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| 1 | Toll- like receptors and their adapter molecules 显示文摘 | Tukhvatulin AI Logunov DY Shcherbinin DN | 2010 | Biochemistry(Mosc)2010，75，9： | 1 |
| 2 | An enhancement of quantitative accuracy of the SPECT/CT activity distribution reconstructions: Physical phantom experiments显示文摘 | SHCHERBININ S CELLER A | 2010 | Comput Med Imaging Graph2010，34，34： | 1 |
| 3 | Accuracy of quantitative reconstructions in SPECT/CT imaging显示文摘 | SHCHERBININ S CELLER A BELHOCINE T | 2008 | Phys Med Biol2008，53，： | 1 |
| 4 | Development of adenoviral vector-based mucosal vaccine against influenza显示文摘 | Tutykhina I L Logunov D Y Shcherbinin D N | 2011 | J Mol Med2011，89，2001： | 1 |
| 5 | Calculation of the magnetic field of surface defects显示文摘 | Zatsepin N N Shcherbinin V E | 1966 | J NDT1966，2，： | 1 |
| 6 | Influence of the extension of a defect on the magnitude its magnetic field 显示文摘 | SHCHERBININ V PASHAGIN A | 1972 | Defektoskopija1972，8，： | 1 |
| 7 | Numerical study of thermal and electric fields of a magnesium electrolyric cell显示文摘 | Shcherbinin S A Yakovleva G A Kazylov A K | 1994 | Tsvetnye Metally1994，，6： | 1 |
| 8 | Mathematical simulation of three-dimensional thermal and electric fields of magnesium electrolyzer显示文摘 | Shcherbinin S A Fazylov A R Yakovleva G A | 1997 | Tsvetnye Metally1997，，5： | 1 |
| 9 | Mathematical simulation of gas-hydrodynamic processes in a magnesium electrolyzer显示文摘 | Agalakov V V Shcherbinin S A Yakovleva G A | 1997 | Tsvetnye Metally1997，，7： | 1 |
| 10 | Patient-Specific Radiation Dosimetry of ^sup 99m^Tc-HYNIC-TyF^sup 3^-Octreotide in Neuroendocrine Tumors显示文摘 | Grimes Joshua Celler Anna Birkenfeld Bozena Shcherbinin Sergey Listewnik Maria H Piwowarska-Bilska Hanna Mikolajczak Renata Zorga Piotr | 2011 | The Journal of Nuclear Medicine2011，，： | 1 |
| 11 | On the development of national standards for magnetic and eddy- current nondestructive inspection of steel pipes 显示文摘 | Shcherbinin V Blinov Y Shleenkov A S | 2009 | Russ J Nondestr Test2009，45，10： | 1 |
| 12 | Molecular and cellular changes in the post-traumatic spinal cord remodeling after autoinfusion of a genetically-enriched leucoconcentrate in a mini-pig model显示文摘Post-traumatic spinal cord remodeling includes both degenerating and regenerating processes,which affect the potency of the functional recovery after spinal cord injury(SCI).Gene therapy for spinal cord injury is proposed as a promising therapeutic strategy to induce positive changes in remodeling of the affected neural tissue.In our previous studies for delivering the therapeutic genes at the site of spinal cord injury,we developed a new approach using an autologous leucoconcentrate transduced ex vivo with chimeric adenoviruses(Ad5/35)carrying recombinant cDNA.In the present study,the efficacy of the intravenous infusion of an autologous genetically-enriched leucoconcentrate simultaneously producing recombinant vascular endothelial growth factor(VEGF),glial cell line-derived neurotrophic factor(GDNF),and neural cell adhesion molecule(NCAM)was evaluated with regard to the molecular and cellular changes in remodeling of the spinal cord tissue at the site of damage in a model of mini-pigs with moderate spinal cord injury.Experimental animals were randomly divided into two groups of 4 pigs each:the therapeutic(infused with the leucoconcentrate simultaneously transduced with a combination of the three chimeric adenoviral vectors Ad5/35‐VEGF165,Ad5/35‐GDNF,and Ad5/35‐NCAM1)and control groups(infused with intact leucoconcentrate).The morphometric and immunofluorescence analysis of the spinal cord regeneration in the rostral and caudal segments according to the epicenter of the injury in the treated animals compared to the control mini-pigs showed:(1)higher sparing of the grey matter and increased survivability of the spinal cord cells(lower number of Caspase-3-positive cells and decreased expression of Hsp27);(2)recovery of synaptophysin expression;(3)prevention of astrogliosis(lower area of glial fibrillary acidic protein-positive astrocytes and ionized calcium binding adaptor molecule 1-positive microglial cells);(4)higher growth rates of regeneratingβIII-tubulin-positive axons accompanied by a higher number of oligodendrocyte transcription factor 2-positive oligodendroglial cells in the lateral corticospinal tract region.These results revealed the efficacy of intravenous infusion of the autologous genetically-enriched leucoconcentrate producing recombinant VEGF,GDNF,and NCAM in the acute phase of spinal cord injury on the positive changes in the post-traumatic remodeling nervous tissue at the site of direct injury.Our data provide a solid platform for a new ex vivo gene therapy for spinal cord injury and will facilitate further translation of regenerative therapies in clinical neurology. | Maria Aleksandrovna Davleeva Ravil Rasimovich Garifulin Farid Vagizovich Bashirov Andrei Aleksandrovich Izmailov Leniz Faritovich Nurullin Ilnur Ildusovich Salafutdinov Dilara Zilbarovna Gatina Dmitrij Nikolaevich Shcherbinin Andrei Aleksandrovich Lysenko Irina Leonidovna Tutykhina Maksim Mikhailovich Shmarov Rustem Robertovich Islamov | 2023 | Neural Regeneration Research2023，18，7： | 1 |
| 13 | Accuracy of quantitative reconstructions in SPECT/CT imaging显示文摘 | Shcherbinin S Celler A Belhocine T | 2008 | Phys Med Biol2008，53，17： | 1 |
| 14 | Influence of the extension of a defect on the magnitude of its magnetic field显示文摘 | Shcherbinin V E Pashagin A I | 1972 | Defektoskopiya1972，8，4： | 1 |
| 15 | Creating technical heritage object replicas in a virtual environment显示文摘论文为创造虚拟技术遗产复制品论述创新信息科学方法,它一般来说研究人员具有重要科学、实际的重要性到不仅而且到公众。由执行 3D 建模和飞机,飞船,建筑上工程的大楼,和另外的技术对象的动画,当为未来代支持复制品的保藏时,学习的进程被完成。现代途径基于计算机技术的宽用法吸引很多年轻人探索科技的历史并且在 mechanical engineering 的领域里更新他们的兴趣。 | Olga EGOROVA Dmitry SHCHERBININ | 2016 | Frontiers of Mechanical Engineering2016，11，1： | 0 |
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