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| 1 | Ki-67 as a prognostic marker according to breast cancer molecular subtype显示文摘Objective: Ki-67 plays an important function in cell division, but its exact role is still unknown. Moreover, few works regarding its overall function were published. The present study evaluated the clinical significance of Ki-67 index as a prognostic marker and predictor of recurrence in different molecular subtypes of breast cancer. The relationship of Ki-67 index with different clinicopathological factors was also analyzed.Methods: Ki-67 index was measured in 107 cases of primary breast cancer from 2010-2012. These patients were evaluated for estrogen receptor, progesterone receptor, and HER2. Ki-67 was divided according to percentage levels: < 15% and > 15%. Followup ranged from 32 months up to 6 years.Results: Approximately 44, 23, 15, and 25 cases were grouped as luminal A, luminal B, HER2 subtype, and triple-negative(TN),respectively. No luminal A patients showed Ki-67 level higher than 15%, and their recurrence was 20%. In luminal B group, Ki-67 level higher than 15% was observed in 69% of patients, and recurrence was 39%. In HER2 subtype, Ki-67 was higher than 15% in34% of cases, and recurrence was 40%. In triple-negative cases, Ki-67 was higher than 15% in 60% of cases, and recurrence was detected in 32% of patients. Patients with Ki-67 less than 15% displayed better overall survival than those with Ki-67 higher than15%(P = 0.01). Patients with Ki-67 higher than 15% exhibited higher incidence of metastasis and recurrence than those with Ki-67 less than 15%(P = 0.000).Conclusions: Ki-67 may be considered as a valuable biomarker in breast cancer patients. | Nahed A.Soliman Shaimaa M.Yussif | 2016 | Cancer Biology & Medicine2016，13，4： | 16 |
| 2 | Real time endoscopic ultrasound elastography and strain ratio in the diagnosis of solid pancreatic lesions显示文摘AIM To evaluate the accuracy of the elastography score combined to the strain ratio in the diagnosis of solid pancreatic lesions(SPL). METHODS A total of 172 patients with SPL identified by endoscopic ultrasound were enrolled in the study to evaluate the efficacy of elastography and strain ratio in differentiating malignant from benign lesions. The semi quantitative score of elastography was represented by the strain ratio method. Two areas were selected, area(A) representing the region of interest and area(B) representing the normal area. Area(B) was then divided by area(A). Sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV), and accuracy were calculated by comparing diagnoses made by elastography, strain ratio and final diagnoses.RESULTS SPL were shown to be benign in 49 patients and malignant in 123 patients. Elastography alone had a sensitivity of 99%, a specificity of 63%, and an accuracy of 88%, a PPV of 87% and an NPV of 96%. The best cut-off level of strain ratio to obtain the maximal area under the curve was 7.8 with a sensitivity of 92%, specificity of 77%, PPV of 91%, NPV of 80% and an accuracy of 88%. Another estimated cut off strain ratio level of 3.8 had a higher sensitivity of 99% and NPV of 96%, but with less specificity, PPV and accuracy 53%, 84% and 86%, respectively. Adding both elastography to strain ratio resulted in a sensitivity of 98%, specificity of 77%, PPV of 91%, NPV of 95% and accuracy of 92% for the diagnosis of SPL. CONCLUSION Combining elastography to strain ratio increases the accuracy of the differentiation of benign from malignant SPL. | Hussein Okasha Shaimaa Elkholy Ramy El-Sayed Mohamed-Naguib Wifi Mohamed El-Nady Walid El-Nabawi Waleed A El-Dayem Mohamed I Radwan Ali Farag Yahya El-sherif Emad Al-Gemeie Ahmed Salman Mohamed El-Sherbiny Ahmed El-Mazny Reem E Mahdy | 2017 | World Journal of Gastroenterology2017，23，32： | 11 |
| 3 | 低温贮藏中华管鞭虾肌肉品质及组织蛋白酶H活性变化显示文摘为探究不同贮藏条件下中华管鞭虾组织蛋白酶H活性及肌肉品质的变化情况,以中华管鞭虾为对象,分别在冷藏(4℃,0~6 d)和冻藏(-18℃,0~120 d)条件下,比较分析完整虾组和去头虾组肌肉pH、持水力、硬度、弹性、肌原纤维蛋白含量、水分含量及各亚细胞分级中组织蛋白酶H活性等指标的变化。结果表明,随着贮藏时间的延长,整虾和去头虾肌肉pH均不断升高,但去头虾组pH升高幅度略低于完整虾组;虾肉中肌原纤维蛋白含量随贮藏时间延长而逐渐降低,完整虾组和去头虾组在冷藏至6 d时分别降低了38.32%和30.88%,在冻藏至120 d时分别减低了61.67%和52.09%;在整个冻藏过程中,两组虾的硬度和弹性均出现先上升后下降的趋势,而冷藏贮藏过程中则始终呈现下降趋势;组织蛋白酶H在不同亚细胞分级中活性变化不同,冻藏条件下两组虾组织蛋白酶H酶活整体低于冷藏条件下酶活,且完整虾组组织蛋白酶H活性整体高于去头虾组。综上,在低温贮藏过程中,相比于完整虾形式,以去头虾的贮藏方式更有利于对虾肌肉品质的保障,且组织蛋白酶H活性受贮藏温度影响较大。研究结果为不同贮藏方式下中华管鞭虾理化特性及组织蛋白酶活性变化提供了理论基础。 | 李志鹏 周晓娇 水珊珊 HATAB Shaimaa Reda Abd Elkhalik 张宾 | 2021 | 食品工业科技2021，42，22： | 10 |
| 4 | Effect of supplementing layer hen diet with phytogenic feed additives on laying performance, egg quality, egg lipid peroxidation and blood biochemical constituents显示文摘This study was conducted to evaluate the effects of supplementing laying hen diet with phytogenic additives on laying performance, egg quality, blood constituents and egg lipid peroxidation. Two hundred Lohmann Brown Lite laying hens were randomly allotted to 4 dietary treatments: control(without phytogenic additive), fennel seeds(5 g/kg), black cumin seeds(5 g/kg) and hot red pepper(5 g/kg).Each of the 4 diets was fed to 5 replicates of 10 hens for 8 weeks. No significant differences were observed in body weight or feed intake between the groups. Dietary inclusion of fennel followed by red pepper improved(P < 0.05) egg weight, egg production, egg mass and feed conversion ratio compared with control. Higher yolk shape index, shell and albumen weight percentages and Haugh unit(P < 0.05)were recorded in the fennel supplemented group compared with control. The egg yolk color score increased by the addition of fennel or hot red pepper in laying hen diets compared with control. The inclusion of black cumin or hot red pepper decreased serum and egg yolk cholesterol and malondialdehyde concentrations(P < 0.05) compared with control. Serum aspartate aminotransferase concentration was lower in black cumin group(P < 0.05) than in other treatments. In conclusion, the best laying performance and egg quality were obtained by dietary inclusion of fennel, followed by hot red pepper and black cumin. Dietary supplementation of black cumin or red pepper may lead to the development of low-cholesterol concentration and better antioxidant capacity of eggs. | Reham Abou-Elkhair Shaimaa Selim Eman Hussein | 2018 | Animal Nutrition2018，，4： | 6 |
| 5 | Ten years of spasers and plasmonic nanolasers显示文摘Ten years ago,three teams experimentally demonstrated the first spasers,or plasmonic nanolasers,after the spaser concept was first proposed theoretically in 2003.An overview of the significant progress achieved over the last 10 years is presented here,together with the original context of and motivations for this research.After a general introduction,we first summarize the fundamental properties of spasers and discuss the major motivations that led to the first demonstrations of spasers and nanolasers.This is followed by an overview of crucial technological progress,including lasing threshold reduction,dynamic modulation,room-temperature operation,electrical injection,the control and improvement of spasers,the array operation of spasers,and selected applications of single-particle spasers.Research prospects are presented in relation to several directions of development,including further miniaturization,the relationship with Bose-Einstein condensation,novel spaser-based interconnects,and other features of spasers and plasmonic lasers that have yet to be realized or challenges that are still to be overcome. | Shaimaa I.Azzam Alexander V.Kildishev Ren-Min Ma Cun-Zheng Ning Rupert Oulton Vladimir M.Shalaev Mark I.Stockman Jia-Lu Xu Xiang Zhang | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 6 | Efficient Channel Estimation Techniques for MIMO Systems with 1-Bit ADC显示文摘With a low resolution 1-bit ADC on its receiver(RX) side, MIMO with 1-bit ADC took a considerable step in the fulfillment of the hardware complexity constrains of the internet of things(IoT) PHY layer design. However, applying 1-bit ADC at MIMO RX results in severe nonlinear quantization error. By which, almost all received signal amplitude information is completely distorted. Thus, MIMO channel estimation is considered as a major barrier towards practical realization of 1-bit ADC MIMO system. In this paper, two efficient sparsity-based channel estimation techniques are proposed for 1-bit ADC MIMO systems, namely the low complexity sparsity-based channel estimation(LCSCE), and the iterative adaptive sparsity channel estimation(IASCE). In these techniques, the sparsity of the 1-bit ADC MIMO channel is exploited to propose a new adaptive and iterative compressive sensing(CS) recovery algorithm to handle the 1-bit ADC quantization effect. The proposed algorithms are tested with the state-of-the-art 1-bit ADC MIMO constant envelope modulation(MIMO-CEM). The 1-bit ADC MIMO-CEM system is chosen as it fulfills both energy and hardware complexity constraints of the IoT PHY layer. Simulation results reveal the high effectiveness of the proposed algorithms in terms of spectral efficiency(SE) and computational complexity. The proposed LCSCE reduces the computational complexity of the 1-bit ADC MIMO-CEM channel estimation by 86%, while the IASCE reduces it by 96% compared to the recent techniques of MIMO-CEM channel estimation. Moreover, the proposed LCSCE and IASCE improve the spectrum efficiency by 76 % and 73 %, respectively, compared to the recent techniques. | Hany SHussein Shaimaa Hussein Ehab Mahmoud Mohamed | 2020 | China Communications2020，17，5： | 2 |
| 7 | Whole slide images as a platform for initial diagnostics in histopathol- ogy in a medium-sized routine laboratory显示文摘 | Shaimaa A J Andr6 H Marius N | 2012 | Journal of Clinical Pathology2012，65，12： | 1 |
| 8 | Digital pathology: current status and future perspectives 显示文摘 | Shaimaa A J Andre H Paul J V D | 2012 | Histopatholo- gy2012，61，1： | 1 |
| 9 | Ability of Inactivated Yeast Powder To Adsorb Patulin from Apple Juice显示文摘 | Guo Caixia Yue Tianli Hatab Shaimaa Yuan Yahong | 2012 | EN2012，，3： | 1 |
| 10 | Determination of delta-9-tetrahydrocannabinol content of cannabis seizures in Egypt显示文摘Objective:To determine the delta-9-tetrahydrocannabinol(THC)content of cannabis seizures in Egypt.Methods:Unheated and heated extracts of cannabis seizures were prepared from the dried flowering tops and leaves(marijuana)or from the resin(hashish)and subjected to analysis using high performance liquid chromatography(HPLC).Results:The heated resin extract had the peak of THC in a relative ratio of 31.34%,while extracting the resin directly without heating contained only 18.34%of THC.On the other hand,marijuana showed minimum percentage of THC at 11.188% on heating and 9.55% without heating.Conclusions:These results indicate the high potency of the abused cannabis plant in the illicit Egyptian market. | Ahmed M.A.Souleman Alaa El-Din M.Gaafar Omar M.Abdel-Salam Shaimaa A.ElShebiney | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，3： | 1 |
| 11 | Error estimate of the DGFEM for nonlinear convection-diffusion Problems 显示文摘 | Hashim A Kashkool Shaimaa A Kadhum | 2012 | Inter- national Mathematical Forum2012，49，7： | 1 |
| 12 | Web Server Logs Preprocessing for Web Intrusion Detection显示文摘 | Shaimaa E S Mohamed I M Laila M E | 2011 | Computer and Information Science2011，，： | 1 |
| 13 | Effect of different amendments on soil chemical characteristics, grain yield and elemental content of wheat plants grown on salt-affected soil irrigated with low quality water显示文摘 | Shaimaa H. Abd Elrahman M.A.M. Mostafa T.A. Taha M.A.O. Elsharawy M.A. Eid | 2012 | Annals of Agricultural Sciences2012，，2： | 1 |
| 14 | Reduction o f Patulin in Aqueous Solution by Lactic Acid Bacteria显示文摘 | Shaimaa H Tianli Y Osama M | 2012 | Food Microbiology & Safety2012，77，4： | 1 |
| 15 | Optimal corrective actions for power systems using multi-objective genetic algorithms显示文摘 | Adel A A E E Shaimaa R S | | 0，，05： | 1 |
| 16 | Role of endoscopic ultrasound and cyst fluid tumor markers in diagnosis of pancreatic cystic lesions显示文摘BACKGROUND Pancreatic cystic lesions(PCLs) are common in clinical practice. The accurate classification and diagnosis of these lesions are crucial to avoid unnecessary treatment of benign lesions and missed opportunities for early treatment of potentially malignant lesions.AIM To evaluate the role of cyst fluid analysis of different tumor markers such as cancer antigens [e.g., cancer antigen(CA)19-9, CA72-4], carcinoembryonic antigen(CEA), serine protease inhibitor Kazal-type 1(SPINK1), interleukin 1 beta(IL1-β), vascular endothelial growth factor A(VEGF-A), and prostaglandin E2(PGE2)], amylase, and mucin stain in diagnosing pancreatic cysts and differentiating malignant from benign lesions.METHODS This study included 76 patients diagnosed with PCLs using different imaging modalities. All patients underwent endoscopic ultrasound(EUS) and EUS-fine needle aspiration(EUS-FNA) for characterization and sampling of different PCLs.RESULTS The mean age of studied patients was 47.4 ± 11.4 years, with a slight female predominance(59.2%). Mucin stain showed high statistical significance in predicting malignancy with a sensitivity of 87.1% and specificity of 95.56%. It also showed a positive predictive value and negative predictive value of 93.1% and 91.49%, respectively(P < 0.001). We found that positive mucin stain, cyst fluid glucose, SPINK1, amylase, and CEA levels had high statistical significance(P < 0.0001). In contrast, IL-1β, CA 72-4, VEGF-A, VEGFR2, and PGE2 did not show any statistical significance. Univariate regression analysis for prediction of malignancy in PCLs showed a statistically significant positive correlation with mural nodules, lymph nodes, cyst diameter, mucin stain, and cyst fluid CEA. Meanwhile, logistic multivariable regression analysis proved that mural nodules, mucin stain, and SPINK1 were independent predictors of malignancy in cystic pancreatic lesions.CONCLUSION EUS examination of cyst morphology with cytopathological analysis and cyst fluid analysis could improve the differentiation between malignant and benign pancreatic cysts. Also, CEA, glucose, and SPINK1 could be used as promising markers to predict malignant pancreatic cysts. | Hussein Hassan Okasha Abeer Abdellatef Shaimaa Elkholy Mohamad-Sherif Mogawer Ayman Yosry Magdy Elserafy Eman Medhat Hanaa Khalaf Magdy Fouad Tamer Elbaz Ahmed Ramadan Mervat E Behiry Kerolis Y William Ghada Habib Mona Kaddah Haitham Abdel-Hamid Amr Abou-Elmagd Ahmed Galal Wael A Abbas Ahmed Youssef Altonbary Mahmoud El-Ansary Aml E Abdou Hani Haggag Tarek Ali Abdellah Mohamed A Elfeki Heba Ahmed Faheem Hani M Khattab Mervat El-Ansary Safia Beshir Mohamed El-Nady | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，6： | 1 |
| 17 | Acute effect of sildenafil on myocardial isehemic territories in patients with stable coronary artery disease显示文摘 | Mohamed S Ahmed B Shaimaa M | 2014 | EPHJ2014，66，1： | 1 |
| 18 | Eco friendly adsorbents for removal of phenol from aqueous solution employing nanoparticle zero-valent iron synthesized from modified green tea bio-waste and supported on silty clay显示文摘The present research investigated a novel route for the synthesis of nanoparticle zero-valent iron(NZVI)utilizing an aqueous extract of green tea waste as a reductant with ferric chloride.Also,the supported nanoparticle zerovalent iron was synthesized using natural silty clay as a support material(SC-NZVI).The NZVI and SC-NZVI were characterized by infrared spectroscopy(FTIR),scanning electron microscope(SEM),X-ray diffraction(XRD),Brunauer–Emmett–Teller(BET),and zeta potential(ζ).The interpretation of the results demonstrated that the polyphenol and other antioxidants in green tea waste can be used as reduction and capping agents in NZVI synthesis,with silty clay an adequate support.Additionally,the experiments were carried out to explore phenol adsorption by NZVI and SC-NZVI.To determine the optimum conditions,the impact of diverse experimental factors(i.e.,initial pH,adsorbent dose,temperature,and concentration of phenol)was studied.Langmuir,Freundlich,and Tempkin isotherms were used as representatives of adsorption equilibrium.The obtained results indicated that the adsorption processes for both NZVI and SC-NZVI well fitted by the Freundlich isotherm model.The appropriateness of pseudofirstorder and pseudosecondorder kinetics was investigated.The experimental kinetics data were good explained by the second-order model.The thermodynamic parameters(ΔH0,ΔS0,andΔG0)for NZVI and SC-NZVI were determined.The maximum removal rates of phenol at optimum conditions,when adsorbed onto NZVI and SC-NZVI,were found to be 94.8%and 90.1%,respectively. | Shaimaa T.Kadhum Ghayda Yassen Alkindi Talib M.Albayati | 2021 | Chinese Journal of Chemical Engineering2021，34，8： | 1 |
| 19 | Compritol 888ATO:a multifunctional lipid excipient in drug delivery systems and nanopharmaceuticals显示文摘 | Mona H Aburahma Shaimaa M Badr-Eldin | 2014 | Expert Opin Drug Deliv2014，11，12： | 1 |
| 20 | 前段光学相干断层扫描在穿透性角膜移植术后移植上皮变化中的应用(英文)显示文摘目的:使用前段光学相干断层扫描(AS-OCT)评估在穿透性角膜移植术(PK)后角膜上皮厚度的变化,并确定上皮厚度在移植排斥反应早期检测中的作用。方法:前瞻性比较观察研究。共纳入20例20眼接受穿透性角膜移植术患者做为研究组,对照组16例16眼。术后2wk、1mo和3mo使用AS-OCT测量角膜厚度。术后3mo,与对照组排斥反应和上皮厚度及分布参数进行比较。结果:术后1mo,研究组的上、下、最大和最小上皮厚度值均显著低于术后2wk(P=0.0004,0.0001,0.0001,0.04),术后3mo与1mo相比无显著差异(P=0.4,0.1,0.8)。与术后2wk相比,1mo时上皮厚度的降低明显高于基质厚度(P=0.04)。角膜上皮厚度变化显示,研究组和对照组的角膜上皮厚度分布模式相似,出现明显的角膜水肿。但是,对照组中央角膜厚度(CCT)明显更高。结论:角膜移植术后移植物上皮重塑的定量评估显示,早期变化有助于角膜移植物厚度的显著改善。角膜上皮厚度和分布模式的变化可作为角膜移植排斥反应的指标。 | Shaimaa A Arfeen Riham SHM Allam Noha M Khalil Ghada A Nassar | 2020 | 国际眼科杂志2020，20，3： | 1 |
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