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| 1 | Exosomes: new molecular targets of diseases显示文摘细胞外的泡(EV ) 包括 apoptotic 身体, microvesicles 和 exosomes,并且他们象 diseased 状态一样在正常在 cell-to-cell 通讯作为关键管理者表演。EV 包含自然货物分子,例如 miRNA, mRNA 和蛋白质,并且通过循环把这些功能的货物转移到附近的房间或更多的远房间。这些机能上地活跃的分子然后影响不同发信号的串联。传送到接受者房间的消息依赖于 EV 的作文,它由父母房间和 EV 生物的续生说是坚定的。因为他们象在循环, biocompatibility,低 immunogenicity 和毒性的增加的稳定性那样的性质, EV 为治疗学作为吸引人的交货系统引起了注意。这评论在为治疗学的目的使用 exosomes 在治疗和潜在的优点和挑战集中于 exosomes 的功能的使用。 | Saheli SAMANTA Sheeja RAJASINGH Nicholas DROSOS Zhigang ZHOU Buddhadeb DAWN Johnson RAJASINGH | 2018 | Acta Pharmacologica Sinica2018，39，4： | 27 |
| 2 | MicroRNAs in neuroblastoma tumorigenesis,therapy resistance,and disease evolution显示文摘Neuroblastoma(NB)deriving from neural crest cells is the most common extra-cranial solid cancer at infancy.NB originates within the peripheral sympathetic ganglia in adrenal medulla and along the midline of the body.Clinically,NB exhibits significant heterogeneity stretching from spontaneous regression to rapid progression to therapy resistance.MicroRNAs(miRNAs,miRs)are small(19-22 nt in length)non-coding RNAs that regulate human gene expression at the post-transcriptional level and are known to regulate cellular signaling,growth,differentiation,death,stemness,and maintenance.Consequently,the function of miRs in tumorigenesis,progression and resistance is of utmost importance for the understanding of dysfunctional cellular pathways that lead to disease evolution,therapy resistance,and poor clinical outcomes.Over the last two decades,much attention has been devoted to understanding the functional roles of miRs in NB biology.This review focuses on highlighting the important implications of miRs within the context of NB disease progression,particularly miRs’influences on NB disease evolution and therapy resistance.In this review,we discuss the functions of both the“oncomiRs”and“tumor suppressor miRs”in NB progression/therapy resistance.These are the critical components to be considered during the development of novel miR-based therapeutic strategies to counter therapy resistance. | Natarajan Aravindan Karthikeyan Subramanian Dinesh Babu Somasundaram Terence S.Herman Sheeja Aravindan | 2019 | Cancer Drug Resistance2019，2，4： | 3 |
| 3 | A comparative study between pure and Al-containing amor-hous carbon films prepared by FCVA technique together with high substrate pulse biasing显示文摘 | SHEEJA D TAY B K SZE Y | 2003 | Diamond Relat Mater2003，12，： | 1 |
| 4 | Use of Box - Behken design of experiments for the adsorption of verofix - redusing biopolymer显示文摘 | ANNADURAI G SHEEJA R Y | 1998 | Biop Rocess Eng1998，18，6： | 1 |
| 5 | Micromachining of large area amorphous carbon mem-branes prepared by filtered cathodic vacuum arc technique显示文摘 | LIUJIANG YU TAY B K SHEEJA D | 2004 | Applied Surface Science2004，223，： | 1 |
| 6 | Undergraduate students’ perceptions of digital library: A case study显示文摘 | N.K. Sheeja | 2010 | The International Information & Library Review2010，，3： | 1 |
| 7 | Tribological properties and adhesive strength of DLC coatings prepared under different substrate bias voltages显示文摘 | SHEEJA D TAY B K LAU S P | 2001 | Wear2001，249，： | 1 |
| 8 | On Stress Reduction of Tetrahedal Amorphous Carbon Films for Moving Mechanical Assemblies显示文摘 | Sheeja D YU L J | 2003 | Diamond Relat Mater2003，12，： | 1 |
| 9 | Study of mechanical properties and stress of tetrahedral amorphous carbon films prepared by pulse biasing显示文摘 | ZHANG Y B LAU S P SHEEJA D | 2005 | Surf Coat Technol2005，195，： | 1 |
| 10 | Cheong Effect of frequency and pulse width on the properties of ta:C films pre pared by FCVA together with substrate pulse biasing显示文摘 | SHEEJA D TAY B K YU L J | 2002 | Thin Solid Films2002，，： | 1 |
| 11 | Antiangiogenic activity of andrographis paniculata extract and andrographolide 显示文摘 | K Sheeja C Guruvayoorappan G Kuttan | 2006 | Int Immunopharmacol2006，10，： | 1 |
| 12 | Long-term influence of leguminous cover crops on the biochemical properties of a sandy clay loam Fluventic Sulfaquent in a humid tropical region of India 显示文摘 | Dinesh R Suryanarayana MA Chaudhuri SG Sheeja TE | 2004 | Soil Tillage Res2004，77，1： | 1 |
| 13 | Use of Box--Behken design of Experiments for the adsorption of vero fix-- redusing Biopolymer显示文摘 | Annadurai G Sheeja R Y | 1998 | BioproeessEng1998，18，： | 1 |
| 14 | Photocatalyt- ic activity of La-doped ZnO for the degradation of monocroto- phos in aqueous suspension显示文摘 | Anandan S Vinu A Sheeja Lovely K L P | 2007 | J Mol Catal A: Chem2007，266，： | 1 |
| 15 | Characterization of ta-C films prepared by a two-step filtered vacuum are deposition technique显示文摘 | SHEEJA D TAY B K LAU S P | 2000 | Surf Coat Technol2000，127，： | 1 |
| 16 | Photocatalyticactivity of La-doped ZnO for the degradation of monocroto-phos in aqueous suspension 显示文摘 | Anandan S Vinu A Sheeja L K LP | 2007 | J Mol Catal A : Chem2007，266，12： | 1 |
| 17 | Biodegradation of diesel oil by an Arabian Sea sediment culture isolated from the vicinity of an oil field显示文摘 | Suparna Mukherji* Sheeja Jagadevan Gita Mohapatra Avinash Vijay | 2004 | Bioresource Technology2004，95，： | 1 |
| 18 | Tribological characterization of surface modified UHMWPE against DLC-coated Co- Cr-Mo 显示文摘 | Sheeja D Tay B K Nung L N | 2005 | Surf Coat Techn2005，190，： | 1 |
| 19 | Analysis of the association be- tween interleukin- 1 beta (+3954) gene polymorphism and chronic periodo- ntitis显示文摘 | Padmalatha O Sheeja V Sankari M | 2009 | Indian J Dent Res2009，20，1： | 1 |
| 20 | Characterization of Ta-C films prepared by a two-step filtered vacuum arc deposition technique显示文摘 | Sheeja D Tay B K Lau S P | 2000 | Surface and Coatings Technology2000，12，： | 1 |
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