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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Giant cell tumor of the distal radius 显示文摘 | Sheth DS Healey JH Sobel M | 1995 | J Hand Surg Am1995，20，3： | 1 |
| 3 | Giant cell tumor of the distalradius显示文摘 | Sheth DS Healey JH Sobel M | 1995 | J Hand Surg Am1995，20，3： | 1 |
| 4 | Conservative surgery for giant cell tumors of the sacrum:The role of cryosurgery as a supplement to curettage and partial excision 显示文摘 | Marcove RC Sheth DS Brien EW | 1994 | Cancer1994，74，4： | 1 |
| 5 | Total knee arthroplasty in hemophilic arthropathy显示文摘 | Sheth DS Oldfield D Ambrose C | 2004 | J Arthoplasty2004，19，1： | 1 |
| 6 | Giant cell tumor of the radius 显示文摘 | Sheth DS Healy JH Sobel M | 1995 | J Hand Surg1995，20，3： | 1 |
| 7 | Conventional and dedifferentiated parosteal osteosarcoma显示文摘 | Sheth DS Yasko AW Raymond AK | 1996 | Cancer1996，78，10： | 1 |
| 8 | Antioxidant neuroprotection against ethanol - induced apoptosis in HN2 - 5 cells 显示文摘 | Sheth DS Tajuddin NF Druse MJ | 2009 | Brain Res2009，1285，： | 1 |
| 9 | Antioxidant neuroprotection a- gainst ethanol-induced apoptosis in HN2-5 cells 显示文摘 | Sheth DS Tajuddin NF Druse MJ | 2009 | Brain Res2009，1285，： | 1 |
| 10 | The treatment of aneurysmal bone eyst显示文摘 | Mareove RC Sheth DS Takemoto S | 1995 | Clin Orthop1995，311，： | 1 |
| 11 | Antioxidant neuroprotection against ethanol-induced apoptosis in HN2-5 cells显示文摘 | Sheth DS Tajuddin NF Druse MJ | 2009 | Brain Res2009，1285，3： | 1 |
| 12 | Giant cell tumor of the distal radius显示文摘 | Sheth DS Healey JH Sobel M | 1995 | J Hand Surg Am1995，20，3： | 1 |
| 13 | Conservative surgery for giant-cell tumors of the sacrum the role of croysurgery as a supplement to curettage and partial excision显示文摘 | Marcove RC Sheth DS Brien EW | | 0，，04： | 1 |
| 14 | Antioxidant neuroprotection against ethanol-induced apoptosis in HN2-5 cells显示文摘 | Sheth DS Tajuddin NF Druse MJ | 2009 | Brain Res2009，1285，： | 1 |
| 15 | Functional andoncological outcome of acetabular reconstruction for the treatmentof metastatic disease 显示文摘 | Marco RA Sheth DS Boland PJ | 2000 | J Bone Joint Surg Am2000，82，： | 1 |
| 16 | Total knee arthroplasty in hemophilic arthropathy 显示文摘 | Sheth DS Oldfield D Ambrose C | 2004 | J Arthroplasty2004，19，1： | 1 |
| 17 | Antioxidant neuroprotection against ethanol-induced apoptosis in HN2-5 cells显示文摘 | Sheth DS Tajuddin NF Druse MJ | 2009 | Brain Res2009，1285，： | 1 |
| 18 | Antioxidant neuroprotection against ethanol-induced apoptosis in HN2-5 ceils 显示文摘 | Sheth DS Tajuddin NF Druse MJ | 2009 | Brain Res2009，1285，： | 1 |
| 19 | Conservative surgery for giant cell tumors of the sacrum:the role of cryosurgery as a supplement to curettage and partial excision显示文摘 | Marcove RC Sheth DS Brien EW | 1994 | Cancer1994，74，4： | 1 |
| 20 | Giant cell tumor of the distal radius 显示文摘 | Sheth DS Healey JH Sobel M | 1995 | J Hand Surg1995，20，3： | 1 |
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