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| 1 | AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function显示文摘LSD1 (在新名称下面的 KDM1 ) 是属于黄素依赖者胺 oxidase 家庭的首先识别的离氨酸特定的 histone demethylase。这里,我们报导那 AOF1 (在新名称下面的 KDM1B ) ,与 LSD1 有关的哺乳动物的蛋白质,也为 H3K4me1 和 H3K4me2 与特性拥有 histone demethylase 活动。象 LSD1 一样,高度保存的 SWIRM 领域为它的酶的活动被要求。然而, AOF1 在几个方面不同于 LSD1。首先, AOF1 不看起来形成包含 histone deacetylases 的稳定的蛋白质建筑群。第二, AOF1 被发现在房间周期的有丝分裂的阶段期间本地化到染色体,而 LSD1 不做。第三, AOF1 镇压抄写什么时候拴住到 DNA 和这项压抑活动,独立于它的 demethylase 活动。结构、功能的分析为 demethylase 作为必要识别了它的唯一的 N 终端 Zf-CW 领域活动无关的压抑功能。一起,我们的学习在黄素依赖者胺 oxidases 的家庭作为第二 histone demethylase 识别 AOF1 并且揭示 AOF1 的 demethylase 独立的压抑功能。 | Ze Yang Jun Jiang David M Stewart Shankang Qi Kenichi Yamane Jiwen Li Yi Zhang Jiemin Wong | 2010 | Cell Research2010，20，3： | 6 |
| 2 | Comparative glycemic control, safety and patient ratings for a new 4?mm? × ?32G insulin pen needle in adults with diabetes显示文摘 | Laurence J. Hirsch Michael A. Gibney John Albanese Shankang Qu Kenneth Kassler-Taub Leslie J. Klaff Timothy S. Bailey | 2010 | Current Medical Research & Opinion2010，，6： | 2 |
| 3 | Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway显示文摘短链的丰满的酸和他们的相应 acyl-CoAs 在新陈代谢的小径的十字路口坐并且在多样的细胞的过程起重要作用。他们也是为蛋白质 translational 以后离氨酸 acylation 修正的先锋。一个引人注目的例子是最新识别的离氨酸 2-hydroxyisobutyrylation (K 从 2-hydroxyisobutyrate 和 2-hydroxyisobutyryl-CoA 被导出的 hib ) 。Histone K hib 被显示了在 spermatogenic 房间与活跃基因表示被联系。然而,调整这条 translational 以后离氨酸 acylation 小径的关键元素仍然保持未知。这妨碍了这修正由施加它的生物功能的机制的描述。这里,我们在开始发育的酵母显示出那 Esa1p,它在人的相当或相同事物 Tip60 能增加 K hib 到在 vitro 并且在 vivo 的底层蛋白质。另外,我们作为主要的酶识别了 HDAC2 和 HDAC3 移开 K hib 。而且,我们报导第一 K 在哺乳动物的房间的 hib proteome,识别 6 548 K 1 725 底层蛋白质上的 hib 地点。我们的学习因此为 histone K hib 标记,和主要 K hib 蛋白质底层。这些结果不仅说明这条新离氨酸 acylation 小径的风景,而且为学习与这条小径联系的细胞的代谢物的多样的功能打开新大街。 | He Huang Zhouqing Luo Shankang Qi Jing Huang Peng Xu Xiuxuan Wang Li Gao Fangyi Li Jian Wang Wenhui Zhao Wei Gu Zhucheng Chen Lunzhi Dai Junbiao Dai Yingming Zhao | 2018 | Cell Research2018，28，1： | 2 |
| 4 | Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOFI/KDMlb显示文摘 | Qi Zhang Shankang Qi Mingchu Xu Lin Yu Ye Tao Zengqin Deng Wei Wu Jiwen Li Zhongzhou Chen Jiemin Wong | 2013 | Cell Research2013，23，2： | 2 |
| 5 | CokmparativegIycemin con- trol, safety and patient ratings for a new 4mm× 32G insulin pen needle in- adults with diabetes显示文摘 | Hirsch LJ Gibney MA Shankang Qu JA | 2010 | Current Medi- cal Research & Opinion2010，26，6： | 1 |
| 6 | Effect of PEG content in soft segment on the crystallization of cast film of waterborne polyurethane 显示文摘 | ZHOU SHANKANG(周善康) XU YIHAO(许一好) ZHUANG ZHIQIANG(庄志强) | 2000 | Xiamen University : Natural Science Edition2000，39，3： | 1 |
| 7 | Indoor Air Pollution and Pulmonary Function in Children显示文摘Pulmonary function in winter time in 1,343 school children aged 10-13 years was measured in four cities locatd in northern and southern part of China.The results showed that FVC,FEV1,PEF,V75,V50and V25 in children living in homes with coal stoves were decreased by 1.5-10.7% compared with children linving in homes with gas or LPG stoves in Chengde and Shanghai.In contrast to this,no significant difference in pulmonary function was found in Shenyang and Wuhan,It suggested that this phenomenon was related to indoor air pollution,and partly related to passive smoking or outdoor air pollution. | SHEN SHANKANG, QIN YUHUI, CAO ZHAOJING, SHANG JIANYING, LIUYUNGQING, YANG XU, DENG YONGQING, HUANG JIANG, FUZHENYING, AND SONG XIANGDONGInstitute of Prevention and Treatment for Occupational Disease, Hubei Institute ofEnvironmental Health Monitoring, Chinese Academy of Preventive Medicine, Beijing Chengde Municipal Sanitation and Anti-epidemic Station, Hebei ShenyangMunicipal Sanitation and Anti-epidemic Station, Liaoning ' WuhanMunicipal Sanitation and Anti-epidemic Station, Hubei ShanghaiMunicipal Sanitation and Anti-epidemic Station, Shanghai, China | 1992 | Biomedical and Environmental Sciences1992，5，2： | 0 |
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