|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review显示文摘Background:The coronavirus disease(COVID-19)has been identified as the cause of an outbreak of respiratory illness in Wuhan,Hubei Province,China beginning in December 2019.As of 31 January 2020,this epidemic had spread to 19 countries with 11791 confirmed cases,including 213 deaths.The World Health Organization has declared it a Public Health Emergency of International Concern.Methods:A scoping review was conducted following the methodological framework suggested by Arksey and O'Malley.In this scoping review,65 research articles published before 31 January 2020 were analyzed and discussed to better understand the epidemiology,causes,clinical diagnosis,prevention and control of this virus.The research domains,dates of publication,journal language,authors'affiliations,and methodological characteristics were included in the analysis.All the findings and statements in this review regarding the outbreak are based on published information as listed in the references.Results:Most of the publications were written using the English language(89.2%).The largest proportion of published articles were related to causes(38.5%)and a majority(67.7%)were published by Chinese scholars.Research articles initially focused on causes,but over time there was an increase of the articles related to prevention and control.Studies thus far have shown that the virus7 origination is in connection to a seafood market in Wuhan,but specific animal associations have not been confirmed.Reported symptoms include fever,cough,fatigue,pneumonia,headache,diarrhea,hemoptysis,and dyspnea.Preventive measures such as masks,hand hygiene practices,avoidance of public contact,case detection,contact tracing,and quarantines have been discussed as ways to reduce transmission.To date,no specific antiviral treatment has proven effective;hence,infected people primarily rely on symptomatic treatment and supportive care.Conclusions:There has been a rapid surge in research in response to the outbreak of COVID-19.During this early period,published research primarily explored the epidemiology,causes,clinical manifestation and diagnosis,as well as prevention and control of the novel coronavirus.Although these studies are relevant to control the current public emergency,more high-quality research is needed to provide valid and reliable ways to manage this kind of public health emergency in both the short-and long-term. | Sasmita Poudel Adhikari Sha Meng Yu-Ju Wu Yu-Ping Mao Rui-Xue Ye Qing-Zhi Wang Chang Sun Sean Sylvia Scott Rozelle Hein Raat Huan Zhou | 2020 | Infectious Diseases of Poverty2020，9，2： | 28 |
| 2 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 3 | Wavelength Dispersion Analysis on Fiber-Optic Raman Distributed Temperature Sensor System显示文摘 | Weijie WANG Jun CHANG Guangping LV Zongliang WANG Zhi LIU Sha LUO Shuo JIANG Xiangzhi LIU Xiaohui LIU Yongning LIU | 2013 | Photonic Sensors2013，3，3： | 9 |
| 4 | NYD-SP27,a novel intrinsic decapacitation factor in sperm显示文摘Prior to fertilization sperm has to undergo an activation process known as capaciation,leading to the acrosome reaction.Till now,little is known about the mechanism for preventing premature capacitation in sperm although decapacitation factors from various sources have been thought to be involved.In this study,we report that NYD-SP27,an isoform of phospholipase C Zeta 1(PLCZ1),is localized to the sperm acrosome in mouse and human spermatozoa by immunofluorescence using a specific antibody.Western blot and double staining analyses show NYD-SP27 becomes detached from sperm,as they undergo capacitation and acrosome reaction.The absence of HCO_(3)^(-),a key factor in activating capacitation,from the capacitation-inducing medium prevents the loss of NYD-SP27 from sperm.The anti-NYD-SP27 antibody also prevents the loss of NYD-SP27 from sperm,reduced the number of capacitated sperm,inhibited the acrosome reaction induced by ATP and progesterone,and inhibited agonist-induced PLC-coupled Ca^(2+)mobilization in sperm,which can be mimicked by the PLC inhibitor,U73122.These data strongly suggest that NYD-SP27 is a physiological inhibitor of PLC that acts as an intrinsic decapacitation factor in sperm to prevent premature capacitation and acrosome reaction. | Ye Bi Wen-Ming Xu Hau Yan Wong Hui Zhu Zuo-Min Zhou Hsiao Chang Chan Jia-Hao Sha | 2009 | Asian Journal of Andrology2009，11，2： | 8 |
| 5 | Purification and Characterization of a Low-temperature Hydroxylamine Oxidase from Heterotrophic Nitrifier Acinetobacter sp.Y16显示文摘Objective To purify a low-temperature hydroxylamine oxidase(HAO) from a heterotrophic nitrifying bacterium Acinetobacter sp.Y16 and investigate the enzyme property.Methods A HAO was purified by an anion-exchange and gel-filtration chromatography from strain Y16.The purity and molecular mass were determined by RP-HPLC and SDS-PAGE.The HAO activity was detected by monitoring the reduction of potassium ferricyanide using hydroxylamine as substrate and ferricyanide as electron acceptor.The partial amino acid sequence was determined by mass spectrometry.Results The low-temperature HAO with a molecular mass of 61 kDa was purified from strain Y16 by an anion-exchange and gel-filtration chromatography.The enzyme exhibited an ability to oxidize hydroxylamine in wide temperature range(4-40 ℃) in vitro using hydroxylamine as substrate and ferricyanide as electron acceptor.It was stable in the temperature range of 4 to 15 ℃ and pH range of6.0 to 8.5 with less than 30%change in its activity.The optimal temperature and pH were 15 ℃ and 7.5,respectively.Three peptides were determined by mass spectrometry which were shown to be not identical to other reported HAOs.Conclusion This is the first study to purify a low-temperature HAO from a heterotrophic nitrifier Acinetobacter sp.It differs from other reported HAOs in molecular mass and enzyme properties.The findings of the present study have suggested that the strain Y16 passes through a hydroxylamine-oxidizing process catalyzed by a low-temperature HAO for ammonium removal. | ZHANG Shu Mei LI Wei Guang ZHANG Duo Ying HUANG Xiao Fei QIN Wen SHA Chang Qing | 2014 | Biomedical and Environmental Sciences2014，27，7： | 6 |
| 6 | Electrochemical behavior of microbiologically influenced corrosion on Fe_3Al in marine environment显示文摘In this article,microbiologically influenced corrosion behavior of Fe3Al intermetal-lic compound in microorganism culture medium has been investigated by using weight loss methods,electrochemical techniques,and electron microscopy.Polar-ization curves showed that a sharp electrical current peak caused by surface pitting could be observed after Fe3Al electrodes were immersed in culture medium for 15 days when the polarization potential was about-790 mV vs SCE.Based on the electrochemical impedance spectroscopy(EIS)and the equivalent circuit parameters of the associated system,the corrosion products were found to exhibit a two-layer structured feature and the microorganisms could induce pitting and erosion corrosion of the inner layer.In addition,the passivating film of the inner layer was absolutely destroyed by microbial metabolic products. | Xueting CHANG Shougang CHEN Guanhui GAO Yansheng YIN Sha CHENG Tao LIU | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，4： | 5 |
| 7 | A Processive Arabidopsis Formin Modulates Actin Filament Dynamics in Association with Profilin显示文摘Formins 是被含有为房间分割和房间极性重要的肌动朊细胞骨架组织和动力学的保存管理者。由哪个多样的 formins 在植物调整肌动朊动力学的机制仍然不好被理解。在 vitro 使用单个分子的成像技术,我们直接观察到 Arabidopsis thaliana formin 的 FH1-FH2 领域, AtFH14, processively 属于是的肌动朊细丝的有倒钩的目的一更暗淡并且在 90% 减缓他们的延伸率。FH1-FH2 的附件坚持是集中依赖者。由三倍颜色的全部的内部思考荧光显微镜学的使用,而且,我们发现了那 ABP29,有倒钩结束的盖住蛋白质,在细丝与 FH1-FH2 竞争有倒钩的结束,在它的绑定与 AtFH14 是互相独占的的地方。面对不同植物 profilin isoforms, FH1-FH2 从大约 10 ~ 42 次提高细丝延伸率。细丝扣环当 FH1-FH2 明确地被抛锚盖住幻灯片时,推进显示 AtFH14 在伸长上 processively 移动有倒钩的结束。在高集中, AtFH14 随机绑肌动朊细丝进反平行或平行的像锭子的结构;然而, FH1-FH2-mediated 捆变得面对植物 profilins 更薄、更长。这是从植物的 processive formin 的直接示范。我们的结果也在与 profilin 经由协会调整肌动朊动力学照亮 AtFH14 的分子的机制。 | Sha Zhang Chang Liu Jiaojiao Wang Zhanhong Ren Christopher J. Staiger Haiyun Ren | 2016 | Molecular Plant2016，9，6： | 5 |
| 8 | Application of Wavelet Transform Modulus Maxima in Raman Distributed Temperature Sensors显示文摘我们建议了并且示威小浪变换模量降噪方法减少的最大值(WTMM ) 温度错误。在这个计划,作文规模被 WTMM 振幅变化在 30 摯汵瑡潩 ? 整档楮畱与分解规模的生长简单地决定吗? | Zongliang WANG Jun CHANG Sasa ZHANG Sha LUO Cuanwu JIA Boning SUN Shuo JIANG Yongning LIU Xiaohui LIU Guangping LV Zhi LIU | 2014 | Photonic Sensors2014，4，2： | 5 |
| 9 | Combined detection and subclass characteristics analysis of CTCs and CTECs by SE-iFISH in ovarian cancer显示文摘Objective:Hematogenous metastasis is essential for the progression of ovarian cancer(OC),and circulating tumor cells(CTCs)are part of the metastatic cascade.However,the detection rate of CTC is low due to the use of less sensitive detection methods.Therefore,this study aimed to detect CTCs and circulating tumorigenic endothelial cells(CTECs)in patients with OC using subtraction enrichment and immunostaining and fluorescence in situ hybridization(SE-iFISH).Methods:We enrolled a total of 56 subjects,including 20 OC patients and 36 ovarian benign tumor patients.CTCs and CTECs were captured by subtraction enrichment(SE)and counted and classified according to immunofluorescence staining of tumor markers(TMs)carbohydrate antigen 125(CA125)and human epididymis protein 4(HE4)combined with fluorescence in situ hybridization(iFISH)of chromosome 8(Chr8)aneuploidy.The diagnostic value and subtype characteristics of CTCs and CTECs were investigated.Results:The detection rate of CTCs by SE-iFISH was high.Compared with CA125 and HE4,Chr8 aneuploidy was the major identification feature of CTC.CTC counts in OC were statistically higher than those in benign groups.CTC and CTEC with≥pentaploidy were detected in both groups,illustrating the poor diagnostic value of CTC or CTEC.Distributions of triploid and tetraploid CTC subtypes were significantly different,and combined detection of triploid and tetraploid CTCs showed the best diagnostic value.In contrast,the distribution of CTECs in the OC and benign groups had no statistically significant difference.Small CTCs accounted for over 1/3 of the total CTC count.We also found that small CTCs and CTECs primarily comprised triploid cells,while large CTCs and CTECs mainly comprised pentaploidy and beyond.Conclusions:The application of SE-iFISH offered a more comprehensive understanding of heterogeneous CTCs and CTECs in OC.Analysis of subclass characteristics of the CTCs and CTECs according to Chr8 aneuploidy and cell size may broaden their potential clinical utility and deepen mechanistic studies in OC. | Hongyan Cheng Shang Wang Wenqing Luan Xue Ye Sha Dou Zhijian Tang Honglan Zhu Peter Ping Lin Yi Li Heng Cui Xiaohong Chang | 2021 | Chinese Journal of Cancer Research2021，33，2： | 3 |
| 10 | Soluplus micelles for improving the oral bioavailability of scopoletin and their hypouricemic effect in vivo显示文摘Scopoletin 是拥有许多药理学活动的活跃香豆素,包括 anti-hyperuricemic 效果,但是与差的溶解度。改进它的口头的 bioavailability,我们试图包含 scopoletin 进 Soluplus 微粒(基于 Soluplus 的 scopoletin 微粒, Sco 女士) 并且评估了 Sco-Ms.Sco 女士的 hypouricemic 行动用一个薄电影的水和方法被准备。Sco 女士与 59.4 灭敬整祬戠潬正摥 ? 噓木椭摮 ' 讚?的一种平均尺寸显示了近球形的形状 ?? 桰獯桰牯汹瑡潩 ? 猠杵敧瑳湩 ? 桴瑡 ??? ‵捡楴杮甠獰牴慥? 景 ?? 愠摮瀠??偁欠湩獡 | Ying-chun ZENG Sha LI Chang LIU Tao GONG Xun SUN Yao FU Zhi-rong ZHANG | 2017 | Acta Pharmacologica Sinica2017，38，3： | 3 |
| 11 | SAR Image Despeckling Using Scale Mixtures of Gaussians in the Nonsubsampled Contourlet Domain显示文摘The edge and contour details in SAR images are important for subsequent processing tasks. The multiscale geometric analysis method — Nonsubsampled contourlet transform(NSCT) is able to capture the geometric information of SAR images effectively. Describing the aggregation behavior of the neighborhoods coefficients, the scale mixtures of Gaussians model has exhibited favorable performances. A novel SAR image despeckling method is presented by constructing the scale mixtures of Gaussians model of NSCT. This method models the SAR images using the multiscale and multidirection information in NSCT domain. The dependency relationship of NSCT neighborhoods coefficients are also taken into consideration in our model. The speckle noise coefficients are shrinkaged by statistical prior estimation based on SAR image model constructed. Experimental results demonstrate that our method is advantageous at directional information preservation and the speckle restraint. | CHANG Xia JIAO Licheng LIU Fang SHA Yuheng | 2015 | Chinese Journal of Electronics2015，24，1： | 2 |
| 12 | A Method for Eliminating the Impact of Microwave Sweeper Power Fluctuation in BOTDA System显示文摘在 BOTDA 系统的微波 sweeper 电源变化的影响理论上被分析了并且试验性地测试了。并且把探查波浪电源的即时获得与一个新算法作比较为消除这影响认识到探查波浪电源正规化的一个新奇方法被建议。建议方法的原则理论上被描述。并且在我们的新方法和常规方法之间的对比测试被执行。实验结果显示温度精确性有效地被改进从 ? | Shuo Jiang Jun Chang Sasa Zhang Zongliang Wang Sha Luo Boning Sun Xiaohui Liu Yongning Liu Junqiang Tian Chuanwu Jia | 2014 | Photonic Sensors2014，4，1： | 2 |
| 13 | Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities显示文摘Six new triterpenoid saponins,aesculusosides A-F(1-6),together with 19 known ones,were isolated from the seeds of Aesculus chinensis.The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data.Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay,and compounds 15,16,19,and 23-25 exhibited inhibitory activities against MCF-7 with IC50 values ranging from 7.1 to 31.3μM. | Jin-Tang Cheng Shi-Tao Chen Cong Guo Meng-Jiao Jiao Wen-Jin Cui Shu-Hui Wang Zhe Deng Chang Chen Sha Chen Jun Zhang An Liu | 2018 | Natural Products and Bioprospecting2018，8，1： | 2 |
| 14 | Design and evaluation of glomerulus mesangium-targeted PEG-PLGA nanoparticles loaded with dexamethasone acetate显示文摘Mesangial proliferative glomerulonephritis (MsPGN),one of the most common glomerulonephritis pathological types,often leads to end-stage renal disease over a prolonged period.But the current treatment of MsPGN is non-specific and causes serious side effects,thus novel therapeutics and targeting strategies are urgently demanded.By combining the advantages of PEG-PLGA nanoparticles and the size selection mechanism of renal glomerulus,we designed and developed a novel PEG-PLGA nanoparticle delivery system capable of delivering dexamethasone acetate (A-DEX)into glomerular mesangium.We determined that 90 nm was the optimum size to encapsulate A-DEX for glomerular mesangium targeting based on the size-selection mechanism of glomerulus. After intravenous administration in rats,90 nm DiD-loaded NPs were found to accumulate to a greater extent in the kidney and kidneycortex compared with the free DiD solution.The 90 nm A-DEX NPs are also more stable at room temperature and showed a sustained release pattern.In rat glomerular mesangial cells (HBZY-1)in vitro,we found that the uptake of 90 nm A-DEX NPs was both temperature-dependent and energe-dependent,and they were mostly engulfed via clathrin-dependent endocytosis pathways,in summary,we have successfully developed a glomerular mesangium-targeted PEG-PLGA NPs,which is potential for the treatment of MsPGN. | Sha Li Ying-chun Zeng Ke Peng Chang Liu Zhi-rong Zhang Ling Zhang | 2019 | Acta Pharmacologica Sinica2019，40，1： | 2 |
| 15 | Microbially influenced corrosion of stainless steel by marine bacterium Vibrio natriegens : (I) Corrosion behavior显示文摘 | Sha Cheng Jintao Tian Shougang Chen Yanhua Lei Xueting Chang Tao Liu Yansheng Yin | 2008 | Materials Science & Engineering C2008，，3： | 1 |
| 16 | Polymersomes:From Macromolecular Self-Assembly to Particle Assembly显示文摘What is the most favorite and original chemistry developed in your research group?Ring-opening polymerization-induced self-assembly of N-carboxyanhydrides(NCA-PISA),and fusion-induced particle assembly(FIPA).How do you get into this specific field?Could you please share some experiences with our readers?NCA-PISA was developed to solve the biodegradability problem of nanoparticles by traditional PISA,while FIPA was inspired by nature. | Jiamin Zhang Jinhui Jiang Sha Lin Erik Jan Cornel Chang Li Jjianzhong Du | 2022 | Chinese Journal of Chemistry2022，40，15： | 1 |
| 17 | Consumption and Stock Markets in Greater China 显示文摘 | Xiaohui Liu and Chang Sha | 2004 | Applied Economics Letters2004，，11： | 1 |
| 18 | Plasma etching of high dielectric constant materials on silicon in halogen chemistries显示文摘 | SHA L CHANG J P | 2004 | J Vac Sci Technol A2004，22，1： | 1 |
| 19 | Thermo and pH dualresponsive, polymer shell coated, magnetic mesoporous silicananoparticles for controlled drug release 显示文摘 | Chang B Sha X Guo J | 2011 | J Mat Chem2011，21，25： | 1 |
| 20 | Near-field electrospinning显示文摘 | SUN Daoheng CHANG Chi LI Sha | 2006 | Nano Lett2006，6，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员