|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 2 | 化学修饰多壁碳纳米管制备碳糊电极用于伏安法测定药物和尿液中的异丙肾上腺素(英文)显示文摘A carbon paste electrode with added multiwall carbon nanotubes chemically modified with N-(3,4-dihydroxyphenethyl)- 3,5-dinitrobenzamide was used as the electrochemical sensor for the determination of trace amounts of isoprenaline. The modified electrode showed good electrocatalytic activity for the anodic oxidation of isoprenaline, which was due to a substantial decrease in the anodic overpotential. Under the optimum conditions, measurements using square wave voltammetry had a linear range in the range of 0.3 to 125.0 μmol/L of isoprenaline and a detection limit of 0.1 μmol/L. The diffusion coefficient and kinetic parameters were determined using electrochemical methods. The relative standard deviation for seven successive assays of 1.0 and 20.0 μmol/L isoprenaline were 1.9% and 2.4%, respectively.This electrochemical sensor was successfully applied for the determination of isoprenaline in human urine and injection solution samples. | Ali A.ENSAFI Hajar BAHRAMI Hassan KARIMI-MALEH Shadpour MALLAKPOUR | 2012 | 催化学报2012，33，12： | 6 |
| 3 | Synthesis and characterization of novel dopamine-derivative:Application of modified multi-wall carbon nanotubes paste electrode for electrochemical investigation显示文摘新奇多巴胺衍生物化合物, 3,5-diamino-N-(3,4-dihydroxyphenethyl ) benzamide (3,5-DAB ) 在二步被准备。在第一步多巴胺, hydrochloride 面对丙烯氧化物与 3,5-dinitrobenzoyl 氯化物被反应。在 nitro 的第二步减小,组们在量的产量在 3,5-DAB 的准备导致了。这材料用象英尺红外和 1H NMR 那样的常规分光镜的方法被描绘。另外, 3,5-DAB 的一个修改碳 nanotubes 浆糊电极的氧化还原作用反应在中立 pH 在水的答案被调查。结果证明电极进程有伪可逆的回答,与 Ep,比大(59/n ) mV 为一个可逆系统期望。最后,为在石蜡油矩阵的氧化还原作用过程的散开系数获得了使用 chronoamperometry 方法。 | Shadpour Mallakpour Mehdi Hatami Ali A.Ensafi Hassan Karimi-Maleh | 2011 | Chinese Chemical Letters2011，22，2： | 2 |
| 4 | Outcomes of tubeless percutaneous nephrolithotomy in patientswith chronic renal insufficiency显示文摘 | ETEMADIAN M MAGHSOUDI R SHADPOUR P | 2012 | Iran J Kidney Dis2012，6，3： | 1 |
| 5 | A Rare, but Life- Threatening Complication of Percutaneous Nephrolithotomy: Massive Intra - Abdominal Extravasation of Irrigation Fluid显示文摘 | Etemadian M Shadpour P Haghighi R | 2012 | Urology journal2012，9，3： | 1 |
| 6 | Efficient and novel method for surface oxidation of polypropylene in the solid phase using microwave irradiation 显示文摘 | Mallakpour Shadpour E Hajipour Abdol- Reza Zadhoush Ali | 2001 | J Appl Polym Sci2001，79，7： | 1 |
| 7 | Synthesis and characterization of silicone-modified vinyl acetate-acrylic emulsion copolymers显示文摘 | Hamid J N Shadpour M Nader M | 2006 | Progress in Organic Coatings2006，55，4： | 1 |
| 8 | Physiochemical properties of various polymer substrates and their effects on microchip electrophoresis performance 显示文摘 | Shadpour H Musyimi H Chen J f | 2006 | Journal of Chromatography A (S1945-239X)2006，1111，2： | 1 |
| 9 | Polycondensation of new optically active diacid with diisocyanates in the presence of tetrabutylammonium bromide as a green media under microwave heating显示文摘 | Shadpour Mallakpour Saghi Sepehri | 2008 | Reactive and Functional Polymers2008，，10： | 1 |
| 10 | Progress in Synthetic Polymers Based on Natural Amino Acids显示文摘 | Shadpour Mallakpour Mohammad Dinari | 2011 | Journal of Macromolecular Science, Part A2011，，8： | 1 |
| 11 | One-pot polyamidation reaction of optically active aromatic diacid containing methionine and phthalimide moieties with aromatic diamines under microwave irradiation and traditional heating显示文摘 | Shadpour Mallakpour Hojjat Seyedjamali | 2008 | European Polymer Journal2008，，11： | 1 |
| 12 | Multichannel microchip electrophoresis device fabricated in polycarbonate with an integrated contact conductivity sensor array显示文摘 | Shadpour H Hupert M L Patterson D | 2007 | Anal Chem2007，79，3： | 1 |
| 13 | A convenient strategy to functionalize carbon nanotubes with ascorbic acid and its effect on the physical and thermomechanical properties of poly(amide–imide) composites显示文摘 | Shadpour Mallakpour Amin Zadehnazari | 2014 | Journal of Solid State Chemistry2014，，： | 1 |
| 14 | Synthesis and characterization of modified vinylacetate-acrylic emulsioncopo|ymers 显示文摘 | HAMID NADER silicone Javaherian Naghash SHADPOUR Mallakpour Mokhtarian | 2006 | Progress in Organic Coating2006，55，： | 1 |
| 15 | Synthesis and characterization of new self-colored thermally stable poly(amide-ether-urethane)s based on an azo dye and different diisocyanates 显示文摘 | Shadpour Mallakpour Fatemeh Rafiemanzelat Khalil Faghihi | 2007 | Dyes and pigments2007，74，： | 1 |
| 16 | Thermally stable and optically active poly(amide-imide)s derived from 4,4'-(hexafluoroisopropylidene)-N,N'-bis-(phthaloyl-L-methionine) diacid chloride and various aromatic diamines:Synthesis and characterization显示文摘 | Shadpour Mallakpour Elaheh Kowsari | 2006 | Polymer Bulletin2006，57，： | 1 |
| 17 | Synthesis and properties of novel soluble and thermally stable optically active poly(amide-imide)s from N,N'-(4,4'-Oxydiphthaloyl)-bis-L-phenylalanine diacid chloride and aromatic diamines显示文摘 | Shadpour Mallakpour Elaheh Kowsari | 2005 | Polymer Bulletin2005，54，： | 1 |
| 18 | Is laparoscopic re-evaluation justified in cryptorchidism with previous negative open exploration显示文摘 | Shadpour P Rezaimehr B | 2012 | Endourol2012，14，3： | 1 |
| 19 | Physiochemical proper- ties of various polymer substrates and their effects on mi- crochip electrophoresis performance 显示文摘 | Shadpour H Musyimi H Chen J F | 2006 | Joumal of Chro- matography A2006，1111，2： | 1 |
| 20 | Pediatric percutaneous nephrolithotomy using adult sized instruments: our experience显示文摘 | Etemadian M Maghsoudi R Shadpour P | 2012 | Urol J2012，9，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员