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| 1 | Cancer Ig G, a potential prognostic marker, promotes colorectal cancer progression显示文摘Objective: Currently, no satisfactory targets for colorectal cancer or markers for immunotherapy and diagnosis and prognosis are available. Immunoglobulin G(Ig G) is widely expressed in many cancers, and it promotes cancer progression. This study explored the role of cancer-derived Ig G(CIg G) in colorectal cancer.Methods: First, using a monoclonal antibody to CIg G, we examined the expression levels of CIg G in colorectal cancer cell lines by western blot and immunofluorescence analyses and in tissue specimens by immunohistochemistry. Second, the variable region gene was amplified by nested polymerase chain reaction(PCR), and PCR products were sequenced and analyzed. Third, we investigated the effect of CIg G on colorectal cancer cells by cell proliferation, wound healing, migration and invasion assays, and colony formation assay. Fourth, we performed in vivo tumorigenicity experiments to explore the effect of CIg G on tumorigenicity. Finally, we used RNA-seq analysis and co-immunoprecipitation experiments to further clarify possible mechanisms of CIg G.Results: We found that CIg G is widely expressed in colorectal cancer cells, and the overexpression of CIg G indicates significantly poor colorectal cancer prognosis. Furthermore, CIg G knockdown significantly inhibits the proliferation, migration and invasion ability of cells, and tumor growth in vivo. RNA-seq analysis indicated that CIg G knockdown results primarily in changes in expression of apical junction and epithelial-mesenchymal transition-related genes. CIg G may be involved in colorectal cancer invasion and metastasis through interacting with E-cadherin.Conclusions: CIg G is a potential human oncogene in colorectal cancer and that it has potential for application as a novel target in targeted therapy and a marker for prognostic evaluation. | Hongpeng Jiang Boxi Kang Xinmei Huang Yichao Yan Shan Wang Yingjiang Ye Zhanlong Shen | 2019 | Chinese Journal of Cancer Research2019，31，3： | 2 |
| 2 | The influence of water removal on the strength and toughness of cortical bone 显示文摘 | NYMAN J S ROY A SHEN Xinmei | 2006 | J Biomech2006，39，5： | 1 |
| 3 | Precise large deviations for sums of random vectors with dependent components of consistently varying tails显示文摘让 { X i =(X 1, i ,...,X m, i ), i 1 } 是独立、相等分布式的 nonnegative 的一个序列 m 维的随机的向量。这些向量的边缘的分布一致地有变化的 univariate 尾巴和有限工具。这里, X 1 的部件被允许到通常依赖者。而且,让 N (?? | Xinmei SHEN Yuqing NIU Hailan TIAN | 2017 | Frontiers of Mathematics in China2017，12，3： | 1 |
| 4 | Precise large deviations for randomly weighted sums of negatively dependent random variables with consistently vary- ing tails显示文摘 | Shen Xinmei Lin Zhengyan | 2008 | Statist Probab Lett2008，78，： | 1 |
| 5 | Approximation of the tail probability of randomly weighted sums and applications显示文摘 | Zhang Yi Shen Xinmei Weng Chengguo | 2009 | Stochastic Processes and their applications2009，119，： | 1 |
| 6 | Approximation of the tail probability of randomly weighted sums and applications 显示文摘 | Zhang Yi Shen Xinmei Weng Chengguo | 2009 | Stochastic Processes and their applications2009，119，： | 1 |
| 7 | Spin-Modulated Oxygen Electrocatalysis显示文摘The electrocatalysis reactions involving oxygen,such as oxygen evolution reaction(OER)and oxygen reduction reaction(ORR),play a critical role in energy storage/conversion applications,e.g.,fuel cells,metal-air batteries,and electrochemical water splitting.The high kinetic energy barrier of the OER/ORR is highly associated with the spin state interconversion between singlet OH^(−)/H_(2)O and triplet O_(2),which is influenced by the spin state and magnetism of catalysts.This Review summarizes recent progress and advances in understanding spin/magnetism-related effects in oxygen electrocatalysis to develop spin theory.It is demonstrated that the spin states(low,intermediate,and high spin)of magnetic transition metal catalysts(TMCs)can directly affect the reaction barriers of OER/ORR by tailoring the bonding of oxygen intermediates with TMCs.Besides,the spin states of TMCs can build a spin-selective channel to filter the electron spins required for the single/triplet interconversion of O species during OER/ORR.In this Review,we introduced many approaches to modulating spin state,for instance,altering the crystal field,oxidation state of active-site ions,and the morphology of TMCs.What’s more,a magnetic field can drive the spin flip of magnetic ions to achieve the spin alignment(↑↑)(i.e.,facilitating spin polarization),which will strengthen the spin selectivity for accelerating the filtration and transfer of the spins with the same direction for the generation and conversion of triplet ↑O=O↑.Importantly,the origin of magnetic field enhancement on OER/ORR are deeply discussed,which provides a great vision for the magnetism-assisted catalysis.Finally,the challenges and perspectives for future development of spin/magnetism catalysis are presented.This Review is expected to highlight the significance of spin/magnetism theory in breaking the bottleneck of electrocatalysis field and promote the development of high-efficientcy electrocatalysts for practical applications. | Zhi Fang Wanting Zhao Tong Shen Daping Qiu Yucheng Lv Xinmei Hou Yanglong Hou | 2023 | Precision Chemistry2023，1，7： | 0 |
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