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| 1 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 2 | HPLC Method Research of Picoplatin-a New Platinum Anti-cancer Drug and Its Impurities显示文摘Purpose: To establish a HPLC testing method of the content of bulk picoplatin and its impurities. Method: the separation was perform on a C18 column(4.6 mm×250 mm, 5 m) with potassium dihydrogen phosphate-aceton-itrile as the mobile phase at a flow rate of 1.0 mL/min. The detecting wavelength was set at 210 nm, and the column temperature was set at 30℃. Result: in the method validation, the linear relationship modulus of picoplatin is 0.9999, the systemic precision is 0.44%, the method precision is 0.74%, the average recovery rate is 99.62%, the LOD and LOQ of picoplatin is 0.2 ng and 1.0 ng. The average resolution of picoplatin and its impurities is more than 2. Conclusion: The established method is good specificity, high sensitivity, and good repeatability which could provide scientific evidence for the quality control of picoplatin and its impurities. | LUAN Chunfang CONG Yanwei ZHANG Qi QIU Xueweng BEI Yuxiang PU Shaoping | 2012 | 贵金属2012，33，A01： | 1 |
| 3 | Metabolic engineering for the production of copolyesters consisting of 3-hydroxybutyrate and 3-hydroxyhexanoate by Aeromonas hydrophila 显示文摘 | QIU Yuanzheng OUYANG Shaoping SHEN Zhongyao | 2004 | Macromol Biosci2004，4，： | 1 |
| 4 | Station-keeping control for a stratosphere airship via wind speed prediction approach显示文摘Purpose–The purpose of this paper is to improve the control precision of the station-keeping control for a stratosphere airship through the feedforward-feedback PID controller which is designed by the wind speed prediction based on the incremental extreme learning machine(I-ELM).Design/methodology/approach–First of all,the online prediction of wind speed is implemented by the I-ELM with rolling time.Second,the feedforward-feedback PID controller is designed through the position information of the airship and the predicted wind speed.In the end,the one-dimensional dynamic model of the stratosphere airship is built,and the controller is applied in the numerical simulation.Findings–Based on the conducted numerical simulations,some valuable conclusions are obtained.First,through the comparison between the predicted value and true value of the wind speed,the wind speed prediction based on I-ELM is very accurate.Second,the feedforward-feedback PID controller designed in this paper is very effective.Originality/value–This paper is very valuable to the research of a high-accuracy station-keeping control of stratosphere airship. | Jihui Qiu Shaoping Shen Zhibin Li | 2017 | International Journal of Intelligent Computing and Cybernetics2017，10，4： | 0 |
| 5 | How Challenge Stress Affects Mental Health among College Students during the COVID-19 Pandemic: The Moderating Role of Self-Efficacy显示文摘While a plethora of studies has been conducted to examine stress and its impact on mental health in western countries,research is scarce investigating the relationship between student challenge stress and health illness in the context of Chinese colleges.No studies examined the moderating effect of self-efficacy on the relationship between challenge stress and health illness.This study attempted to investigate the relationships between these three variables among Chinese college students.Especially,this study focused on examining whether self-efficacy moderated the effect of perceived challenge stress on students’mental health.Also,the differences were tested between male and female students in terms of these three variables.A sample of 578 Chinese college students was recruited over an approximately 12-week period from 7 Chinese universities.An online survey link was dis-tributed through WeChat.The SPSS version 26 software was used to analyze the data.Results showed that there is no significant difference between genders in terms of perceived challenge stress,self-efficacy,and students’mental health.In addition,challenge stress was positively related to the students’mental health(β=0.35,p<0.01)while there was a negative association between self-efficacy and mental health(β=-0.41,p<0.01).Furthermore,self-efficacy plays a moderating role in the relationship between challenge stress and mental health(β=-0.11,p=0.02).Students with low self-efficacy tend to experience more mental health issues.It is suggested that Chinese colleges and universities pay more attention to students with low self-efficacy,either through faculty/staff interven-tions or peer counseling.Professors consider reducing students’academic stress to improve their mental health. | Yan Zeng Shaoping Qiu Amin Alizadeh Tiefang Liu | 2021 | International Journal of Mental Health Promotion2021，23，2： | 0 |
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