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| 1 | Microvascular pathological features and changes in related injury factors in a rat acute blood stasis model显示文摘OBJECTIVE: To examine the microvascular pathological characteristics and changes in related injury factors in a rat model of acute blood stasis.METHODS: A total of 75 Sprague-Dawley rats were divided randomly and equally into a control group and four experimental groups assessed at different times after the induction of stasis(0, 1, 3 or 6 h after stasis)(n = 15). The acute blood stasis model was established through rat tail-vein injection of high-molecular-weight dextran. After Electrocardiograph(ECG) detection at predetermined times(0,1, 3 and 6 h after induction of stasis), the rats were sacrificed and blood and cardiac samples were harvested for analysis. Hematoxylin-eosin(HE) staining and transmission electron microscopy were used for histopathological detection; an enzyme linked immunosorbent assay(ELISA) was used to detect thromboxane B2(TXB2) and 6-keto-prostaglandin F1α(6-Keto-PGF1α) concentrations; a real-time polymerase chain reaction(PCR) reaction system was used to detect intercellular adhesion molecule1(ICAM-1) and vascular cell adhesion molecule1(VCAM-1) m RNA expression; western blotting was used to detect vascular endothelial cadherin(VE-cadherin) protein expression.RESULTS: The ST segment in the ECG showed gradual elevation after induction of stasis and continued elevation at a high level at 3 and 6 h. The HE staining showed changes in myocardial cell necrosis and tissue dissociation after the induction of stasis, along with inflammatory infiltration. Results of transmission electron microscopy showed immediate changes in blood stasis and lumen occlusion in the microvasculature, along with endothelial cell swelling. After the induction of stasis, TXB2 concentrations gradually increased while 6-Keto-PGF1αconcentrations were immediately significantly reduced. The TXB2/6-Keto-PGF1αratio was maintained at a high level. ICAM-1 m RNA expression showed an unstable elevation while VCAM-1 m RNA expression was significantly reduced after the induction of stasis. Compared with the control group, VE-cadherin protein expression increased at 0 and 3 h after the induction of stasis, while no change occurred at 1 and 6 h.CONCLUSION: The pathological manifestations of acute blood stasis are microvascular blood retention, lumen stenosis and even occlusion. The condition is also called 'blood coagulation and weep' in Traditional Chinese Medicine. The blood stasis model resulted in the injury and necrosis of endothelial cells and cardiomyocytes, along with the presence of an imbalance of vasomotor factor levels, platelet activation, and increases in the expression of adhesion molecules and endothelial barrier dysfunction,which corresponds to 'blood failed to nourish' in Traditional Chinese Medicine. | Zhang Junxiu Feng Yu Li Shaodan, Liu Yi Zhang Yin Guo Yunxia Yang Minghui | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 5 |
| 2 | Changes in nitric oxide,angiotensinⅡ,angiopoietin-like protein 4 mRNA,neuregulin 1 mRNA,and platelet endothelial cell adhesion molecule-1 in rats with acute blood stasis induced by high-molecular-weight dextran显示文摘OBJECTIVE: To investigate the influence of acute blood stasis on nitric oxide(NO), angiotensin Ⅱ(Ang Ⅱ), angiopoietin-like protein 4(ANGPTL4)m RNA, neuregulin 1(NRG-1) m RNA, and platelet endothelial cell adhesion molecule-1(PECAM-1) in rats with stasis induced by high-molecular-weight dextran(HMWD).METHODS: Seventy-five Sprague Dawley rats were divided randomly into five groups(n = 15 in each group): control group, immediate group, 1 h group,3 h group, and 6 h group. A model of acute blood stasis was established via injection of HMWD into the tail vein. After performing electrocardiogram at the predetermined times according to the grouping, we collected blood and cardiac samples for hematoxylin-eosin(HE) staining and histopathological examination via transmission electron microscopy. Enzyme-linked immunosorbent assay was used to detect plasma levels of NO, AngⅡ, and fibrinogen. Real-time polymerase chain reaction was used to detect the expression of ANGPTL4 m RNA and NRG-1 m RNA. Immunohistochemical methods were used to detect PECAM-1 protein expression.RESULTS: The rat model of blood stasis showed blood retention in the capillary lumens. The ST segment showed gradual elevation, and was still elevated at 3 and 6 h after induction of blood stasis.HE staining showed myocardial cell necrosis and dissolution after modeling, along with basement membrane rupture and mitochondrial structural damage. Transmission electron microscopy showed endothelial cell swelling and an increase in absorption vesicles immediately after modeling. Endothelial cell apoptosis was increased at 3 and 6 h after modeling. Cardiac muscle fibers were disordered and intercalated discs were blurred immediately after modeling. There were massive numbers of dissolved cardiac muscle fibers, ruptured basement membranes, and mitochondrial structural damage at 3 and 6 h after modeling. NO plasma concentration was significantly reduced immediately and 1 h after modeling, while it was increased at 3 and 6 h.AngⅡ plasma concentration was decreased immediately after modeling, but increased at 1, 3, and6 h. Fibrinogen plasma concentration was significantly increased at immediate, 1, 3, and 6 h after modeling. PECAM-1 protein expression was obviously increased immediately after modeling, at 1, 6 h was found mild augment. Expression of Ang PTL4 m RNA was increased at immediate, 1, 3, and 6 h after modeling, and was found further augment at 3,and 6 h. Expression of NRG-1 m RNA was increased at immediate, 1, 3, and 6 h after modeling, and the strongest expression was at 1 h.CONCLUSION: The pathological manifestation of acute blood stasis is characterized by microvascular blood retention. Prolonged blood stasis leads to worsening endothelial cell and cardiomyocyte damage, along with imbalances in the expression of vasomotor factors and increased vascular tone.The pathological damage caused by blood stasis also promotes the expression of cell protection factors. | Feng Yu Zhang Junxiu Li Shaodan Liu Yi Zhang Yin Guo Yunxia Yang Minghui | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 3 |
| 3 | Separation and accumulation of Cu(Ⅱ),Zn(Ⅱ) and Cr(Ⅵ) from aqueous solution by magnetic chitosan modified with diethylenetria-mine显示文摘 | Li Haibo Bi Shaodan Liu Long | 2011 | Desalination2011，278，3： | 1 |
| 4 | Separation and ac- cumulation of Cu( I ), Zn( lI ) and Cr( V显示文摘 | Li Haibo Bi Shaodan Liu Long | 2011 | Desalination2011，278，3： | 1 |
| 5 | Short-time Fourier Transform Using Odd Symmetric Window Function显示文摘In this paper,a novel time–frequency(TF)analysis method,called the short-time Fourier transform using odd symmetric window function(OSTFT),is proposed using odd symmetric window function to replace the conventional even window function of STFT.Different from conventional STFT acquiring the amplitude maximum at time and frequency centers,OSTFT acquires the minimum amplitude of 0.Hence,OSTFT can obtain a TF representation(TFR)with high TF resolution by utilizing the leaked energy rather than restraining it.It is worth to mention that the proposed OSTFT can vitiate the effect of window size we choose on the TFR obtained.Furthermore,it also has a good performance on signals with complex instantaneous frequencies(IFs),even crossing IFs.Because we just replace the conventional window function of STFT,the time-consuming of the proposed OSTFT is at the same level as the conventional STFT.The effectiveness of proposed OSTFT has been validated on two complex multi-component simulated numerical signals and a signal collected from the brown bat. | Miaofen Li Youmin Liu Shaodan Zhi Tianyang Wang Fulei Chu | 2022 | Journal of Dynamics, Monitoring and Diagnostics2022，1，1： | 0 |
| 6 | Iof Efficacy and safety of anticoagulant therapy for preventing Secondary Thromboembolic Disease In Hypertensive Cerebral Hemorrhage显示文摘Objective Toevaluate the efficacy and safety of earlyanticoagulant treatment for preventing secondary thromboembolIC Disease in hypertensive intracerebral hemorrhage.Methodscases of hypertensivecerebral hemorrhage in We hospital from January 2013 to October 2014 were selectedas the subjects and divided/b221>into control group and prevention GROUP by using the random Table method , casesin each Group . The prevention group used low molecularhepa RIncalcium 5000U/DbyhypodErmICINJEt.[n]at the EARLy sTage of cERebRal hemorrhaGE(3-4d)for,D. the contRoL group wasgive NthecoNVentioNaL Treatm Entand nursing.NweredaIlydetEcTeD.THe pLaTeLeT count and blood coagulation function uLTRasonic Doppler annexation for double lower limbs deep Veins Was performedon 1,7,daftar antIcoagulaTioN therapy.THe vein THRomboSIS occurrence situation No flowER limbs In the two groups Was PeRf or Med ThecomPaRaTiveanalysis.THe paTients witH highly suspect TeDpulmona RyembolISM needed topeRFe CTT heexamI naTioNS of D-dimeR , lung Spiral CT eNHaNCed Scanning , ele CT rocardiogram(EKG) monitoring , etC.THehea DCT wasreex inEdona1m, 5,TenDafteR antICoagulaTioN therapy.Results LowER limb venoUS Thrombosis did not occurred paTientsof the PRevention group;which occurReD In 6 cases (%) of the contRoL group , 3 Cases Were In the paralytic Side4 Cases weRe located undeR the PopLiteal vein , 2 , caseshaD symptoms, 1 case was symptomatic pulmonary embolism all Cases embolism all CAses weRe recoveRed afteR antICoagulaTioN theRapy. The Twogroupsha DNos TatisTICaLdiffEreNCesIntHeaspEcTsof PLatele Tcount,bLooDcoagulaTioNfu nctionand Re-bleeding(P>0.).The incidence Rate oF Deep venoUS Thrombosis (DVT)and pulmonary embolism in'prevention Group prevention Group were 0 (0/20) and 0 (0/20) respectively,which were significantly lowerthan with significantly lower than 30%( 6/20 ) and 5%(1/20 ) in the controlgroup , differences significant ( P < 0.05 ). Conclusion Adopting early anticoagulant treatment? Safeand effective for preventing secondary thrombosis Disease in the patients with hypertension cerebral hemorrhage. | Tang Ping Wang shaodan Liang yantao Yu xuefang Liu daoxi | 2017 | Preventive Medicine Research2017，6，1： | 0 |
| 7 | The Dynamics of Interorganizational Collaboration in Disaster Management:A Network Study Based on Flood Disasters in China显示文摘Interorganizational collaboration networks have become an important tool for disaster management.However,research on how different organizations can effectively collaborate throughout the entire disaster management process in centralized states such as China is scarce.This study begins to fill this lacuna by investigating interorganizational collaboration in different phases of disaster management and analyzing changes in the structure of the networks constructed during the preparedness and response phases of the 2020 flood disaster in Hubei Province,China.Building on the complex adaptive systems(CAS)theory,we argue that interorganizational collaboration changes dynamically according to its tasks and requirements.In the preparedness phase,interorganizational collaborations primarily follow established plans and choose horizontal selforganized collaboration mechanisms.However,when the urgent information and resource requirements increase in the response phase,many organizations choose vertical mandatory collaboration mechanisms.We found that organizations at the central and provincial levels in China were well positioned to coordinate information and resources and strengthen the interorganizational collaboration and communication that is crucial in disaster management.These findings contribute to the study of interorganizational collaboration networks in disaster management. | Zhichao Li Long Liu Shaodan Liu | 2023 | International Journal of Disaster Risk Science2023，14，6： | 0 |
| 8 | Regulating the conductance of tungsten diselenide by oxygen plasma and improving its electrical stability by encapsulation显示文摘Two-dimensional(2D)tungsten selenide(WSe_(2))is promising candidate material for future electronic applications,owing to its potential for ultimate device scaling.For improving the electronic performance of WSe_(2)-based field-effect transistors(FETs),the modification of surface properties is essential.In this study,the seamless structural phase transition in WSe_(2) lattice is achieved by soft oxygen plasma,regulating the electrical conductance of WSe_(2)-based FETs.We found that during the soft oxygen plasma treatment with optimal processing time,the generated oxygen ions can substitute some selenium atoms and thus locally modify the bond length,inducing 2H→1T phase transition in WSe_(2) with seamless interfaces.The mosaic structures have been proven to tailor the electronic structure and increase the hole carrier concentration inside WSe_(2),significantly increasing the channel conductance of WSe_(2) FETs.With the further increase of the oxygen plasma treatment time,the creation of more selenium vacancy defects leads to the electronic doping,resulting in the reduction of conductance.Benefiting from the hexagonal boron nitride(h-BN)encapsulation to interrupt the partial structural relaxation from 1T to 2H phase,our WSe_(2) FET exhibits high electronic stability with conductance of 6.8×10^(-4) S,which is about four orders of magnitude higher than 2H WSe_(2)(5.8×10^(-8) S).This study could further broaden the WSe_(2) FETs in applications for functionalization and integration in electronics. | Zhaofang Cheng Shaodan He Shimin Zhang Shijun Duan Min Wang Ziyu Liu Rong Zhang Wenya Qiang Xudong Zhang Minggang Xia | 2024 | Nano Research2024，17，4： | 0 |
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