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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Yield, Sensory Properties, and Nutritive Qualities of Quarg Produeed from Laetose-Hydrolyzed and High Heated Milk显示文摘 | Sheth H Jelen P Ozimek L | 1988 | Journal of Dairy Science1988，71，11： | 1 |
| 3 | Biomass gasification models for downdraft gasifier:A state-of-the-art review显示文摘 | PATRA T K SHETH P N | 2015 | Renewable and Sustainable Energy Reviews2015，50，： | 1 |
| 4 | Federated database system for managing distributed, heterogeneous, and autonomous database 显示文摘 | SHETH A P LARSON J A | 1990 | AGM Computing Suweys1990，22，3： | 1 |
| 5 | Quality of service for workflows and Web service processes显示文摘 | CARDOSO J SHETH A P MILLER J A | 2004 | Web Semantics2004，1，3： | 1 |
| 6 | Liquid crystalline, rheological and thermal properties of konjac glucomannan 显示文摘 | Dave V Sheth M McCarthy S P | 1998 | Polymer1998，39，5： | 1 |
| 7 | Federated database systems for managing distributed, heterogeneous, and autonomous databases显示文摘 | Sheth A P Larson J A | 1990 | ACM Computing Surveys1990，22，3： | 1 |
| 8 | Solid state structure- property behavior of semicrystallinepoly(ether-block-amide) PEBAw ther- moplastic elastomers显示文摘 | Jignesh P Sheth Jiannong Xu Garth L Wilkes | 2003 | Polymer2003，44，： | 1 |
| 9 | Federated database systems for managing distributed, heterogeneous, and autonomous database 显示文摘 | Sheth A P Larson J A | 1990 | ACM Computing Surveys1990，922，3： | 1 |
| 10 | Viscosity of Molten Metals and ItsTemperature Dependence 显示文摘 | Chhabra R P Sheth D K | 1990 | Z Metallkde1990，81，4： | 1 |
| 11 | An overview of workflow management: from process modeling to workflow automation infrastructure 显示文摘 | Georgakopoulos D Hornick M F Sheth A P | 1995 | Distdbuted and Parallel Databases1995，3，2： | 1 |
| 12 | Intravitreal ranibizumab versus bevacizumab for treatment of myopic choroidal neovascularization 显示文摘 | Iacono P Parodi MB Papayannis A Kontadakis S Sheth S Cas- cavilla ML | 2012 | Reti- na2012，32，8： | 1 |
| 13 | Protein phosphatases 2A and 1 inter- act with oeeludin and negatively regulate the assembly of tight junctions in the CACO-2 cell monolayer 显示文摘 | Seth A Sheth P Elias BC | 2007 | J Biol Chem2007，282，11： | 1 |
| 14 | Ankle disk t raining influences reaction times of selected muscles in a simulated ankle sprain显示文摘 | Sheth P Yu B Laskowski ER | 1997 | Am J Sports Med1997，25，： | 1 |
| 15 | Novel treat- ment of chronic severe hand dermatitis with bexarotene gel显示文摘 | Hanifin JM Stevens V Sheth P | 2004 | Br J Dermatol2004，150，3： | 1 |
| 16 | Role of Chain Symmetry and Hydrogen Bonding in Segmen- ted Copolymers with Monodisperse Hard Segments 显示文摘 | SHETH J P KLINEDINST D B WILKES G L | 2005 | Polymer2005，46，18： | 1 |
| 17 | Development of a single ELISA fordetection of sulphonamides显示文摘 | Sheth H B Sporns P | 1991 | Journal of Agriculture and Food Chemistry1991，39，： | 1 |
| 18 | Catalytic gasification of coal using eutectic salts: Identification of eutectics显示文摘 | YEBOAH Y D XU Y SHETH A GODAVAITY A AGRAWAI P K | 2003 | Carbon2003，41，2： | 1 |
| 19 | Experimental studies on producer gas generation from wood waste in a downdraft biomass gasifier显示文摘 | Sheth P N Babu B V | 2009 | Bioresource Technology2009，100，12： | 1 |
| 20 | Activation of protease activated receptor2 by exogenous agonist exacerbates early radiation injury in rat intestine显示文摘 | Vidwan P Pathak A Sheth S | | 0，，04： | 1 |
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