjie Chen Tongchuan Li Sheyu Lin Dan Bi Dengna Zhu Qing Shang Caiyun Ma Honglian Wang Lei Wang Yiting Zhang Lin He Changlian Zhu Qinghe Xing	2013	Cytokine2013，，：	1
	3	Supramolecular assembly of Cp1-11 peptide and insulin for rapid-acting formulation显示文摘In order to improve the life quality of diabetic patients,it is very important to develop rapid-acting insulin formulations that can mimic the physiological meal-time secretion profile of insulin in healthy people.Although several insulin analogues have been designed to provide postprandial glycemic control,still there are some serious disadvantages.A supramolecular strategy is presented here to inhibit insulin aggregation and improve its bioactivity by using Cp1-11 peptide.As a fragment of C-peptide in proinsulin,Cp1-11 peptide was found to influence insulin oligomerization by supramolecular interactions.This work demonstrates that the Cp1-11 peptide can interact with oligomeric insulin and facilitate its disaggregation into the physiologically active monomeric form.Computer simulation indicates that Cp1-11 can insert into the space between the C-terminal tail and the N-terminal helix of the B-chain of insulin,causing dissociation of the insulin dimer.The supramolecular assembly of Cp1-11 and insulin can improve the bioavailability and therapeutic effect of insulin on the control of in vivo blood glucose levels.These results suggest that Cp1-11 peptide can modulate the intermolecular interaction of aggregated insulin and prevent the transition from monomeric to multimeric states,and shows great potential for the development of an effective rapid-acting strategy to treat diabetes.	Weigang Wang Sheyu Li Zhouxiang Zhao Anna Zhou Yanpeng Liu Yantao Chen Mingchang Lin Guosong Chen Chunmei Ding Jianshu Li	2017	Journal of Bioresources and Bioproducts2017，2，3：	0

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