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| 1 | BEAK-SHAPED GRAIN 1/TRIANGULAR HULL 1,a DUF640 gene,is associated with grain shape,size and weight in rice显示文摘Grain shape and size both determine grain weight and therefore crop yield.However,the molecular mechanisms controlling grain shape and size are still largely unknown.Here,we isolated a rice mutant,beak-shaped grain1(bsg1),which produced beak-shaped grains of decreased width,thickness and weight with a loosely interlocked lemma and palea that were unable to close tightly.Starch granules were also irregularly packaged in the bsg1 grains.Consistent with the lemma and palea shapes,the outer parenchyma cell layers of these bsg1 tissues developed fewer cells with decreased size.Map-based cloning revealed that BSG1 encoded a DUF640 domain protein,TRIANGULAR HULL 1,of unknown function.Quantitative PCR and GUS fusion reporter assays showed that BSG1 was expressed mainly in the young panicle and elongating stem.The BSG1 mutation affected the expression of genes potentially involved in the cell cycle and GW2,an important regulator of grain size in rice.Our results suggest that BSG1 determines grain shape and size probably by modifying cell division and expansion in the grain hull. | YAN DaWei ZHOU Ya YE ShengHai ZENG LongJun ZHANG XiaoMing HE ZuHua | 2013 | Science China(Life Sciences)2013，56，3： | 20 |
| 2 | Heat-sensitive moxibustion attenuates the inflammation after focal cerebral ischemia/ reperfusion injury显示文摘Heat-sensitive moxibustion has neuroprotective effects against focal cerebral ischemia/reperfusion injury, however its mechanism of action remains unclear. In this study, rat models of focal cerebral ischemia/reperfusion injury were treated with suspended moxibustion at acupoint Dazhui (DU14) for 35 minutes. Results showed that suspended moxibustion decreased infarct volume, reduced cortical myeloperoxidase activity, and suppressed serum levels of proinflammatory cytokines in rats with focal cerebral ischemia/reperfusion injury. Our experimental findings indicated that heat-sensitive moxibustion can attenuate inflammation and promote repair after focal cerebral ischemia/reperfusion injury. | Aijiao Xiao Rixin Chen: Mingfei Kang Shenghai Tan | 2012 | Neural Regeneration Research2012，7，33： | 10 |
| 3 | Effects of biochar on water movement characteristics in sandy soil under drip irrigation显示文摘Biochar addition can improve the physical and hydraulic characteristics of sandy soil.This study investigated the effects of biochar on water holding capacity and water movement in sandy soil under drip irrigation.By indoor simulation experiments,the effects of biochar application at five levels(0%,1%,2%,4%and 6%)on the soil water retention curve,infiltration characteristics of drip irrigation and water distribution were tested and analyzed.The results showed that biochar addition rate was positively correlated with water holding capacity of sandy soil and soil available water.Within the same infiltration time,with an increasing amount of added biochar,the diffusion distance of the horizontal wetting front(HWF)tended to decrease,while the infiltration distance of vertical wetting front(VWF)initially declined and then rose.The features of wetted bodies changed from'broad-shallow'to'narrow-deep'type.The relationship between the transport distances of HWF and VWF and the infiltration time was described by a power function.At the same distance from the point source,the larger the amount of added biochar,the higher the soil water content.Biochar had a great influence on the water content of the layer with biochar(0–200 mm)and had some effects at 200–250 mm without biochar;but it had less influence on the soil water content deeper than 250 mm.For the application rate of biochar of 4%,most water was retained within 0–250 mm soil layer.However,when biochar application amount was high(6%),it would be helpful for water infiltration.During the improvement of sandy soil,biochar application rate of 4%in the plow layer had the best effect. | PU Shenghai LI Guangyong TANG Guangmu ZHANG Yunshu XU Wanli LIPan FENG Guangping DING Feng | 2019 | Journal of Arid Land2019，11，5： | 6 |
| 4 | Characterization and mapping of a novel mutant sms1 (senescence and male sterility 1) in rice显示文摘Plant senescence plays diverse important roles in development and environmental responses.However,the molecular basis of plant senescence is remained largely unknown.A rice spontaneous mutant with the character of early senescence and male sterility (sms) was found in the breeding line NT10-748.In order to identify the gene SMS1 and the underlying mechanism,we preliminarily analyzed physiological and biochemical phenotypes of the mutant.The mutant contained lower chlorophyll content compared with the wild type control and was severe male sterile with lower pollen viability.Genetic analysis showed that the mutant was controlled by a single recessive gene.By the map-based cloning approach,we fine-mapped SMS1 to a 67 kb region between the markers Z3-4 and Z1-1 on chromosome 8 using 1,074 F2 recessive plants derived from the cross between the mutant sms1 (japonica) × Zhenshan 97 (indica),where no known gene involved in senescence or male sterility has been identified.Therefore the SMS1 gene will be a novel gene that regulates the two developmental processes.The further cloning and functional analysis of the SMS1 gene is under way. | Wenyi Yan Shenghai Ye Qingsheng Jin Longjun Zeng Yu Peng Dawei Yan Weibing Yang Donglei Yang Zuhua He Yanjun Dong Xiaoming Zhang | 2010 | Journal of Genetics and Genomics2010，37，1： | 6 |
| 5 | Sediment pollution characteristics and in situ control in a deep drinking water reservoir显示文摘Sediment pollution characteristics, in situ sediment release potential, and in situ inhibition of sediment release were investigated in a drinking water reservoir. Results showed that organic carbon(OC), total nitrogen(TN), and total phosphorus(TP) in sediments increased from the reservoir mouth to the main reservoir. Fraction analysis indicated that nitrogen in ion exchangeable form and Na OH-extractable P(Fe/Al-P) accounted for 43% and 26% of TN and TP in sediments of the main reservoir. The Risk Assessment Code for metal elements showed that Fe and Mn posed high to very high risk. The results of the in situ reactor experiment in the main reservoir showed the same trends as those observed in the natural state of the reservoir in 2011 and 2012; the maximum concentrations of total OC, TN, TP, Fe,and Mn reached 4.42 mg/L, 3.33 mg/L, 0.22 mg/L, 2.56 mg/L, and 0.61 mg/L, respectively. An in situ sediment release inhibition technology, the water-lifting aerator, was utilized in the reservoir. The results of operating the water-lifting aerator indicated that sediment release was successfully inhibited and that OC, TN, TP, Fe, and Mn in surface sediment could be reduced by 13.25%, 15.23%, 14.10%, 5.32%, and 3.94%, respectively. | Zizhen Zhou Tinglin Huang Yang Li Weixing Ma Shilei Zhou Shenghai Long | 2017 | Journal of Environmental Sciences2017，29，2： | 6 |
| 6 | Determination of DNA single-strand breaks by low-energy heavy ion and analysis of dose-effect curves显示文摘Calf thymus DNA was exposed to low-energy heavy ions (N+) and 60Co-γ-rays, and the dose-effect on DNA single-strand breaks (SSB) has been investigated. The results indicate that the dose-effect curve by N+ irradiation is different from that of conventional ionizing radiation. While the curve from γ-irradiation follows exponential type, the effect curve produced by N+ ion is of 'saddle type'. The yield of DNASSB per dose unit per DNA unit remained at a certain level under different doses of γ-rays. In contrast, the DNASSB at low dosage region of N+ showed an obvious peak before it decreased rapidly to a lower level. | Yanhua Du Shenghai Huang Zheng Tan Yingzhi Lin Guanying Qiu | 1999 | Chinese Science Bulletin1999，44，8： | 5 |
| 7 | Design and Accuracy Analysis of a Metamorphic CNC Flame Cutting Machine for Ship Manufacturing显示文摘The current research of processing large size fabrication holes on complex spatial curved surface mainly focuses on the CNC flame cutting machines design for ship hull of ship manufacturing. However, the existing machines cannot meet the continuous cutting requirements with variable pass conditions through their fixed configuration, and cannot realize high-precision processing as the accuracy theory is not studied adequately. This paper deals with structure design and accuracy prediction technology of novel machine tools for solving the problem of continuous and high-precision cutting. The needed variable trajectory and variable pose kinematic characteristics of non-contact cutting tool are figured out and a metamorphic CNC flame cutting machine designed through metamorphic principle is presented. To analyze kinematic accuracy of the machine, models of joint clearances, manufacturing tolerances and errors in the input variables and error models considering the combined effects are derived based on screw theory after establishing ideal kinematic models. Numerical simulations, processing experiment and trajectory tracking experiment are conducted relative to an eccentric hole with bevels on cylindrical surface respectively. The results of cutting pass contour and kinematic error interval which the position error is from –0.975 mm to +0.628 mm and orientation error is from –0.01 rad to +0.01 rad indicate that the developed machine can complete cutting process continuously and effectively, and the established kinematic error models are effective although the interval is within a ‘large' range. It also shows the matching property between metamorphic principle and variable working tasks, and the mapping correlation between original designing parameters and kinematic errors of machines. This research develops a metamorphic CNC flame cutting machine and establishes kinematic error models for accuracy analysis of machine tools. | HU Shenghai ZHANG Manhui ZHANG Baoping CHEN Xi YU Wei | 2016 | Chinese Journal of Mechanical Engineering2016，29，5： | 3 |
| 8 | Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca^(2+) ions and L-tryptophan显示文摘The human calcium-sensing receptor(CaSR)is a class C G protein-coupled receptor(GPCR)responsible for maintaining Ca^(2+)homeostasis in the blood.The general consensus is that extracellular Ca^(2+)is the principal agonist of CaSR.Aliphatic and aromatic L-amino acids,such as L-Phe and L-Trp,increase the sensitivity of CaSR towards Ca^(2+)and are considered allosteric activators.Crystal structures of the extracellular domain(ECD)of CaSR dimer have demonstrated Ca^(2+)and L-Trp binding sites and conformational changes of the ECD upon Ca^(2+)/L-Trp binding.However,it remains to be understood at the structural level how Ca^(2+)/L-Trp binding to the ECD leads to conformational changes in transmembrane domains(TMDs)and consequent CaSR activation.Here,we determined the structures of full-length human CaSR in the inactive state,Ca^(2+)-or L-Trp-bound states,and Ca^(2+)/L-Trp-bound active state using single-particle cryo-electron microscopy.Structural studies demonstrate that L-Trp binding induces the closure of the Venus flytrap(VFT)domain of CaSR,bringing the receptor into an intermediate active state.Ca^(2+)binding relays the conformational changes from the VFT domains to the TMDs,consequently inducing close contact between the two TMDs of dimeric CaSR,activating the receptor.Importantly,our structural and functional studies reveal that Ca^(2+)ions and L-Trp activate CaSR cooperatively.Amino acids are not able to activate CaSR alone,but can promote the receptor activation in the presence of Ca^(2+).Our data provide complementary insights into the activation of class C GPCRs and may aid in the development of novel drugs targeting CaSR. | Shenglong Ling Pan Shi Sanling Liu Xianyu Meng Yingxin Zhou Wenjing Sun Shenghai Chang Xing Zhang Longhua Zhang Chaowei Shi Demeng Sun Lei Liu Changlin Tian | 2021 | Cell Research2021，31，4： | 3 |
| 9 | Formation of superthick Al-based amorphous ribbon显示文摘The Al-Ni-La-Ce-Pr-Nd amorphous ribbon with a super-thickness of 140 mm has been produced by the melt spinning technique. The thickness is as twice as that achieved by the melt spinning technique in the corresponding period (the largest thickness of 65 mm). The crystallization was characterized by using a differential scanning calorimetry. The activation energies are calculated based on the Kissinger equation and the effects of the La, Ce, Pr and Nd on the glass forming ability of Al-based alloy are discussed in the paper. | WANG Shenghai, BIAN Xiufang & JIA Yubo Key Lab of Liquid Structure and Heredity of Materials, Ministry of Education of China, South Campus of Shandong University, Jinan 250061, China | 2003 | Chinese Science Bulletin2003，48，19： | 2 |
| 10 | The preventive effect of vaccine prophylaxis on severe respiratory syncytial virus infection:A meta-analysis显示文摘Respiratory syncytial virus(RSV) is the key underlying cause of acute lower respiratory tract infection in infants; however, no licensed vaccine against RSV infection is currently available. This study was undertaken to assess the preventive effect of vaccine on RSV infection. In this metaanalysis, 1,792 published randomized clinical trials of RSV vaccines from Jan 1973 to Sep 2015 were examined. Among thirteen studies that met the inclusion criteria, eleven studies estimated the impact of RSV vaccines and four studies estimated the effect of adjuvants. The odds ratios(ORs) were 0.31(95% CI, 0.15–0.67) and 0.62(95% CI, 0.29–1.34), respectively. We found that RSV subunit vaccines can significantly reduce the incidence of RSV infection and that whether vaccination with adjuvant therapy was an effective strategy still remained to be studied. This analysis of the preventive effect of vaccines on RSV infection has direct applications for the prevention of RSV infections. | Tongna Zhu Chuanlong Zhang Li Yu Jingxian Chen Huan Qiu Weiwei Lyu Shenghai Huang | 2015 | Virologica Sinica2015，30，5： | 2 |
| 11 | Fate and protective effect of marrow stromal cells after subretinal transplantation显示文摘髓 stromal 房间(MSC ) 的嫁接为退化疾病作为一条治疗学的途径被建议了。在这研究,我们与评估移植 MSC 的使用对待网膜的退化的目的在生活视网膜调查了命运和 grafted MSC 的动态进步。约 | Hong Pan Xinjian Liu Jihong Wu Yuhua Tian Shenghai Zhang Zhixin Lin Qian Huang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，3： | 2 |
| 12 | Seasonal transition characteristics of the westerly jet: Study based on field observations at an altitude of 6900 m on the Mt. Xixiabangma Dasuopu glacier显示文摘To better understand ultra-high-altitude climate characteristics and their changes, an automatic weather station was installed on August 4, 2005 on the Mt. Xixiabangma Dasuopu glacier (28°23.04′N, 85°43.72′E, 6900 m a.s.l.) in the middle of the Himalayas. Mountain weather conditions were observed continuously and automatically. This paper is the first to publish meteorological data for a whole year for a high-elevation region, and analyze wind direction, wind speed, air temperature, air pressure and humidity. Analysis of the observation data reveals that this region was strongly influenced by the westerly jet from October 10, 2005 to April 21, 2006 and by the Indian monsoon from May to September. The seasonal transitions of the westerly jet were characterized by changes in meteorological elements. In winter, influenced by the westerly jet, the wind speed in the study region was very high and fluctuated violently, gale days were frequent, temperature and air pressure fluctuated dramatically, the diurnal range of temperature decreased and the diurnal range of air pressure increased, relative humidity and specific humidity declined sharply, and air was dry. In summer, influenced by the Indian monsoon, the relative humidity and specific humidity were high. In addition, we analyzed reanalysis data for the location of the automatic weather station. The results confirmed that this region was strongly affected by the westerly jet from October 10, 2005 to April 21, 2006 and the observations that the seasonal transitions of the westerly jet were characterized by changes in meteorological elements. | LI ShengHai YAO TanDong TIAN LiDe WANG PengLing | 2011 | Chinese Science Bulletin2011，56，18： | 2 |
| 13 | A Preliminary Study on the Datong Fault Belt显示文摘The Datong fault belt is a NE trending fault in the northern Qinghai-Xizang (Tibet) Plateau and controls the boundary of the Xining Basin and Datong Basin. It consists of the Maziying-Miaogou (F_1) fault and the Laoye Mountain-Nanmenxia fault (F_2). There is obvious displacement in vertical direction along the belt. The field investigation results show that this belt has long-term activity. There are several meters long crushed zones and veins along the fault side in the basement rock. On the fault section,the Cambria system thrusts over the red-brick-colored Quaternary Period gravel,and there is a fault gouge of several centimeters thick developed on the fault plane. The fault gouge date (ESR) on the fault plane is 610±61ka. The covering deluvial loess is not dislocated,and the OSL result is 14.6±1.5ka. So it can be concluded that the fault belt was active in the middle Pleistocene,but inactive in the late Pleistocene according to the age data and geomorphologic features. Interior formations of the Datong basin features fold with the major axis orienting northwest. According to the relation of fault and fold deformation,Datong fault is a transversal tear,which is due to uneven compression of the folds in different parts and NNE trending regional compressive stress. It is common among the NE trending faults in the northeast of Qinghai-Xizang (Tibet) Plateau. These NE trending faults aren't large,and most are located in the active plate. They are all nearly vertical to the axis of the folds and compressive basins. | Li Zhimin Tian Qinjian Yao Shenghai Li Wenqiao Chen Youshun Zou Haining Gao Zhanwu | 2008 | Earthquake Research in China2008，22，3： | 2 |
| 14 | Chitin and chitosan dissolvedin ionic liquids as reversible sorbents of CO2显示文摘 | Xie Haibo Zhang Suobo Li Shenghai | 2006 | Green Chemistry2006，，8： | 1 |
| 15 | 显示文摘 | Li Shenghai Zhang Suobo Wang Xianhong | 2008 | Langmuir2008，24，10： | 1 |
| 16 | The technology and welding joint properties of hybrid laser-tig welding on thick plate显示文摘 | Zhang Shenghai Shen Yifu Qiu Huijuan | 2013 | Optics and Laser Technology2013，，： | 1 |
| 17 | Novel thin-film composite membranes with improved water flux from sulfonated cardo poly (arylene ether sulfone)bearing pendant amino groups 显示文摘 | Guang Chen Shenghai Li Xiaosa Zhang | 2008 | Journal of Membrane Science2008，310，： | 1 |
| 18 | I- onic liquids as novel solvents for the dis- solution and blending of wool keratin fi- bers 显示文摘 | Xie I-Iaibo Li Shenghai Zhang Suobo | 2005 | Green Chem2005，7，18： | 1 |
| 19 | Adaptive Pose Output Decoupling for a Hydraulically-driven 6-DOF Parallel Ma- nipulator显示文摘 | YAO Jianjun FU Wei HU Shenghai | 2010 | Journal of Vibration and Control2010，17，9： | 1 |
| 20 | Chitin and chitosan dissolved in ionic liquids as reversible sorbents of CO2 显示文摘 | Xie Haibo Zhang Suobo Li Shenghai | 2006 | Green Chemistry2006，8，： | 1 |
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