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| 1 | Advances in healthcare wearable devices显示文摘Wearable devices have found numerous applications in healthcare ranging from physiological diseases,such as cardiovascular diseases,hypertension and muscle disorders to neurocognitive disorders,such as Parkinson’s disease,Alzheimer’s disease and other psychological diseases.Different types of wearables are used for this purpose,for example,skin-based wearables including tattoobased wearables,textile-based wearables,and biofluidic-based wearables.Recently,wearables have also shown encouraging improvements as a drug delivery system;therefore,enhancing its utility towards personalized healthcare.These wearables contain inherent challenges,which need to be addressed before their commercialization as a fully personalized healthcare system.This paper reviews different types of wearable devices currently being used in the healthcare field.It also highlights their efficacy in monitoring different diseases and applications of healthcare wearable devices(HWDs)for diagnostic and treatment purposes.Additionally,current challenges and limitations of these wearables in the field of healthcare along with their future perspectives are also reviewed. | Sheikh M.A.Iqbal Imadeldin Mahgoub E Du Mary Ann Leavitt Waseem Asghar | 2021 | npj Flexible Electronics2021，5，1： | 6 |
| 2 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 3 | Stiffened steel plates under combined compression and bending 显示文摘 | Sheikh I A Elwi A E Grondin G Y | 2003 | Journal of Constructional Steel Research2003，59，： | 1 |
| 4 | Utility of vol- ume adjusted prostate specific antigendensity in the diagnosis of prostate cancer in Arab men显示文摘 | SHEIKH M AL SAEED O KEHINDE E O | 2005 | Int Urol Nephrol2005，37，4： | 1 |
| 5 | Im- age quality assessment: From error visibility to structural similarity显示文摘 | Wang Z Bovik A C Sheikh H R Simoncelli E P | 2004 | IEEE Transaction on Image Processing2004，13，4： | 1 |
| 6 | Numerical evaluation of the behavior of steel and FRP confined concrete columns using compression field modeling显示文摘 | Montoya E Vecchio F J Sheikh S A | 2004 | Engineering Structures2004，26，11： | 1 |
| 7 | Rapid upregulation of endothelial P-selectin expression via reactive oxygen species generation显示文摘 | Takano M Meneshian A Sheikh E | 2002 | Am J Physiol Heart Circ Physiol2002，283，： | 1 |
| 8 | Biological activities of fibroblast growth factor-2 in the adult myocardium显示文摘 | DETILLIEUX KA SHEIKH F KARDAMI E | 2003 | Cardiovasc Res2003，57，1： | 1 |
| 9 | Neural networks and blood cell identification显示文摘 | Sheikh H Zhu B | 1997 | J Med Syst1997，21，4： | 1 |
| 10 | Utility of volume adjusted prostate specific antigen density in the diagnosis of prostate cancer in Arab men显示文摘 | SHEIKH M AL-SAEED O KEHINDE E O | 2005 | Int Urol Nephrol2005，37，4： | 1 |
| 11 | Numerical evaluation of the behaviour of steel-and FRP-confined concrete columns using compression field modelling显示文摘 | MONTOYA E VECCHIO F J SHEIKH S A | 2004 | Engineering Structures2004，26，11： | 1 |
| 12 | Transcriptional regulation of FGF-2 gene expression in cardiac myocytes 显示文摘 | Jimenez SK Sheikh F Jin Y Detillieux KA Dhaliwal J Kardami E | 2004 | Cardiovasc Res2004，62，3： | 1 |
| 13 | Image quality assessment: from error visibility to structural similarity显示文摘 | Wang Z Bovik A C Sheikh H R and Simoncelli E P | 2004 | IEEE Transactions on Image Processing2004，13，4： | 1 |
| 14 | Computational e- valuation and experimental in vitro antibacterial, antifungal and antiviral activity of bis-Schiff bases of isatin and its derivatives显示文摘 | Jarrahpour A Sheikh J Mounsi I E | 2013 | Med Chem Res2013，22，3： | 1 |
| 15 | Anaphylaxis: the acute episode and beyond 显示文摘 | Simons F E Sheikh A | 2013 | BMJ2013，346，： | 1 |
| 16 | Meningioma in children: a report of nine cases and review of the literature 显示文摘 | Sheikh BY Siqueira E Dayel F | 1996 | Surg Neurol1996，45，： | 1 |
| 17 | The prevalence, burden, and treatment of severe, frequent, and migraine headaches in US minority populations : sta- tistics from National Survey studies显示文摘 | Loder S Sheikh HU Loder E | 2015 | Headache2015，55，2： | 1 |
| 18 | Capsule endoscopy's impact on clinical management and outcomes:a single-center experience with 145 patients显示文摘 | Toy E Rojany M Sheikh R | 2008 | Am J Gastroenterol2008，103，12： | 1 |
| 19 | Neural networks and blood cell identification 显示文摘 | Micheli-Tzanakou E Sheikh H Zhu B | 1997 | Journal of Medical Systems1997，21，4： | 1 |
| 20 | Glucocorticoids for the treatment of anaphylaxis 显示文摘 | Choo K J Simons F E Sheikh A | 2013 | Evid Based Child Health2013，8，4： | 1 |
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