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| 1 | Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection显示文摘AIM: To assess blood chitinase 3-like 1(CHi3L1) levels for 2 mo after minimally invasive colorectal resection(MICR) for colorectal cancer(CRC). METHODS: CRC patients in an Institutional Review Board approved data/plasma bank who underwent elective MICR for whom preoperative(PreO p), early postoperative(PostO p), and 1 or more late PostO p samples [postoperative day(POD) 7-27] available were included. Plasma CHi3L1 levels(ng/m L) were determined in duplicate by enzyme linked immunosorbent assay. RESULTS: PreOp and PostOp plasma sample were available for 80 MICR cancer patients for the study. The median PreOp CHi3L1 level was 56.8 CI: 41.9-78.6 ng/mL(n = 80). Significantly elevated(P < 0.001) median plasma levels(ng/mL) over PreOp levels were detected on POD1(667.7 CI: 495.7, 771.7; n = 79), POD 3(132.6 CI: 95.5, 173.7; n = 76), POD7-13(96.4 CI: 67.7, 136.9; n = 62), POD14-20(101.4 CI: 80.7, 287.4; n = 22), and POD 21-27(98.1 CI: 66.8, 137.4; n = 20, P = 0.001). No significant difference in plasma levels were noted on POD27-41. CONCLUSION: Plasma CHi3L1 levels were significantly elevated for one month after MICR. Persistently elevated plasma CHi3L1 may support the growth of residual tumor and metastasis. | HMC Shantha Kumara David Gaita Hiromichi Miyagaki Xiaohong Yan Sonali AC Hearth Linda Njoh Vesna Cekic Richard L Whelan | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 4 |
| 2 | Plasma MMP-2 and MMP-7 levels are elevated first month after surgery and may promote growth of residual metastases显示文摘BACKGROUND MMP-2 also known as gelatinase A and MMP-7(matrilysin)are members of the zinc-dependent family of MMPs(Matrix metalloproteinase).MMP-2 and MMP-7 are remodeling enzymes that digest extracellular matrix;MMP-2 is extensively expressed during development and is upregulated at sites of tissue damage,inflammation,and in stromal cells of metastatic tumors.MMP-7 is expressed in the epithelial cells and in a variety of cancers including colon tumors.Plasma MMP-2 and MMP-7 levels were assessed before and after minimally invasive colorectal resection for cancer pathology.AIM To determine plasma MMP-2 and MMP-7 levels before and after minimally invasive colorectal resection for cancer pathology.METHODS Patients enrolled in a plasma bank for whom plasma was available were eligible.Plasma obtained from preoperative(Preop)and postoperative blood samples was used.Only colorectal cancer(CRC)patients who underwent elective minimally invasive cancer resection with preop,post-operative day(POD)1,3 and at least 1 late postop sample(POD 7-34)were included.Late samples were bundled into 7 d blocks(POD 7-13,14-20,etc.)and treated as single time points.Plasma MMP-2 and MMP-7 levels were determined via enzyme-linked immunosorbent assay in duplicate.RESULTS Total 88 minimally invasive CRC resection CRC patients were studied(right colectomy,37%;sigmoid,24%;and LAR/AR 18%).Cancer stages were:1,31%;2,30%;3,34%;and 4,5%.Mean Preop MMP-2 plasma level(ng/mL)was 179.3±40.9(n=88).Elevated mean levels were noted on POD1(214.3±51.2,n=87,P<0.001),POD3(258.0±63.9,n=80,P<0.001),POD7-13(229.9±62.3,n=65,P<0.001),POD 14-20(234.9±47.5,n=25,P<0.001),POD 21-27(237.0±63.5,n=17,P<0.001,)and POD 28-34(255.4±59.7,n=15,P<0.001).Mean Preop MMP-7 level was 3.9±1.9(n=88).No significant differences were noted on POD 1 or 3,however,significantly elevated levels were noted on POD 7-13(5.7±2.5,n=65,P<0.001),POD 14-20(5.9±2.5,n=25,P<0.001),POD 21-27(6.1±3.6,n=17,P=0.002)and on POD 28-34(6.8±3.3,n=15 P<0.001,)vs preop levels.CONCLUSION MMP-2 levels are elevated for 5 wk and MMP-7 levels elevated for weeks 2-6.The etiology of these changes in unclear,trauma and wound healing likely play a role.These changes may promote residual tumor growth and metastasis. | HMC Shantha Kumara Hiromichi Miyagaki Sajith A Herath Erica Pettke Xiaohong Yan Vesna Cekic Richard L Whelan | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 3 |
| 3 | NEJM:埃博拉病毒可在康复者精液与眼睛中存活长达6个月显示文摘一个国际研究小组最新发现,埃博拉病毒不仅可在康复者精液里长时间存活,还能在康复者的眼睛里存活。研究人员说,这一发现凸显了对康复者进行眼部检查的必要性。 | Varkey JB Shantha JG Crozier I | 2015 | 疾病监测2015，30，5： | 2 |
| 4 | CD4 count is predictive of outcome in HIV-positive patients undergoing abdominal operations显示文摘 | Deneve JL Shantha JG Page AJ | 2010 | Am J Surg2010，200，6： | 1 |
| 5 | A new method for measurement of sinoatrial conduction time显示文摘 | Narula O S Shantha N Vasquez I | 1978 | Circulation1978，58，4： | 1 |
| 6 | Azo polymeric hydrogels for colon targeted drug delivery显示文摘 | Shantha KL Ravichandran P Rao PK | 1995 | Biomaterials1995，16，17： | 1 |
| 7 | Behaviour of Aspergillus flavus in presence oF Aspergillus niger during biosynthesis o4 aflatoxin B1 显示文摘 | Shantha T Rati ER Shankar TNB | 1990 | Antonie van Leeuwenhoek1990，58，2： | 1 |
| 8 | CD4 count is predictive of outcome in HIV-positive patients undergoing abdominal opera- tions显示文摘 | Deneve JL Shantha JG Page AJ | 2010 | Am J Surg2010，200，6： | 1 |
| 9 | Comparative outcomes of manual small incision cataract surgeryand phacoemulsification performed by ophthalmology traineesin a tertiary eye care hospital in India;a retrospective cohort de-sign显示文摘 | Khanna RC Kaza S Palamaner Subash Shantha G Sangwan VS | 2012 | BMJ Open2012，2，5： | 1 |
| 10 | Synthesis,characterization, and utilization of methacrylic esers of polyhydric alcohols显示文摘 | SHANTHA K L KRISHNAMURTI N | 1989 | J Appl Polym Sci1989，37，： | 1 |
| 11 | Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein:a cross-sectional study from south India显示文摘 | SHANTHA G P KUMAR A A JEYACHANDRAN V | 2009 | Thyroid Res2009，2，1： | 1 |
| 12 | Sero diagnosis of tuberculosis in children using two ELISA kits显示文摘 | Swaminathan S Umadevi P Shantha S | 1999 | Indian J Pediatr1999，66，6： | 1 |
| 13 | Myocardial infarction intreatment hypertensive patients显示文摘 | Michael HA Hillel WC Shantha M | 2000 | Circulation2000，101，10： | 1 |
| 14 | Plasma soluble vascular adhesion molecule-1 levels are persistently elevated during the first month after colorectal cancer resection显示文摘 | H. Shantha Kumara Samer Tohme Sonali Herath Xiaohong Yan Anthony Senagore Abu Nasar Matthew Kalady Raymond Baxter Richard Whelan | 2012 | Surgical Endoscopy2012，，6： | 1 |
| 15 | Synthesis and characterization of chemically modified chitosan microspheres显示文摘 | Shantha KL Harding DRK | 2002 | Carbohydr Polym2002，48，： | 1 |
| 16 | Plasma from the second and third weeks after open colorectal resection for cancer stimulates in vitro endothelial cell growth, migration, and invasion显示文摘 | H. M. C. Shantha Kumara Daniel Kirchoff Samer Naffouje Michael Grieco Sonali A. C. Herath Nadav Dujovny Matthew F. Kalady Neil Hyman Linda Njoh Richard L. Whelan | 2012 | Surgical Endoscopy2012，，3： | 1 |
| 17 | Assoeiation between glycosylated hemoglobin and intentional weight loss in overweight and obese patients with type 2 diabetes melli- tus:a retrospective cohort study 显示文摘 | Shantha GP Kumar AA Kahan S | 2012 | Diabetes Edue2012，38，3： | 1 |
| 18 | Estimation of attitudes from a low-cost miniaturized inertial platform using Kalman Filter-based sensor fusion algorithm显示文摘 | N. Shantha Kumar T. Jann | 2004 | Sadhana2004，，2： | 1 |
| 19 | Laparoscopic cholecystectomy:anesthesia-related complications and guidelines显示文摘 | Shantha TR Harden J | 1991 | Surg Laparosc Endosc1991，1，3： | 1 |
| 20 | Preparation,swelling characteristics and evaluation ofhydrogels for stomach specific drug delivery显示文摘 | RAVICHANDRAN P SHANTHA K L RAO K P | 1997 | Int JPharm1997，154，1： | 1 |
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