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| 1 | Gene association study with SVM,MLP and cross-validation for the diagnosis of diseases显示文摘Gene association study is one of the major challenges of biochip technology both for gene diagnosis where only a gene subset is responsible for some diseases,and for the treatment of the curse of dimensionality which occurs especially in DNA microarray datasets where there are more than thousands of genes and only a few number of experiments(samples).This paper presents a gene selection method by training linear support vector machine(SVM)/nonlinear MLP(multilayer perceptron)classifiers and testing them with cross-validation for finding a gene subset which is optimal/suboptimal for the diagnosis of binary/multiple disease types.Genes are selected with linear SVM classifier for the diagnosis of each binary disease types pair and tested by leave-one-out cross-validation;then,genes in the gene subset initialized by the union of them are deleted one by one by removing the gene which brings the greatest decrease of the generalization power,for samples,on the gene subset after removal,where generalization is measured by training MLPs with leave-one-out and leave-four-out cross-validations.The proposed method was tested with experiments on real DNA microarray MIT data and NCI data.The result shows that it outperforms conventional SNR method in the separability of the data with expression levels on selected genes.For real DNA microarray MIT/NCI data,which is composed of 7129/2308 eective genes with only 72/64 labeled sam-ples belonging to 2/4 disease classes,only 11/6 genes are selected to be diagnostic genes.The selected genes are tested by the classification of samples on these genes with SVM/MLP with leave-one-out/both leave-one-out and leave-four-out cross-validations.The result of no misclassification indicates that the selected genes can be really considered as diagnostic genes for the diagnosis of the corresponding diseases. | Junying Zhang Shenling Liu Yue Wang | 2008 | Progress in Natural Science:Materials International2008，18，6： | 12 |
| 2 | Spatial and temporal variations of two cyanobacteria in the mesotrophic Miyun reservoir, China显示文摘Spatial variations in phytoplankton community within a large mesotrophic reservoir(Miyun reservoir, North China) were investigated in relation to variations in physico-chemical properties, nutrient concentrations, temperature and light conditions over a 5 month period in 2009. The dynamics of phytoplankton community was represented by the dominance of cyanobacteria through summer and fall, following with a short term dominance of chlorophyta in late fall, and a relatively high abundance of diatom in October; on the other hand, maximum phytoplankton biomass was recorded in the north shallow region of Miyun reservoir with a higher nutrients level. Particular attention was paid to the impacts of environmental conditions on the growth of two cyanobacteria genera, the toxin-producing Microcystis and the taste & odor-producing Oscillatoria. Microcystis biomass was in general greatly affected by water temperature and mixing depth/local water depth ratio in this reservoir, while the Oscillatoria biomass in the surface and middle layers was greatly affected by total dissolved phosphorus, and that in the bottom layer was related with the Secchi depth/local water depth ratio. Abundant Oscillatoria biomass was observed only in late September when Microcystis biomass decreased and allowed sufficient light go through. | Ming Su Jianwei Yu Shenling Pan Wei An Min Yang | 2014 | Journal of Environmental Sciences2014，26，2： | 9 |
| 3 | Application of shape analysis to mammographic calcifications显示文摘 | ShenL RangayyanRM DesautelsJEL | 1993 | IEEETransMI1993，13，2： | 1 |
| 4 | Atmospheric distribution and long-range transport behavior of organichlorine pesticides in North America 显示文摘 | ShenL Wania F Lei Y D | 2005 | Environ Sci Teehnol2005，39，2： | 1 |
| 5 | An experimental study of oil recovery from sewage sludge by low -temperature pyrolysis in a fluidized bed显示文摘 | ShenL Zhang D K | 2003 | Fuel2003，8，4： | 1 |
| 6 | FrequencyofSCA1SCA2SCA3/MJDSCA6SCA7andDRPLACAGtrinucleotidere-peatexpansioninpatientswithhereditaryspinocerebellarataxiafrom Chinesekindreds显示文摘 | TangB LiuC ShenL etal | 2000 | ArchNeurol2000，57，4： | 1 |
| 7 | Experession of p53 protein in nasopharyngeal carcinoma 显示文摘 | ShenL F Chen A Tseng HH | 1994 | J Pathol1994，172，3： | 1 |
| 8 | Human Telomerase Reverse Transeriptase-Speeific T-Helper Responses Induced by Promiscuous Major Histocom- patibility Complex Class II-Restricted 显示文摘 | Roland Schroersl Lei Shenl Lisa Rollins | 2003 | Epitopes Clinical Cancer Research2003，9，： | 1 |
| 9 | Perioperative pharmacological management of choroidaI detachment associat- ed with rhegmatogenous retinal detachment 显示文摘 | ShenL' 'Iao-J SunSl)ong YChen-Y Cheng L | 2015 | Acta Ophthal- mo12015，122，3： | 1 |
| 10 | An examination on the waste management practice in the local construction site显示文摘 | ShenL Y TamW Y V ChanC W S | 2002 | Hong Kong Surveyor2002，13，1： | 1 |
| 11 | Arginaseinductionbyheattreatmentcontributestoameliorationofchillingin-juryandactivationofantioxidantenzymesintomatofruit显示文摘 | ZHANGXH SHENL LIFJ etal | 2013 | PostharvestBiolTec2013，79，： | 1 |
| 12 | UpdateofresearchontheroleofEZH2incancerprogression显示文摘 | SHENL CUIJ LIANGS etal | 2013 | OncoTargetsTher2013，4，： | 1 |
| 13 | Comparative Mapping of QTLs for Agronomic Traits of Rice Across Environments Using a Doubled Haploid Population 显示文摘 | Lu C ShenL Tan Z etal | 1996 | Thero Appl Genet1996，93，8： | 1 |
| 14 | EffectofDachengqidecoctiononNF-kappaBp65expressioninlungofratswithpartialintestinalobstructionandtheunderlyingmechanism显示文摘 | YangS ShenL JinY etal | 2010 | JHuazhongUnivSciTechnologMedSci2010，30，2： | 1 |
| 15 | Application of shape analysis to mammographic calcifications显示文摘 | RangayyanRM DesautelsJEL | 1993 | IEEE Trans MI1993，13，2： | 1 |
| 16 | 显示文摘 | ZhouJ (周剑锋) SongY (宋叉虎) ShenL (沈烈) ZhengQ (郑强) | 2004 | 功能材料2004，35，03： | 1 |
| 17 | Asufficientconditionforaplanargraphtobe3-choosable显示文摘 | ShenL WangY | 2007 | InformProcessLett2007，104，4： | 1 |
| 18 | Planargraphswithoutcyclesoflength4,7,8,or9are3-choosable显示文摘 | WangY ShenL | 2010 | DiscreteMath2010，159，4： | 1 |
| 19 | A general approach for analysis and application discrete mulfiwavelet transforms显示文摘 | ThamJY ShenL LeeSetal | 2000 | IEEE Trans on Signal Processing2000，48，2： | 1 |
| 20 | The reduction of greenhouse gas emissions from freight transport by pooling supply chains显示文摘 | Shenle Pan EricBallot Frederic Fontane | 2010 | Production Economics2010，10，： | 1 |
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