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238篇 您的检索式:作者名="Shakya"
    题名 作者 年代 出处 被引量
1CT平扫预测高血压脑出血早期血肿扩大的价值显示文摘目的探讨CT平扫征象预测高血压脑出血(ICH)患者血肿扩大的价值。方法入组80例发病6 h以内的ICH患者,入院行头颅CT扫描,由两位影像科医师评估血肿内“黑洞征”和“卫星征”。根据24 h CT复查结果,分为血肿扩大组和血肿未扩大组。ROC曲线比较“黑洞征”、“卫星征”及其联合征象对血肿扩大的预测能力。结果“黑洞征”、“卫星征”和联合征象在血肿扩大组与血肿未扩大组之间差异有统计学意义(P均<0.05)。联合征象预测早期血肿扩大的敏感性、特异性、阳性预测值、阴性预测值及准确性分别为84.09%、63.89%、74.00%、76.67%和75.30%,其预测的准确性高于“黑洞征”(66.00%)和“卫星征”(69.70%)。结论头颅CT平扫联合征象较单一征象更能预测早期血肿扩大。傅璠 Shakya Milind Ratna 於帆 张苗 孙胜军 卢洁 2020医学影像学杂志2020,30,11:11
2天疱疮患者206例皮损分泌物病原学及药敏结果分析显示文摘目的分析天疱疮患者糜烂面皮损的病原菌组成及药敏情况,为临床早期合理选用抗生素提供依据。方法对本科2004年1月-2011年12月收治的206例天疱疮患者皮损分泌物细菌培养和药敏结果进行回顾性分析。结果分离出细菌200株中,金黄色葡萄球菌107株,耐甲氧西林金黄色葡萄球菌11株;50%以上金黄色葡萄球菌对青霉素、红霉素、克林霉素耐药,100%对万古霉素敏感,80%以上对利福平、复方新诺明敏感;29例多部位取材共检出病原菌53株。结论天疱疮糜烂面细菌主要由金黄色葡萄球菌构成,多数对青霉素、红霉素及克林霉素耐药,对万古霉素、利福平和复方新诺明敏感;病程长且多次就诊者易感染耐甲氧西林金黄色葡萄球菌;抗生素早期使用可参考皮损主要累及部位及该部位常见定植菌种类选择。郭生红 王琳 李明辉 Sanjaya Shakya 杨延华 张然 康梅 李薇 2012中国皮肤性病学杂志2012,26,11:9
3氨甲环酸在全髋关节置换术中的应用进展显示文摘目的:通过回顾既往公开发表的研究所提供的证据,对全髋关节置换术中使用氨甲环酸来减少出血量的有效性及安全性进行评估,同时对氨甲环酸的最佳剂量及给药方式进行探讨。方法:以'Tranexamic acid;Total hip arthroplasty;Blood loss;Method of administration;Venous thromboembolism'为检索词,对Pub Med,Medline,Cochrane,Ovid,Science Direct数据库进行检索,纳入标准:(1)英文文献;(2)患者为成年患者;(3)文章主题为氨甲环酸在全髋关节置换术中的应用。排除标准:(1)关于其他关节置换手术的研究;(2)关于根治性矫形手术的研究。结果:(1)使用氨甲环酸可减少全髋关节置换术术后的出血;(2)通过与安慰剂组或对照组进行比较可以发现氨甲环酸组患者深静脉血栓形成的发病率低于安慰剂或对照组;(3)氨甲环酸的给药途径包括静脉给药(最常见),局部给药和口服给药(最少见);(4)对于不同的给药途径,给药时间导致给药剂量也存在很大分歧。结论:氨甲环酸应用于全髋关节置换术,可以降低术中和术后失血量,尤其是术后失血量,进而降低临床输血量,降低因失血和输血导致的感染等并发症和副反应发生的风险。同时,氨甲环酸安全性良好,并不会额外增加静脉血栓栓塞发生的风险。但是,现有研究在给药途径和使用剂量等方面仍存在很大分歧,因此,未来的工作重点应集中于如何就氨甲环酸在全髋关节置换术中的使用时间、给药途径和使用剂量等方面进行优化,取得共识。Raskin Shakya 亓一鸣 芮云峰 陈辉 2018东南大学学报(医学版)2018,37,1:8
4锁骨钩钢板联合缝合锚钉重建喙锁韧带治疗不稳定锁骨远端骨折显示文摘目的探讨锁骨钩钢板联合缝合锚钉重建喙锁韧带治疗NeerⅡ型或Ⅴ型锁骨远端骨折的疗效。方法 2010年1月—2016年6月使用锁骨钩钢板联合缝合锚钉重建喙锁韧带治疗16例NeerⅡ型或Ⅴ型锁骨远端骨折患者。其中男12例,女4例;年龄14~81岁,平均45.6岁。致伤原因:摔伤10例,交通事故伤2例,高处坠落伤2例,重物砸伤2例。锁骨骨折Neer分型:Ⅱa型2例,Ⅱb型13例,Ⅴ型1例。损伤严重程度评分(ISS)为6~29分,平均11.2分。受伤至手术时间为1~18 d,平均6.4 d。记录患者手术时间、术中出血量、住院时间、骨折愈合情况和术后并发症;末次随访时采用上肢功能评定表(DASH)评分、肩关节Constant评分和牛津肩关节评分(OSS)评价肩关节功能。结果所有手术均顺利完成,手术时间50~100 min,平均75.6 min;术中出血量30~100 mL,平均52.8 mL;住院时间4~47 d,平均13.7 d。所有患者均获随访,随访时间1.2~7.5年,平均3.5年。锁骨骨折均愈合,愈合时间9.4~13.6周,平均11.9周。无骨折不愈合、骨折移位、内固定失效、切口感染等并发症发生。15例患者于骨折愈合和功能恢复后取出锁骨钩钢板,1例因无明显不适拒绝二次手术取出锁骨钩钢板。末次随访时,DASH评分为0~13分,平均2.2分;肩关节Constant评分为90~100分,平均96.8分;OSS评分为12~14分,平均12.3分。结论锁骨钩钢板联合缝合锚钉重建喙锁韧带治疗NeerⅡ型或Ⅴ型锁骨远端骨折可获得较好临床疗效,术后并发症少,是一种治疗不稳定锁骨远端骨折的良好方法。吴双 陈家磊 张洁 Sujan Shakya 邢飞 项舟 2021中国修复重建外科杂志2021,35,8:6
5种植盾构术的研究进展显示文摘上前牙美学区在拔牙或即刻种植后,唇侧骨板因拔牙创伤或者血运降低,常发生唇侧牙槽骨的吸收塌陷,从而极大的影响前牙区的美学效果,甚至造成种植体的失败。为了避免唇侧软硬组织的吸收,获得更好的美学效果,近年来有学者提出了'盾构术'的概念,即在即刻种植手术中通过保留唇侧健康牙根片来保留牙周膜,从而避免唇侧骨板因为血运的减少而发生吸收。本文回顾了盾构术的相关文章,能帮助口腔临床医生更加全面的理解该技术。Supriya Shakya 张鑫 王剑 2020国际口腔医学杂志2020,47,1:5
6Optimization by Estimation of Distribution with DEUM Framework Based on Markov Random Fields显示文摘这篇论文论述一个 Markov 随机的领域(MRF ) 估计和采样的途径在答案的人口的概率分发。途径被用来用 Markov 随机的领域(DEUM ) 在一般标题分发评价下面定义算法的一个班。因为一张未受指导的图和一个解决方案的联合概率作为分发从图的结构导出的吉布斯是 factorized, DEUM 是在解决方案变量之间的相互作用被代表的分发算法(EDA ) 的评价的一个子类。这篇论文的焦点将在描述 DEUM 框架的三个主要特征上,它把它与传统的 EDA 区分开来。他们是:1 ) MRF 模型,的使用 2 ) 估计模型的参数的健康建模途径并且 3 ) 从模型的采样的蒙特卡罗途径。分发算法的关键词评价 - 进化 algorthms - 健康建模 - Markov 随机的地 - 吉布斯分发 Siddhartha K。Shakya 从 Vladimir 州立大学在计算机工程收到了他的 B.E 和 M.E 度。俄国,在 1998 和 1999 分别地,并且 M.Sc。在来自萨西克斯郡的大学的聪明的系统的度。在 2002 的英国。他从罗伯特·格登大学在计算机科学收到了他的博士学位,阿伯丁,在 2006 的英国。当前,他是在在 BT 研究以内的聪明的系统研究中心的一个研究家伙。Ipswich,英国。在加入 BT 以前,他是在罗伯特·格登大学的计算的学校里的一个研究助手。特别地,他的研究兴趣包括优化算法的理论、实际的方面分发算法,概率的图形的模型和 Markov 随机领域,绘画图的算法,机器学习技术,生物信息学和运作的研究的进化算法和评价技术,例如收入管理和动态定价。他在计算智力是 IEEE 和 ACM 协会的一个成员。约翰·麦卡尔在阿伯丁的大学学习了纯数学,在他在 1991 在谎言组的稳定的 Homotopy 上完成了一个博士的地方。从那以后,他的研究兴趣通过当模特儿和优化到进化算法并且最近地演变, EDA 的强壮的焦点。他特别地对 Markov 随机的领域模型和他们的潜力感兴趣由从评估答案的样品为健康建模改进启发式的搜索。他也在进化算法的应用有强烈、忍受的兴趣到医疗优化,特别地癌症化疗,并且在这个区域广泛地出版了。另外的兴趣包括粒子群,蚂蚁殖民地和人工的免疫系统。McCall 当前是在在他领导计算智力研究组的罗伯特·格登大学的计算的一个高级讲师。Siddhartha Shakya John McCall 2007International Journal of Automation and computing2007,4,3:5
7线状IgA大疱性皮病15例分析显示文摘目的分析线状IgA大疱性皮病的临床特点、治疗及预后,提高临床医生对本病的认识。方法回顾性分析本科2004年1月-2011年12月诊治的15例线状IgA大疱性皮病的临床资料。结果男6例,女9例;儿童型5例,成人型10例;皮损初始部位:面部4例,口腔黏膜及双下肢各3例;累及躯干和四肢12例,14例临床表现为红斑或正常皮肤上出现水疱,6例水疱呈环形或半环形排列。皮损组织病理均见表皮及复层鳞状上皮下水疱或裂隙,直接免疫荧光均表现为基底膜带线状IgA沉积。13例予糖皮质激素治疗,皮损均控制;2例予氨苯砜治疗,均发生不良反应。结论线状IgA大疱性皮病的皮损以口腔黏膜、面部及下肢首发居多,好发于躯干和四肢,临床表现为红斑或正常皮肤上出现水疱,呈孤立、环形和/或半环形排列;组织病理可见表皮或复层鳞状上皮下水疱或裂隙,直接免疫荧光示基底膜带线状IgA沉积是诊断的主要依据。治疗上可选用氨苯砜、糖皮质激素和磺胺类药物等。郭生红 Sanjaya Shakya 李薇 王琳 杜晓萍 2012中国皮肤性病学杂志2012,26,10:4
8Effects of seismic surge waves and implications for moraine-dammed lake outburst显示文摘冰碛水坝通常由于在建水坝的湖,和巨浪波浪由巨浪波浪高出崩溃被地震很可能引起。地震的水波浪(SWW ) 是引起水坝在地震地区碎的一个主要因素。模型实验在各种各样的水深度,震波,和山峰的条件下面与一辆摇晃的水坦克集中于 SWW 的这份报纸扎根了加速。二个实验方程为分别地为低、高的频率估计最大的波浪高度被获得。最后,我们在场在西藏的 Midui 冰河湖上的实验方程的申请高原。Cui DU Lingkan YAO Yidan HUANG Jiahong YAN Subhashsagar SHAKYA 2016Frontiers of Earth Science2016,10,3:4
9慢性家族性良性天疱疮16例临床与病理分析显示文摘目的探讨慢性家族性良性天疱疮(CFBP)的临床、病理学特点,以提高对本病的认识。方法分析经病理学确诊的16例CFBP的临床资料、组织病理及治疗。结果男10例,女6例,平均年龄37.8岁,平均病程10.56年,发病年龄3~52岁;7例有家族史。皮损好发于腹股沟、腋窝、肛周,泛发者1例;表现为在红斑/外观正常皮肤上出现水疱或丘疹伴糜烂渗液,呈扁平柔软、湿润增殖面;1例合并银屑病。组织病理学检查16例均见棘层松解如倒塌砖墙样,11例伴角化过度、松解上方灶性角化不全,13例见角化不良细胞,9例角质层/棘层上部见圆体,5例见谷粒,12例见棘层松解边缘棘层肥厚及表皮突延长;直接免疫荧光检查均阴性。口服小剂量强的松等治疗约2周可以改善临床症状,但易反复。结论本病病程长,43.75%有阳性家族史,临床易误诊为湿疹或增殖型天疱疮,组织病理学检查发现倒塌砖墙样棘层松解及直接免疫荧光检查为阴性有诊断及鉴别诊断价值,但缺乏有效治疗。郭生红 李薇 Sanjaya Shakya 王琳 杜晓萍 2012中国皮肤性病学杂志2012,26,8:3
10Optimization of taste-masking on ibuprofen microspheres with selected structure features显示文摘The microsphere was a primary particulate system for taste-masking with unique structural features defined by production process. In this article, ibuprofen lipid microspheres of octadecanol and glycerin monostearate were prepared to mask the undesirable taste of ibuprofen via three kinds of spray congealing processes, namely, air-cooling, water-cooling and citric acid solution-cooling. The stereoscopic and internal structures of ibuprofen microspheres were quantitatively analyzed by synchrotron radiation X-ray micro-computed tomography(SR-μCT) to establish the relationship between the preparation process and microsphere architectures. It was found that the microstructure and morphology of the microspheres were significantly influenced by preparation processes as the primary factors to determine the release profiles and taste-masking effects. The sphericity of ibuprofen microspheres congealed in citric acid solution was higher than that of other two and its morphology was more regular than that being congealed in air or distilled water, and the contact angles between congealing media and melted ibuprofen in octadecanol and glycerin monostearate well demonstrated the structure differences among microspheres of three processes which controlled the release characteristics of the microspheres. The structure parameters like porosity, sphericity, and radius ratio from quantitative analysis were correlated well with drug release behaviors. The results demonstrated that the exterior morphology and internal structure of microspheres had considerable influences on the drug release behaviors as well as taste-masking effects.Wei Qin Yuanzhi He Zhen Guo Liu Zhang Li Wu Xianzhen Yin Shailendra Shakya Abi Maharjan Yan Tang Weifeng Zhu Jiwen Zhang 2019Asian Journal of Pharmaceutical Sciences2019,14,2:3
11Damming of Large River by Debris Flow: Dynamic Process and Particle Composition显示文摘The frequency and extent of debris flows have increased tremendously due to the extreme weather and the Wenchuan earthquake on May 12, 2008. Previous studies focused on the debris flow from gullies damming the mountain streams. In this paper, an equation for the run-out distance of debris flow in the main river is proposed based on the dynamic equation of debris flow at different slopes given by Takahashi. By undertaking field investigations and flume experiments, a new calculation method of the volume of debris flow damming large river is obtained. Using the percolation theory and the renormalization group theory it was deduced that the large particles should comprise more than 50% for forming a stable debris flow dam. Hence, the criteria of damming large river by debris flow is presented in terms of run-out distance and grain composition which was then validated through the event of damming river by debris flow at Gaojia gully, the upper reaches of the Minjiang River, Sichuan, China, on July 3, 2011.DU Cui YAO Ling-kan SHAKYA Subhashsagar LI Lun-gui SUN Xiao-dan 2014Journal of Mountain Science2014,11,3:3
12疱疹样皮炎1例显示文摘1病历摘要 患者男,71岁。全身反复红斑、丘疹、水疱伴剧烈瘙痒10个月。10个月前患者无明显诱因双胫前出现弥漫绿豆至蚕豆大、形状不规则边缘模糊的红斑。部分红斑上密集针尖大丘疹.散在芝麻至绿豆大孤立厚壁张力性清亮水疱,不易破溃,郭生红 Sanjaya Shakya 贾玲 闫薇 李薇 2013临床皮肤科杂志2013,42,9:3
13纵隔精原细胞瘤的CT诊断显示文摘目的:探讨纵隔精原细胞瘤的CT诊断价值。方法:结合文献,回顾性分析经病理证实的纵隔精原细胞瘤1例的CT表现。结果:纵隔精原细胞瘤的CT表现为前上纵隔形态不规则实性肿块,可明显强化。结论:纵隔实性肿瘤难以定性时,应考虑到精原细胞瘤的可能性。Boblin Raj Shakya 毛椿平 骆静 黄满华 黄劲柏 2015长江大学学报(自科版)(下旬)2015,12,4:2
14姜黄素对心肌梗死大鼠心肌ROS、MDA及P-AKT/AKT的影响显示文摘目的研究姜黄素对心肌梗死大鼠心肌ROS、MDA与P-AKT/AKT的表达情况。方法选60只成年雄性SD大鼠,随机分为对照组(control,n=15)、手术组(MI,n=15),溶剂组(solvent,n=15)和药物组(curcumin,n=15)。对照组在左冠状动脉前降支处穿线,打一假结。手术组、溶剂组和药物组都结扎左冠状动脉前降支,阻断其血流通过。24 h以后将三组进行不同干预,手术组不进行任何干预,溶剂组腹腔注射溶剂(乙醇和聚乙二醇的混合物),药物组腹腔注射姜黄素100 mg/kg。28 d后取出大鼠心脏,检测大鼠心肌的ROS、MDA表达含量。采用Western blot方法检测大鼠心肌组织中P-AKT/AKT的表达情况。结果心电图结果显示,手术组手术后ST变移率与T波幅度明显高于手术前(P<0.01),对照组手术前后心电图没有明显区别(P>0.05)。手术组与溶剂组大鼠心肌中ROS、MDA明显高于药物组(P<0.01),手术组与溶剂组没有明显差别(P>0.05),手术组与溶剂组大鼠心肌中ROS、MDA明显高于对照组(P<0.01)。Western blot检测P-AKT/AKT表达结果显示,手术组和溶剂组心肌梗死大鼠心肌内P-AKT/AKT表达情况明显低于药物组(P<0.05);手术组与溶剂组没有明显差别(P>0.05),手术组与溶剂组与对照组比P-AKT/AKT表达情况明显降低(P<0.05)。结论姜黄素能明显降低大鼠心肌梗死心肌内ROS、MDA的表达量;增高大鼠心肌梗死心肌内P-AKT/AKT表达。刘聪辉 贺兆发 李奕红 刘春辉 张丽 卢均坤 Sheelendra Shakya 2015中华临床医师杂志(电子版)2015,9,7:2
15Multi-dimensional visualization for the morphology of lubricant stearic acid particles and their distribution in tablets显示文摘The shapes of particles and their distribution in tablets, controlled by pretreatment and tableting process, determine the pharmaceutical performance of excipient like lubricant. This study aims to provide deeper insights to the relationship of the morphology and spatial distribution of stearic acid(SA) with the lubrication efficiency, as well as the resulting tablet property. Unmodified SA particles as flat sheet-like particles were firstly reprocessed by emulsification in hot water to obtain the reprocessed SA particles with spherical morphology. The three-dimensional(3 D) information of SA particles in tablets was detected by a quantitative and non-invasive 3 D structure elucidation technique, namely, synchrotron radiation X-ray micro-computed tomography(SR-μCT). SA particles in glipizide tablets prepared by using unmodified SA(GUT), reprocessed SA(GRT), as well as reference listed drug(RLD) of glipizide tablets were analyzed by SR-μCT. The results showed that the reprocessed SA with better flowability contributed to similarity of breaking forces between that of GRT and RLD. SA particles in GRT were very similar to those in RLD with uniform morphology and particle size, while SA particles in GUT were not evenly distributed. These findings not only demonstrated the feasibility of SR-μCT as a new method in revealing the morphology and spatial distribution of excipient in drug delivery system, but also deepened insights of solid dosage form design into a new scale by powder engineering.Liu Zhang Shailendra Shakya Li Wu Jiangtao Wang Guanghui Jin Huimin Sun Xianzhen Yin Lixin Sun Jiwen Zhang 2020Asian Journal of Pharmaceutical Sciences2020,15,1:2
16成人传染性单核细胞增多症1例显示文摘患者男,30岁。面、项部红斑、丘疹伴瘙痒15d,泛发全身13d。体检:T37.4℃,全身浅表淋巴结肿大,咽充血,咽腭弓瘀点,双侧扁桃体I°肿大。皮肤科情况:头部散在分布红斑;项部密集分布丘疹、斑丘疹,融合成斑块;颈部、躯干、四肢丘疹及暗红斑,双小腿伸侧散在紫癜;掌、跖部暗红斑,肿胀明显,轻触痛。外周血异形淋巴细胞8%,血生化示肝酶升高,EB病毒抗体阳性,彩色多普勒检查示脾大。诊断:成人传染性单核细胞增多症。经地塞米松等治疗,患者痊愈。郭生红 杨延华 Sanjaya Shakya 王婷婷 李薇 2012中国皮肤性病学杂志2012,26,12:2
17Key points in surgical management of mandibular condylar fractures显示文摘Mandibular condylar fractures are among the most common facial fractures and some of the most difficult to manage.Opinions about the management of mandibular condylar fractures differ among surgeons.With the implementation of new technology,an increased understanding of fracture man-agement,and better functional and morphological outcomes reported in the literature,open reduction and internal fixation is becoming many surgeons preferred choice for the treatment of condylar fractures.Because surgical treatment of such fractures is complex,certain factors must be considered to achieve satisfactory outcomes.In this article,we summarise six key points in the management of mandibular condylar fractures:virtual evaluation of condylar fracture,a suitable surgical approach,good reduction,stable internal fixation,repair of the articular disc,and restoration of the mandibular arch width.We believe that these points will help to improve the prognosis of mandibular condyle fractures.Shubhechha Shakya Xiao Zhang Lei Liu 2020Chinese Journal of Traumatology2020,23,2:2
18Impact of land cover change on a mountain ecosystem and its services:case study from the Phobjikha valley,Bhutan显示文摘Introduction:Mountains occupy 24%of the global land surface and are home to 12%of the world’s population;they host the world’s principal biomes and supply a diverse array of ecosystem services.But they are also highly sensitive to both natural and human induced changes,which can affect service provision meant for one third of humanity.Systematic research on impacts of land cover change from mountains at the local scale are limited,especially in developing countries,which poses a barrier to informed planning for sustainable management.Bhutan being in the forefront as contributor towards global conservation goals,a case study following a systematic research framework considering quantitative,qualitative and geospatial tools was experimented.Outcome:Respondents identified and ranked 24 ecosystem services,among which the provisioning services were the most important,followed by cultural,regulating,and supporting services.Forest was the most important land cover type for services,followed by marsh,scrub,water bodies,and agriculture.The area of forest declined by 2%and marsh by 7%over the 32-year period,suggesting a potential decrease in ecosystem services,which was also observed by the local community.Discussion:It was observed that 80%of the local people are still directly dependent on the diverse ecosystems for services.Though subtle,the decrease in land cover has implications for livelihoods of the people and the rich biodiversity of the area.Aspiring communities for local development needs guidance for identifying trade-offs in land cover types in sustainable management.An integrated and holistic approach focusing on both conservation and community development should be used to manage and develop the valley and the region sustainably.Conclusion:We recommend diversifying the limited livelihood strategies(potato farming and livestock grazing)to reduce the potential vulnerability of the local community and reduce the pressure on forest and marsh.Proper land use planning in the valley would be beneficial to maintain and regulate land uses in an effective way and avoid possible conflicts between settlement,agriculture,forest,and marsh.Sunita Chaudhary Dago Tshering Tshering Phuntsho Kabir Uddin Bandana Shakya Nakul Chettri 2017Ecosystem Health and Sustainability2017,3,9:2
19表现为环形红斑水疱的疱疹样皮炎1例显示文摘患者女,46岁。全身反复红斑、水疱伴痒6年,加重20d。皮损组织病理示:表皮下水疱,其内中性粒细胞聚集成小脓肿,真皮内散在淋巴细胞浸润。皮损边缘组织直接免疫荧光示:真皮乳头浅层纤维素样IgA,IgM,C3沉积。诊断:疱疹样皮炎。予糖皮质激素、四环素等治疗好转出院。随访3年无复发,目前仍在随访中。夏登梅 郭生红 Sanjaya Shakya 侯文婕 闫薇 李薇 2013中国皮肤性病学杂志2013,27,7:2
20Ritodrine and isoxsuprine in management of preterm labor显示文摘Yogol NS Shakya R Thapa P 2009JNMA J Nepal Med Assoc2009,48,176:1
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