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您的检索式：作者名="Shaolin Zeng"
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| 1 | A Small-Scale Medication of Leflunomide as a Treatment of COVID-19 in an Open-Label Blank-Controlled Clinical Trial显示文摘We recently reported that inhibitors against human dihydroorotate dehydrogenase(DHODH)have broad-spectrum antiviral activities including their inhibitory efficacies on SARS-CoV-2 replication in infected cells.However,there are limited data from clinical studies to prove the application of DHODH inhibitors in Coronavirus disease 2019(COVID-19)patients.In the present study,we evaluated Leflunomide,an approved DHODH inhibitor widely used as a modest immune regulator to treat autoimmune diseases,in treating COVID-19 disease with a small-scale of patients.Cases of 10 laboratory-confirmed COVID-19 patients of moderate type with obvious opacity in the lung were included.Five of the patients were treated with Leflunomide,and another five were treated as blank controls without a placebo.All the patients accepted standard supportive treatment for COVID-19.The patients given Leflunomide had a shorter viral shedding time(median of5 days)than the controls(median of 11 days,P=0.046).The patients given Leflunomide also showed a significant reduction in C-reactive protein levels,indicating that immunopathological inflammation was well controlled.No obvious adverse effects were observed in Leflunomide-treated patients,and they all discharged from the hospital faster than controls.This preliminary study on a small-scale compassionate use of Leflunomide provides clues for further understanding of Leflunomide as a potential antiviral drug against COVID-19. | Ke Hu Mengmei Wang Yang Zhao Yunting Zhang Tao Wang Zhishui Zheng Xiaochen Li Shaolin Zeng Dong Zhao Honglin Li Ke Xu Ke Lan | 2020 | Virologica Sinica2020，35，6： | 7 |
| 2 | X-ray Photoelectron Spectroscopy on Superconducting T_(12)CaBa_(2)Cu_(2)O_(8) Thin Film显示文摘We have prepared single-phase superconducting T_(12)CaBa_(2)Cu_(2)O_(8) thin film by dc magnetron sputtering process and measured X-ray photoelectron spectra of the film at room and liquid nitrogen temperatures.From the relative intensities of the Ba3d,Tl4f.O1 s and Cu2p spectra taken at different take-off angles,we have concluded that there is an adventitious contamination(nonsupercon-ducting phase)surface layer.After excluding contributions from these spurious phases,we have tentatively assigned which core-level shifts should be caused by the superconducting phase transition. | ZENG Wensheng QIU ping YAN Shaolin LI Zengfa ZHANG Guangyin | 1991 | Chinese Physics Letters1991，8，6： | 0 |
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