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| 1 | Alcohol-induced protein hyperacetylation: Mechanisms and consequences显示文摘Although the clinical manifestations of alcoholic liver disease are well-described, little is known about the molecular basis of liver injury. Recent studies have indicated that ethanol exposure induces global protein hyperacetylation. This reversible, posttranslational modification on the ε-amino groups of lysine residues has been shown to modulate multiple, diverse cellular processes ranging from transcriptional activation to microtubule stability. Thus, alcoholinduced protein hyperacetylation likely leads to major physiological consequences that contribute to alcohol-induced hepatotoxicity. Lysine acetylation is controlled by the activities of two opposing enzymes, histone acetyltransferases and histone deacetylases. Currently, efforts are aimed at determining which enzymes are responsible for the increased acetylation of specifi c substrates. However, the greater challenge will be to determine the physiological ramifications of protein hyperacetylation and how they might contribute to the progression of liver disease. In this review, we will fi rst list and discuss the proteins known to be hyperacetylated in the presence of ethanol. We will then describe what is known about the mechanisms leading to increased protein acetylation and how hyperacetylation may perturb hepatic function. | Blythe D Shepard Pamela L Tuma | 2009 | World Journal of Gastroenterology2009，15，10： | 3 |
| 2 | Alcohol-induced alterations of the hepatocyte cytoskeleton显示文摘The hepatocyte cytoskeleton consists of three fi lamentous networks: microtubules, actin microfi laments and keratin intermediate filaments. Because of the abundance of the proteins that comprise each system and the central role each network plays in a variety of cellular processes, the three fi lament systems have been the focus of a host of studies aimed at understanding the progression of alcohol-induced liver injury. In this review, we will briefly discuss the hepatic organization of each cytoskeletal network and highlight some components of each system. We will also describe what is known about ethanol-induced changes in the dynamics and distributions of each cytoskeletal system and discuss what is known about changes in protein expression levels and post-translational modifi cations. Finally, we will describe the possible consequences of these cytoskeletal alterations on hepatocyte function and how they might contribute to the progression of liver disease. | Blythe D Shepard Pamela L Tuma | 2010 | World Journal of Gastroenterology2010，16，11： | 2 |
| 3 | Genome sequences and phylogenetic analysis of K88and F18positive porcine enterotoxigenic Escherichia coli显示文摘 | Shepard S M Danzeisen J L Isaacson R E | 2012 | J Bacteriol2012，194，2： | 1 |
| 4 | Global epidemiology of hepatitis C virus infection显示文摘 | Shepard CW Finelli L Alter M J | | 0，，09： | 1 |
| 5 | The Role of Assessment in a Learn- ing Culture显示文摘 | SHEPARD L A | 2000 | Educational Researcher2000，29，7： | 1 |
| 6 | An evaluation of two equations for predicting fetal weight by ultrasound 显示文摘 | SHEPARD M J RICHARDS V A BERKOWITZ R L | 1982 | Am J Obstet Gynecol1982，，142： | 1 |
| 7 | Maternal anthropometric factors and risk of primary cesarean delivery显示文摘 | Shepard M J Saftlas AF Leo - Summers L | 1998 | Am J Public Health1998，88，10： | 1 |
| 8 | The role of assessment in a learning culture显示文摘 | Shepard L | 2000 | Educational Researcher2000，29，7： | 1 |
| 9 | Global epidemiology of hepatitis C virus infection显示文摘 | Shepard CW Finelli L Alter MJ | 2005 | Lancet Infect Dis2005，5，9： | 1 |
| 10 | Evaluating test validity 显示文摘 | SHEPARD L A | 1993 | Review of Research in education1993，19，： | 1 |
| 11 | Global epidemiology of hepatitis C virus infection显示文摘 | Shepard CW Finelli L Alter MJ | 2005 | Lancet Infect Dis2005，5，9： | 1 |
| 12 | Nearshore water circulation related to bottom topography and wave refraction显示文摘 | Shepard F P Inman D L | 1950 | Transactions American Geophysical U- nion1950，31，： | 1 |
| 13 | Global epidemiology of hepatitis C virus infeetion显示文摘 | Shepard CW Finelli L Alter MJ | 2005 | Lancet Infect ion Disease2005，5，9： | 1 |
| 14 | Harmony:Static noise analysis of deep submicron digital integrated circuits显示文摘 | Shepard Kenneth L Narayanan Vinod Rose Ron | 1999 | IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems1999，18，8： | 1 |
| 15 | Global epidemiology of hepatitis C virus infection显示文摘 | Shepard CW Finelli L Alter MJ | 2005 | Lancet Infect Dis2005，5，9： | 1 |
| 16 | Firm diversification andCEO compensation : Managerial ability or executive entrench-ment? 显示文摘 | Rose N L Shepard A | 1997 | Rand Journal of Economics1997，，28： | 1 |
| 17 | Global epidemiology of hepatitis C infection显示文摘 | Shepard CW Finelli L Alter MJ | | 0，，9： | 1 |
| 18 | The subspace projected approximate matrix (SPAM) modification of the Davidson method显示文摘 | Shepard R Wagner A F Tilson J L | 2001 | Journal of Computational Physics2001，172，2： | 1 |
| 19 | Sustained attention and impulsivity in children with Tourette' s syndrome : comorbid- ity and confounds 显示文摘 | Sherman EM Shepard L Joschko M | 1998 | J Clin Exp Neuropsychol1998，20，5： | 1 |
| 20 | Hepatitis B virus infec-tion:Epidemiology and vaccination显示文摘 | Shepard CW Simard EP Finelli L | | 0，，02： | 1 |
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