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| 1 | Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2显示文摘Receptor recognition and subsequent membrane fusion are essential for the establishment of successful infection by SARS-CoV-2.Halting these steps can cure COVID-19.Here we have identified and characterized a potent human monoclonal antibody,HB27,that blocks SARS-CoV-2 attachment to its cellular receptor at sub-nM concentrations.Remarkably,HB27 can also prevent SARS-CoV-2 membrane fusion.Consequently,a single dose of HB27 conferred effective protection against SARS-CoV-2 in two established mouse models.Rhesus macaques showed no obvious adverse events when administrated with10 times the effective dose of HB27.Cryo-EM studies on complex of SARS-CoV-2 trimeric S with HB27 Fab reveal that three Fab fragments work synergistically to occlude SARS-CoV-2 from binding to the ACE2 receptor.Binding of the antibody also restrains any further conformational changes of the receptor binding domain,possibly interfering with progression from the prefusion to the postfusion stage.These results suggest that HB27 is a promising candidate for immuno-therapies against COVID-19. | Ling Zhu Yong-Qiang Deng Rong-Rong Zhang Zhen Cui Chun-Yun Sun Chang-Fa Fan Xiaorui Xing Weijin Huang Qi Chen Na-Na Zhang Qing Ye Tian-Shu Cao Nan Wang Lei Wang Lei Cao Huiyu Wang Desheng Kong Juan Ma Chunxia Luo Yanjing Zhang Jianhui Nie Yao Sun Zhe Lv Neil Shaw Qianqian Li Xiao-Feng Li Junjie Hu Liangzhi Xie Zihe Rao Youchun Wang Xiangxi Wang Cheng-Feng Qin | 2021 | National Science Review2021，8，3： | 3 |
| 2 | High Elevation Energy and Water Balance:the Roles of Surface Albedo and Temperature显示文摘Observation and modeling of the coupled energy and water balance is the key to understand hydrospheric and cryospheric processes at high elevation.The paper summarizes the progress to address this aspect in relation with different earth system elements,from glaciers to wetlands.The energy budget of two glaciers,i.e.Xiao Dongkemadi and Parlung No.4,was studied by means of extended field measurements and a distributed model of the coupled energy and mass balance was developed and evaluated.The need for accurate characterization of surface albedo was further documented for the entire Qinghai Tibet Plateau by numerical experiments with Weather Research and Forecast(WRF)on the sensitivity of the atmospheric boundary layer to the parameterization of land surface processes.A new approach to the calibration of a coupled distributed watershed model of the energy and water balance was demonstrated by a case study on the Heihe River Basin in northwestern China.The assimilation of land surface temperature did lead to the retrieval of critical soil and vegetation properties as the soil permeability and the canopy resistance to the exchange of vapour and carbon dioxide.The retrievals of actual Evapo-Transpiration(ET)were generated by the ETMonitor system and evaluated against eddy covariance measurements at sites spread throughout Asia.As regards glacier response to climate variability,the combined findings based on satellite data and model experiments showed that the spatial variability of surface albedo and temperature is significant and controls both glacier mass balance and flow.Experiments with both atmospheric and hydrosphere-cryosphere models documented the need and advantages of using accurate retrievals of land surface albedo to capture lan-atmosphere interactions at high elevation. | Massimo MENENTI Li JIA Marco MANCINI Xin LI Francesca PELLICCIOTTI Kun YANG Jiancheng SHI Maria Jose ESCORIHUELA Chiara CORBARI Shaoting REN Chunfeng MA Chaolei ZHENG Lian LIU Thomas SHAW Baohong DING Wei YANG | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 3 |
| 3 | Recent Progress in Atmospheric Chemistry Research in China: Establishing a Theoretical Framework for the “Air Pollution Complex”显示文摘Atmospheric chemistry research has been growing rapidly in China in the last 25 years since the concept of the“air pollution complex”was first proposed by Professor Xiaoyan TANG in 1997.For papers published in 2021 on air pollution(only papers included in the Web of Science Core Collection database were considered),more than 24000 papers were authored or co-authored by scientists working in China.In this paper,we review a limited number of representative and significant studies on atmospheric chemistry in China in the last few years,including studies on(1)sources and emission inventories,(2)atmospheric chemical processes,(3)interactions of air pollution with meteorology,weather and climate,(4)interactions between the biosphere and atmosphere,and(5)data assimilation.The intention was not to provide a complete review of all progress made in the last few years,but rather to serve as a starting point for learning more about atmospheric chemistry research in China.The advances reviewed in this paper have enabled a theoretical framework for the air pollution complex to be established,provided robust scientific support to highly successful air pollution control policies in China,and created great opportunities in education,training,and career development for many graduate students and young scientists.This paper further highlights that developing and low-income countries that are heavily affected by air pollution can benefit from these research advances,whilst at the same time acknowledging that many challenges and opportunities still remain in atmospheric chemistry research in China,to hopefully be addressed over the next few decades. | Tong ZHU Mingjin TANG Meng GAO Xinhui BI Junji CAO Huizheng CHE Jianmin CHEN Aijun DING Pingqing FU Jian GAO Yang GAO Maofa GE Xinlei GE Zhiwei HAN Hong HE Ru-Jin HUANG Xin HUANG Hong LIAO Cheng LIU Huan LIU Jianguo LIU Shaw Chen LIU Keding LU Qingxin MA Wei NIE Min SHAO Yu SONG Yele SUN Xiao TANG Tao WANG Tijian WANG Weigang WANG Xuemei WANG Zifa WANG Yan YIN Qiang ZHANG Weijun ZHANG Yanlin ZHANG Yunhong ZHANG Yu ZHAO Mei ZHENG Bin ZHU Jiang ZHU | 2023 | Advances in Atmospheric Sciences2023，40，8： | 2 |
| 4 | Racial difference in the outcomes of patients with diastolic heart failure显示文摘 | East MA Peterson ED Shaw LK | 2004 | Am Heart J2004，148，： | 1 |
| 5 | Autolngons fat injection into the vocal folds:technical consideration and long-term follow-up显示文摘 | Shaw GY Szewczyk MA Searle J | 1997 | Laryngoscope1997，107，： | 1 |
| 6 | Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis显示文摘 | Gibson SL Ma Z Shaw LM | 2007 | Cell Cycle2007，6，6： | 1 |
| 7 | Effect of simvastatin on high glucose-and angiotensin II-induced activation of the JAK/STAT pathway in mesangial cells显示文摘 | Banes-Berceli AK Shaw S Ma G | 2006 | Am J Physiol Renal Physiol2006，291，1： | 1 |
| 8 | Agenesis of the cor- pus callosum in California 1983-2003 : A population - based study 显示文摘 | Glass HC Shaw GM Ma C | 2008 | Am J Med Genet A2008，146，19： | 1 |
| 9 | Divergent roles for IBS-1and IBS-2 in breast cancer metastasis显示文摘 | Gibson SL Ma Z Shaw LM | 2007 | Cell Cycle2007，6，6： | 1 |
| 10 | A prospective clinical registry of ultrasound-guided regional anesthesia for ambulatory shoulder sur- gery显示文摘 | Liu SS Gordon MA Shaw PM | 2010 | Anesth Analg2010，111，3： | 1 |
| 11 | TUNEL-positive staining in white and grey matter after fatal head injury in man显示文摘 | MacKinnom MA Raghupathi R | 2001 | C1in Neuropathol2001，20，： | 1 |
| 12 | Effect of simvastatin on high glucose- and anglotensin Ⅱ-induced activation of the JAK/ STAT pathway in mesangial cells显示文摘 | Banes-Berceli AK Shaw S Ma G | 2006 | Am J Physiol Renal Physiol2006，291，1： | 1 |
| 13 | Exclusion of lung metastases in placental site trophoblastic tumor using fluorodeoxyglucose positron emission tomography:A case report 显示文摘 | Shaw SW Wang CW Ma SY | 2005 | Gynecol Oncol2005，99，： | 1 |
| 14 | Mutations in thehuman ortholog of Aristaless cause X-linked mental retardation and, epilepsy 显示文摘 | Str0mme P Mangelsdorf ME Shaw MA | 2002 | Nat Genet2002，30，4： | 1 |
| 15 | Mutations in the human ortholog of Aristaless cause X-linked mental retardation and epilepsy显示文摘 | Stromme P Mangelsdorf ME Shaw MA | 2002 | Nat Genet2002，30，： | 1 |
| 16 | Effect of simvastatin on high glucose- and angiotensin II-induced activation of the JAK/STAT pathway in mesangial cells显示文摘 | Banes-Bercell AK Shaw S Ma G | 2006 | Am J Physiol Renal Physiol2006，291，1： | 1 |
| 17 | Autologous fat injection into vocal folds: technical consideration and long-term follow-up 显示文摘 | Shaw GY Szewozyk MA Searle J | 1997 | Laryngoscope1997，107，： | 1 |
| 18 | Evaluation of functional outcomes (speech,swallowing and voice) in patients attending speech pathology after head and neck cancer treatment(s):development of a multi-centre database显示文摘 | Perry AR Shaw MA | | 0，，08： | 1 |
| 19 | Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions显示文摘 | Shaw RM Fay AJ Puthenveedu MA | | 0，，3： | 1 |
| 20 | Effect of simvastatin on high glucose and angiotensin 1I-induced activation of the JAK/STAT pathway in mesangial eells显示文摘 | Banes-Berceli AK Shaw S Ma G | 2006 | Am J Physiol Re- nal Physiol2006，291，1： | 1 |
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