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| 1 | Iron and liver fibrosis: Mechanistic and clinical aspects显示文摘Liver fibrosis is characterised by excessive deposition of extracellular matrix that interrupts normal liver functionality. It is a pathological stage in several untreated chronic liver diseases such as the iron overload syndrome hereditary haemochromatosis, viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and diabetes. Interestingly, regardless of the aetiology, iron-loading is frequently observed in chronic liver diseases. Excess iron can feed the Fenton reaction to generate unquenchable amounts of free radicals that cause grave cellular and tissue damage and thereby contribute to fibrosis. Moreover, excess iron can induce fibrosis-promoting signals in the parenchymal and non-parenchymal cells, which accelerate disease progression and exacerbate liver pathology. Fibrosis regression is achievable following treatment, but if untreated or unsuccessful, it can progress to the irreversible cirrhotic stage leading to organ failure and hepatocellular carcinoma, where resection or transplantation remain the only curative options. Therefore,understanding the role of iron in liver fibrosis is extremely essential as it can help in formulating iron-related diagnostic, prognostic and treatment strategies. These can be implemented in isolation or in combination with the current approaches to prepone detection, and halt or decelerate fibrosis progression before it reaches the irreparable stage. Thus, this review narrates the role of iron in liver fibrosis. It examines the underlying mechanisms by which excess iron can facilitate fibrotic responses. It describes the role of iron in various clinical pathologies and lastly,highlights the significance and potential of iron-related proteins in the diagnosis and therapeutics of liver fibrosis. | Kosha J Mehta Sebastien Je Farnaud Paul A Sharp | 2019 | World Journal of Gastroenterology2019，25，5： | 39 |
| 2 | Fetal assessment methods for improving neonatal and maternal outcomes in preterm prelabour rupture of membranes显示文摘 | Sharp GC Stock SJ Norman JE | 2014 | Cochrane Database Syst Rev2014，10，01： | 1 |
| 3 | A report-chronic fatigue syndrome: guidelines for research 显示文摘 | Sharpe MC Archard LC Banatvala JE | 1991 | Journal of the Royal Society of Medicine1991，84，： | 1 |
| 4 | Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization显示文摘 | Piletz JE Ivanov TR Sharp JD | 2000 | DNA Cell Biol2000，19，6： | 1 |
| 5 | The chemotherapy agent oxaliplatin impairs the renewal of fear to an extinguished condi tioned stimulus in rats显示文摘 | Sharpe MJ Fardell JE Vardy J | 2012 | Behav Brain Res2012，227，1： | 1 |
| 6 | Areport, chronic fatigue syndrome:guidelines for research显示文摘 | Sharpe MC Archard LC Banatvala JE | 1991 | Journal of the RoyalSoyal of Medicine1991，84，： | 1 |
| 7 | History of family suicide behaviors and negative problem solving in multiple suicide attempters显示文摘 | Jeglic EL Sharp IR Chapman JE | 2005 | Arch Suicide Res2005，9，2： | 1 |
| 8 | Cholesterol granuioma involving the temporal bone 显示文摘 | Sharp JE Terzis TF Issacson J | 2000 | Laryngol Otol2000，106，1： | 1 |
| 9 | Intra nasal administration of poly-laetie acid mierosphexe co-encapsulated Yersinia pestis subunits confers protection from pneumonic plague in the mouse 显示文摘 | Eyles JE Sharp GJ Williamson ED Spiers ID Alpar HO | 2008 | Vaccine2008，16，7： | 1 |
| 10 | Imidazoline receptor antisera-selected (IRAS)cDNA: cloning and characterization显示文摘 | Ivanov TR Sharp JD | 2000 | DNA Cell Biol2000，19，6： | 1 |
| 11 | Erythrocyte deformabihty is a nitric oxide-mediated factor in decreased capillary density during sepsis显示文摘 | Bateman RM Jagger JE Sharpe MD | 2001 | Am J Physiol Heart Circ Physiol2001，280，6： | 1 |
| 12 | Widespread vertical transmission and associated host sex- ratio distortion within the eukaryotic phylum Microspora 显示文摘 | Terry RS Smith JE Sharpe RG | 2004 | Proceedings of Royal Society Biological Sciences2004，271，1550： | 1 |
| 13 | Integron gene cassettes and degradation of compounds associated with industrial waste: The case of the Sydney tar ponds显示文摘 | Koenig JE Sharp C Dlutek M | 2009 | PLoS ONE2009，4，4： | 1 |
| 14 | Imidazoline receptor antisera -selected (I1 R) cDNA:cloning and characterization显示文摘 | Piletz JE Ivanov TR Sharp JD | 2000 | DNA Cell Biol2000，19，6： | 1 |
| 15 | Erythrocyte deformability is a nitric oxide-mediated factor in decreased capillary density during sepsis显示文摘 | Bateman RM Jagger JE Sharpe MD | 2001 | Am J Physiol Heart Circ Physiol2001，280，6： | 1 |
| 16 | Prevention and reversal of left ventricular remodelitg: summation显示文摘 | Konstam MA Udelson JE Sharpe N | 2002 | J Card Fail2002，8，6： | 1 |
| 17 | A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection显示文摘 | Buhlmann JE Elkin SK Sharpe AH | 2003 | J Immunol2003，170，11： | 1 |
| 18 | Erythrocyte defomiabilityis a nitric oxide-mediated factor in decreased capillary density duringsepsis 显示文摘 | Batenian KM Ja^er JE Sharpe MD | 2001 | Am J Physiol Heart Circ Physiol2001，280，6： | 1 |
| 19 | Changes in middle cerebral artery velocity after carotid endarterectomy do not identify patients at high-risk of suffering intracranial haemorrhage or stroke due to hyperperfusion syndrome 显示文摘 | Newman JE Ali M Sharpe R | 2013 | Eur J Vase Endovasc Surg2013，45，6： | 1 |
| 20 | Intravenous radionuclide cystograph for the detection of vesicoureteral reflux显示文摘 | Pollet JE Sharp PF Smith FW | 1998 | J Urol1998，125，1： | 1 |
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