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| 1 | Advances in aggregatable nanoparticles for tumor-targeted drug delivery显示文摘Recent days,aggregatable nanoparticles,which can specifically respond to certain stimulus,have shown great potential in tumor-targeted drug delivery with prolonged retention and deeper penetration.In this review,we summarize recent advances in design of aggregatable nanoparticles by different stimuli.Internal(pH and enzyme)and external(light,temperature and ROS)stimuli are introduced for a comprehensive description.Moreover,the aggregated nanoparticles usually exhibit photothermal,photoacoustic,PET and enhanced MRI contrast,which is also described.In the end,we discuss about the potential applications and challenges for the future clinical translation. | Wenqi Yu Maxim Shevtsov Xianchun Chen Huile Gao | 2020 | Chinese Chemical Letters2020，31，6： | 6 |
| 2 | Expression of Mitochondrial Gene Fragments within the Tapetum Induce Male Sterility by Limiting the Biogenesis of the Respiratory Machinery in Transgenic Tobacco显示文摘Plant mitochondrial genomes (mtDNAs) are large and undergo frequent recombination events. A common phenotype that emerges as a consequence of altered mtDNA structure is cytoplasmic-male sterility (CMS). The molecular basis for CMS remains unclear, but it seems logical that altered respiration activities would result in reduced pollen production. Analysis of tobacco (Nicotiana tabacum) mtDNAs indicated that CMS-associated loci often contain fragments of known organellar genes. These may assemble with organellar complexes and thereby interfere with normal respiratory functions. Here, we analyzed whether the expression of truncated fragments of mitochondrial genes (i.e. atp4, cox1 and rps3) may induce male sterility by limiting the biogenesis of the respiratory machinery. cDNA fragments corresponding to atp4f, cox1f and rps3f were cloned in-frame to a mitochondrial localization signal and a C-termini HA-tag under a tapetum-specific promoter and introduced to tobacco plants by Agrobacterium-mediated transformation. The constructs were then analyzed for their effect on mitochondrial activity and pollen fertility. Atp4f , Cox1f and Rps3f plants demonstrated male sterility phenotypes, which were tightly correlated with the expression of the recombinant fragments in the floral meristem. Fractionation of native organellar extracts showed that the recombinant ATP4f-HA, COX1f-HA and RPS3f-HA proteins are found in large membrane-associated particles. Analysis of the respiratory activities and protein profiles indicated that organellar complex I was altered in Atp4f, Cox1f and Rps3f plants. | Felix Shaya Svetlana Gaiduk Ido Keren Sofia Shevtsov Hanita Zemah Eduard Belausov Dalia Evenor Moshe Reuveni Oren Ostersetzer-Biran | 2012 | Journal of Integrative Plant Biology2012，54，2： | 4 |
| 3 | The effect d tunneling on the pressare in the tibial cavity in arterial insufficiency in the extremity 显示文摘 | Shevtsov VI Bunov VS Gorttievskikh NI | 1999 | Vestn Khir Im I I Grek1999，158，6： | 1 |
| 4 | Optimal design of wheel profile for railway vehicles 显示文摘 | Shevtsov I Y Markine V L Esveld C | 2005 | Wear2005，258，78： | 1 |
| 5 | Experience in the Prevention of Frost Heave of Pile Foundations of Transmission Towers under Northern Conditions显示文摘 | A. L. Lyazgin V. S. Lyashenko S. V. Ostroborodov V. G. Ol’shanskii R. M. Bayasan K. P. Shevtsov G. P. Pustovoit | 2004 | Power Technology and Engineering2004，，2： | 1 |
| 6 | Application of external fixation for management of hand syndactyly显示文摘 | Shevtsov VI Danilkin MY | 2008 | Int Orthop2008，32，4： | 1 |
| 7 | Design of railway wheel profile taking into account rolling contact fatigue and wear 显示文摘 | Shevtsov I Y Markine V L Esveld C | 2008 | Wear2008，265，1112： | 1 |
| 8 | Design of Railway Wheel Profile Taking into Account Rolling Con- tact Fatigue and Wear显示文摘 | SHEVTSOV I Y MARKINE V L ESVELD C | 2008 | Wear2008，265，910： | 1 |
| 9 | The use of coordinate-measurement machines to optimize the technology of automatic shaping of optical surfaces 显示文摘 | V N Chekal Y I Chudakov S E Shevtsov | 2008 | J Opt Tech2008，25，11： | 1 |
| 10 | An Inverse Shape Design Method for Railway Wheel Profiles 显示文摘 | MARKINE V L SHEVTSOV I Y ESVELD C | 2007 | Structural and Multidisciplinary Optimization2007，33，3： | 1 |
| 11 | Shape Optimization of a Railway Wheel Profile显示文摘 | ESVELD C MARKINE V L SHEVTSOV I Y | 2006 | European Rail- way Rev2006，12，2： | 1 |
| 12 | Highly parallel fast KD-tree construction for interactive ray tracing of dynamic scenes显示文摘 | Shevtsov M Soupikov A Kapustin A | | 0，，03： | 1 |
| 13 | Optimal design of wheel profile for railway vehicles显示文摘 | SHEVTSOV I Y MARKINE V L ESVELD C | 2005 | Wear2005，258，78： | 1 |
| 14 | The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy显示文摘 | Chen X Shevtsov SP Hsich E | 2006 | Mol Cell Biol2006，，12： | 1 |
| 15 | Design of railway wheel profile taking into account rolling contact fatigue andwear显示文摘 | SHEVTSOV I Y MARKINE V L ESVELD C | 2008 | Wear2008，265，910： | 1 |
| 16 | Research of forage microstructure as an object of extrusion technology显示文摘 | Shevtsov AA Vasilenko VN Ojerelieva ON | | 0，，02： | 1 |
| 17 | Neurothera peutic activity of the recombinant heat shock protein HspT0 in a model of focal cerebral ischemia in rats 显示文摘 | Shevtsov MA Nikolaev BP Yakovleva LY | 2014 | Drug Des Devel T her2014，8，63： | 1 |
| 18 | Design of railway wheel profile taking into account of rolling contact fatigue and wear显示文摘 | SHEVTSOV I Y MARKINE V L ESVELD C | 2008 | Wear2008，265，910： | 1 |
| 19 | Some new tendencies in the development of electrical resistance furnace and production processes for heat and chemical heat treatment of metal abroad显示文摘 | SHEVTSOV M A | 1987 | Metal Science and Heat Treatment1987，29，56： | 1 |
| 20 | Optimal Design of Wheel Profile for Railway Vehicles显示文摘 | I Y Shevtsov V L Markine C Esveld | 2005 | Wear2005，258，78： | 1 |
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