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| 1 | Impact of 5-Fu/oxaliplatin on mouse dendritic cells and synergetic effect with a colon cancer vaccine显示文摘Objective: The aim of the present study was to investigate the effects of 5-fluorouracil(5-Fu) and oxaliplatin on the function and activation pathways of mouse dendritic cells(DCs), and to clarify whether 5-Fu/oxaliplatin combined with the CD1d-MC38/α-galactosylceramide(α-GC) tumor vaccine exhibits synergistic effects on the treatment of colon cancer in mice.Methods: The combination of the Toll like receptor(TLR) ligands and/or 5-Fu/oxaliplatin was added into myeloid-derived DCs in vitro culture. DC phenotypic changes were detected by flow cytometry, and the secretion of DC cytokines was detected by cytometric bead array(CBA). A MC38 mouse colon cancer model was constructed and the DCs were isolated from the spleen, tumor tissue and lymph nodes following intraperitoneal injection of 5-Fu/oxaliplatin. The cell phenotypes were detected by flow cytometry. The tumor infiltrating leukocytes,splenocytes and lymph node cells were co-cultured with the dead MC38 tumor cells, and the secretion levels of interferon-γ(IFN-γ) were detected. 5-Fu/oxaliplatin combined with our previously developed CD1d-MC38/α-GC tumor vaccine was used to inhibit the growth of MC38 colon cancer in mice, and the tumor growth rate and survival time were recorded.Results: 5-Fu/oxaliplatin exerted no significant effect on the expression of the stimulating phenotypes of DCs in vitro, while it could reduce the expression of programmed death ligand 1/2(PD-L1/L2) and promote interleukin-12(IL-12) secretion by DCs. Furthermore 5-Fu/oxaliplatin was beneficial to the differentiation of T-helper 1(Th1) cells. 5-Fu/oxaliplatin further enhanced the stimulating phenotypic expression of DCs in tumor bearing mice, decreased PD-L1/L2 expression, and specifically activated the lymphocytes. The CD1d-MC38/α-GC tumor vaccine combined with 5-Fu/oxaliplatin could exert a synergistic role that resulted in a significant delay of the tumor growth rate, and an increase in the survival time of tumor bearing mice.Conclusions: 5-Fu/oxaliplatin decreased the expression of the DC inhibitory phenotypes PD-L1/L2, promoted DC phenotypic maturation in tumor bearing mice, activated the lymphocytes of tumor bearing mice, and exerted synergistic effects with the CD1d-MC38/α-GC colon cancer tumor vaccine. | Xinqiang Hong Tiangeng Dong Tuo Yi Jianwei Hu Zhen Zhang Shengli Lin Weixin Niu | 2018 | Chinese Journal of Cancer Research2018，30，2： | 4 |
| 2 | Experimental study on the phase change behavior of phase change material confined in pores显示文摘 | Dong Zhang Shengli Tian Deyan Xiao | 2006 | Solar Energy2006，，5： | 2 |
| 3 | Affine groups and flag-transitive triplanes显示文摘Let D be a nontrivial 2-(v, k, 3) symmetric design (triplane) and let G≤Aut(D) be flag-transitive and point-primitive. In this paper, we prove that if G is an affine group, then G≤AΓL1(q), where q is some power of a prime p and p≥5. | DONG HuiLi ZHOU ShengLi | 2012 | Science China Mathematics2012，55，12： | 2 |
| 4 | Identity-Based Conditional Proxy Re-Encryption显示文摘 | ZHOU Dehua CHEN Kefei LIU Shengli ZHENG Dong | 2013 | Chinese Journal of Electronics2013，22，1： | 2 |
| 5 | Effects of moisture content or particle size on the in situ degradability of maize silage and alfalfa haylage in lactating dairy cows显示文摘A study using four Holstein cows with ruminal cannulas was conducted to evaluate the degradability of different moisture content or particle size of maize silage and alfalfa haylage. The maize silage(MS; 20-mm length) and alfalfa haylage(AH; 40-mm length) samples were wet(wet maize silage, MSW;wet alfalfa haylage, AHW), dried(dried maize silage, MSD; dried alfalfa haylage, AHD), or ground to pass through a 2.5-mm screen(dried ground maize silage, MSG; dried ground alfalfa haylage, AHG). Samples were incubated in the rumen for 2, 6.12, 24.36.48, and 72 h. Cows were fed ad libitum and allowed free access to water. High moisture content treatment of MSW expressed a lower rinsing NDF and ADF degradability at 2 h(P < 0.05) compared with dried samples(MSD and MSG). Different moisture content and particle size had a significant impact(P < 0.05) on the NDF degradability at 72 h, ADF degradability at36.48, and 72 h, and ruminally degradable ADF. All of the highest values were observed in small particle size and low moisture content AHG treatment. Based on this study, sample processing, such as drying and grinding, should be considered when evaluating nutritive values of forages. | Yang Zou Shuangzhao Dong Yun Du Shengli Li Yajing Wang Zhijun Cao | 2016 | Animal Nutrition2016，，3： | 1 |
| 6 | Characterization and hydroisomerization performance of SAPO-11 molecular sieves synthesized in different media显示文摘 | Zhang Shengzhen Chen Shengli Dong Peng | 2007 | Applied Catalysis A:General2007，332，1： | 1 |
| 7 | Synthesis,characterization and hydroisomerization catalytic performance of nanosize SAPO-1 1 molecular sieves显示文摘 | Zhang Shenzhen Chen Shengli Dong Peng | 2007 | Catalysis Letters2007，118，12： | 1 |
| 8 | TEM Examination and Mechanism of the Formation of Monosize Colloidal Silica Spheres 显示文摘 | Dong Peng (董鹏) Yang Guanghua (杨光华) | 1998 | Journal of Inorganic Material (无机材料学报)1998，13，3： | 1 |
| 9 | Endolysins as Antimicrobials显示文摘 | Daniel C. Nelson Mathias Schmelcher Lorena Rodriguez-Rubio Jochen Klumpp David G. Pritchard Shengli Dong David M. Donovan | 2012 | Advances in Virus Research2012，，： | 1 |
| 10 | Characterization and hydroisomerization performance ofSAPO-11 molecular sieves synthesized indifferent media 显示文摘 | Zhang Shengzhen Chen Shengli Dong Peng | 2007 | Applied Catalysis A: General2007，332，： | 1 |
| 11 | Diffusion coeffi- cient of petroleum residue fractions in a SiO2 model catalyst 显示文摘 | Liu Ziyuan Chen Shengli Dong Peng | 2009 | Energy & Fuels2009，23，6： | 1 |
| 12 | Precise regulation of acid pretreatment for red mud SCR catalyst:Targeting on optimizing the acidity and reducibility显示文摘Red mud(RM),as an alkaline waste,was recently proved to be a promising substitute for the SCR catalyst.Dealkalization could improve the acidity and reducibility of red mud,which were critical for SCR reaction.However,the dealkalization effect depended on the reaction between acid solution and red mud.In this study,we realized the directional control of the chemical state of active sites through tuning the acid pretreatment(dealkalization)process.The pretreatment endpoint was controlled at pH values of 3–5 with diluted nitric acid.When the pH values of red mud were 3 and 5(CRM-3 and CRM-5),activated catalysts showed NOx conversion above 90%at 275℃–475℃.The high initial reaction rate,Ce^(3+)/(Ce^(3+)+Ce^(4+))ratio,and surface acidity accounted for the excellent SCR performance of CRM-5 catalyst.Meanwhile,more Fe^(3+) on the CRM-3 surface improved the NH_(3) adsorption.There was a strong interaction between Al and Fe in both CRM-5 and CRM-3 catalysts.DFT results showed that the adsorption capacity of the Al-O_(3)-Fe for NH_(3) and NO is stronger than that of Fe-O_(3)-Fe,which enhanced the NOx conversion of the catalyst.However,the almandine was formed in CRM-4,consumed part of Fe^(3+) and Al^(3+),and the interaction between Al and Fe was weakened.Also,deposited almandine on the catalyst surface covered the active sites,thus leading to lower NH_(3)-SCR activity. | Xiang Zhang Yue Xuan Bin Wang Chuan Gao Shengli Niu Gaiju Zhao Dong Wang Junhua Li Chunmei Lu John C.Crittenden | 2022 | Frontiers of Environmental Science & Engineering2022，16，7： | 1 |
| 13 | Characterization and hydroisomerization performance of SA- PO-11 molecular sieves synthesized in different media显示文摘 | ZHANG Shengzhen CHEN Shengli DONG Peng | 2007 | Appl Catal A2007，33，2： | 1 |
| 14 | Characterization and hydroisomerization performance of SAPO-11 molecular sieves synthesized in different media显示文摘 | Zhang Shengzhen Chen Shengli Dong Peng | 2007 | Appl Catal A2007，33，2： | 1 |
| 15 | Measurement of diffusion coefficient of heavy oil in FCC catalysts 显示文摘 | Liu Ziyuan Chen Shengli Dong Peng | 2010 | Energy & Fuels2010，24，5： | 1 |
| 16 | Fabrication of Macro-porous β-zeolite by Using Colloidal Polystyrene Spheres as a Template显示文摘A β-zeolite/polystyrene composite material was synthesized by co-deposition of mono-disperse polystyrene spheres and nano β-zeolite particles in aqueous suspension on a vertical substrate. Macro-porous β-zeolite was obtained after the polystyrene template was removed by calcination. The micro/macro-pore structure of the prepared β-zeolite was highly ordered. In comparison with other assembly methods, the co-deposition method could obtain a highly ordered macro-porous material with relatively large zeolite filling particles, and therefore the co-deposition of particles with different size is a promising method for the fabrication of macro-porous materials. | Qi Yanping Dong Peng Chen Shengli Wang Xiaodong | 2006 | Petroleum Science2006，3，2： | 1 |
| 17 | Characterization and hydroisomerization performance of SAPO - 11 molecular sieves synthesized in different media 显示文摘 | Zhang Shengzhen Chen Shengli Dong Peng | 2007 | Appl Catal A : Gen2007，332，： | 1 |
| 18 | Characteriza- tion and hydroisomerization performance of SAPO-11 mo- lecular sieves synthesized in different media 显示文摘 | ZHANG S CHEN Shengli DONG P | 2007 | Applied Catalysis A: General2007，332，1： | 1 |
| 19 | Experimental study on the phase change behavior of phase change material confined in pores显示文摘 | Dong Zhang Shengli Tian Deyan Xiao | 2006 | Solar Energy2006，，5： | 1 |
| 20 | Monodisperse SiO2/TiO2 coreshell colloidal spheres:synthesis and ordered selfassembling 显示文摘 | Liu Renxiao Dong Peng Chen Shengli | 2005 | Chemistry Letters2005，34，54： | 1 |
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