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| 1 | Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients显示文摘AIM To investigate the clinical utility of serum annexin A2(ANXA2) as a diagnostic marker for early hepatocellular carcinoma(HCC).METHODS This study was performed in HCC Clinic of Ain Shams University Hospitals, Cairo, Egypt and included: Group 1: Fifty patients with early stage HCC(Barcelona Clinic Liver Cancer stage A); Group 2: Twenty five patients with chronic liver disease; and Control Group: Fifteen healthy, age-and sex-matched subjects who were seronegative for viral hepatitis markers. The followinglaboratory investigations were done: Viral hepatitis markers [hepatitis B surface antigen and hepatitis C virus(HCV) antibodies], HCV RNA in HCV antibody-positive patients, serum alpha fetoprotein(AFP), and serum ANXA2 levels.RESULTS In this study, 88% of HCC patients(n = 44) were HCVpositive, while HBV infection represented only 8% of all HCC patients(n = 4); and two patients were negative for both viral markers. A highly significant difference was found between patients with HCC and chronic liver disease as well as controls with regard to serum ANXA2 levels(130, IQR 15-240; 15, IQR 15-17; and 17, IQR 15-30 ng/m L, respectively). The area under the curve of ANXA2 was 0.865; the cut-off value was established to be 18 ng/mL with a diagnostic sensitivity of 74% and a specificity of 88%, while the sensitivity and specificity of AFP at the cut-off value of 200 ng/dL were 20% and 100%, respectively.CONCLUSION Serum ANXA2 may serve as a biomarker for the early detection of HCC. | Mohamed K Shaker Hanzada I Abdel Fattah Ghada S Sabbour Iman F Montasser Sara M Abdelhakam Eman El Hadidy Rehab Yousry Ahmed K El Dorry | 2017 | World Journal of Hepatology2017，9，9： | 4 |
| 2 | Electrostatic fabrication of ultrafine conducting fibers: polyaniline/polyetbylene oxide blends 显示文摘 | Norries I D Shaker M M Ko F K | 2000 | Synth Met2000，114，： | 1 |
| 3 | Momparler,preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza 2-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells显示文摘 | Shaker S Bernstein M Momparler L F | 2003 | Leuk Res2003，27，5： | 1 |
| 4 | Improvement of the interfacial adhesion between kevlar fiber and resin by using R- F plasma显示文摘 | SHAKER M KAMEL I KO F | 1996 | Journal of Materials Technology h-Research1996，18，4： | 1 |
| 5 | A Measure of Absorptive Capacity: Scale Development and Validation显示文摘 | Tessa C F Andreas E Shaker A Z | 2011 | European Management Journal2011，29，2： | 1 |
| 6 | Comparison of the low and high velocity impact response of Kevlar fiber-reinforced epoxycomposites显示文摘 | SHAKER M KO F SONG J | 1999 | Journal of Composites Technology : Research1999，21，4： | 1 |
| 7 | Durability of styrene-butadiene latex modified concrete显示文摘 | Ei-Dieb A S Reda M M | 1997 | Cement and Concrete Research1997，27，4： | 1 |
| 8 | Lyapunov stability for continuous-time multidimensional nonlinear systems 显示文摘 | Sharker H R Shaker F | 2014 | Nonlinear Dyn2014，75，4： | 1 |
| 9 | Primary nocturnal en- uresis :a new approach to conditioning treatment 显示文摘 | El - Anany F G Maghraby H A Shaker S E | 1999 | Urology1999，，02： | 1 |
| 10 | Electrostatic fabrication of ultrafine conducting fibers: polyaniline/polyethylene oxide blends 显示文摘 | Norris I D Shaker M M Ko F K et aI | 2000 | Synthetic Metals2000，114，： | 1 |
| 11 | Electrostatic fabrication of ultraiine conducting fibers: Polyaniline/polyethylene oxide blends 显示文摘 | Norris I D Shaker M M Ko F K | 2000 | Synthetic Metals2000，114，1： | 1 |
| 12 | Durability of styrene butadiene latex modified concrete 显示文摘 | Shaker F A Ei-Dieb A S Reda M M | 1997 | Cement and Concrete Research1997，27，5： | 1 |
| 13 | Salivary Micro-RNAs in Oral Cancer显示文摘 | Zahran F Ghalwash D Shaker O | 2015 | Oral Dis2015，21，6： | 1 |
| 14 | Improvement of interfacial adhesion between kevlar fiber and resin by using R-F plasma显示文摘 | SHAKER M KAMEL I KO F | 1996 | Journal of Composites Technology & Research1996，18，4： | 1 |
| 15 | Primary nocturnal enuresis:a new approach to conditioning treatment显示文摘 | Maghraby H A Shaker S E | 1999 | Urology1999，53，2： | 1 |
| 16 | The Early FeedingSkills Assessment for Preterm Fnfants显示文摘 | Thoyre S M Shaker C S Pridham K F | 2005 | Neonatal Netw2005，24，3： | 1 |
| 17 | Manufacturing parameters and quality characteristic of spray dried jameed 显示文摘 | Jumah R Y Tashtoush B Shaker R R Zrainy A F | 2000 | Drying Technology2000，，45： | 1 |
| 18 | The Antecedents and Consequences of Finn - level Entrepreneurship: The State of the Field显示文摘 | Zahra Shaker A Jennings Daniel F | 1999 | Entrepreneurship Theory and Practice1999，24，2： | 1 |
| 19 | Improvement of the Interfacial Adhesion between Kevlar Fiber and Resin by Using R-F Plasma显示文摘 | Shaker M Kamel I Ko F | 1996 | Journal of Composites Technology & Research1996，18，4： | 1 |
| 20 | Electrostatic fabrication of ultrafine conducting fibers: polyaniline/pelyethylene oxide blends 显示文摘 | Norris I D Shaker M M Ko F K | 2000 | Synth Met2000，114，： | 1 |
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