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123篇 您的检索式:作者名="Sexton E"
    题名 作者 年代 出处 被引量
1向在人的察觉到钙的受体的 allosteric 药的结构的理解显示文摘allosterically 指向人的察觉到钙的受体(CaSR ) 的药有实质的治疗学的潜力,但是当前被限制。给 CaSR 的高分辨率的结构的缺席,我们把 mutagenesis 与一条新奇分析途径并且开发 “ 的分子的建模相结合; enriched”为在 Ca 2+ 在 CaSRs 7 transmembrane (7TM ) 以内的 o 和 allosteric 调节的人领域。修改多重有约束力的地点以适应在结构上的一个扩大的洞多样的 ligands 被识别。Phenylalkylamines 绑在与通常认为的 Ca 2+ o -binding 地点并且向一个细胞外的门厅延长。相反,在结构上和 pharmacologically 不同的 AC-265347 在 7TM 领域以内更深绑。而且,不同氨基酸网络被发现调停由不同调节的人的 cooperativity。这些调查结果可以与不同、潜在地偏导小径的药理学效果便于 allosteric 调节的人的合理设计。Katie Leach Karen J Gregory Irina Kufareva Elham Khajehali Anna E Cook Ruben Abagyan Arthur D Conigrave Patrick M Sexton Arthur Christopoulos 2016Cell Research2016,26,5:2
2Gender differences in returns to and the acquisition of on-the-job training显示文摘Olsen R N Sexton E A 1996Industrial Relations1996,35,1:1
3Bean abscission cellulase:Characterization of a cDNA clone and regulation of gene expression by ethylene and auxin显示文摘TUCKER ML SEXTON R DEL CAMPLLLO E 1955Plant Physiol1955,88,:1
4The impact of overactive bladder, incontinence and other lower urinary tract symptoms On quality of life, work productivity, sexuality and emotional well-being in men and women: results from the EPIC study显示文摘Coyne K Sv Sexton C Cv Irwin D E et a1 2008BJU Int2008,101,11:1
5Development of cerium-based conversion coatings on 2024-T3 A1 alloy after rare-earth desmutting 显示文摘HUGHES A E GORMAN J D MILLER P R SEXTON B A PATERSON P J K TAYLOR R J 2004Surface and Interface Analysis2004,36,44:1
6AKT involvement in cispla- tin chemoresistance of human uterine cancer cells显示文摘Gagnon V Mathieu 1 Sexton E 2004Gyneeol Oncol2004,94,3:1
7Fine-root decomposition and N dynamic in coniferous forests of the Pacific Northwest, USA 显示文摘Chen H Harmon M E Sexton J 2002Cana- dian Journal of Forest Research2002,32,2:1
8The Effect of Education and Experience on Self - employment Success 显示文摘ROBINSON P SEXTON E A 1994Journal of Business Venturing1994,9,:1
9The effect of rosuv- astatin on platelet-leukocyte interactions in the setting of acute cor- onary syndrome显示文摘Sexton T R Wallace E L Macaulay T E 2015J Am Coll Cardiol2015,65,3:1
10An XPS study of coke distribution on ZSM-5 显示文摘SEXTON B A HUGHES A E BIBBY D M 1988Journal of Catalysis1988,109,1:1
11Fine-root decomposition and N dynamics in coniferous forests of the Pacific Northwest,USA显示文摘CHEN H HARMON M E SEXTON J 2002Can J For Res2002,32,:1
12The effect of education and experience on self-employment success 显示文摘ROBINSON P SEXTON E 1994Journal of Business Venturing1994,,9:1
13An XPS study of coke distribution on ZSM-5显示文摘Sexton B A Hughes A E Bibby D M 1988Journal of Catalysis1988,109,1:1
14Adult prostate sarcoma:The anderson cancer center experience显示文摘Sexton W J Lance R E Reyes A O 2001J Urol2001,166,:1
15Reliable classification using neural networks:a genetic algorithm and backpropagation comparison显示文摘SEXTON R S DORSEY R E 2000Decision Support Systems2000,30,1:1
16Error stress and teamwork in medicine and aviation: Cross sectional surveys显示文摘Sexton J Thomas E Heimreich R 2000Br Med J2000,320,7237:1
17AKT involvement in cisplatin chemoresistance of human uterine cancer cells显示文摘GAGNON V MATHIEU I SEXTON E 2004Gynecologic Oncology2004,94,3:1
18The Effect of Executive Walk Rounds on Nurse Safety Climate Attitudes:A Randomized Trial of Clinical Units显示文摘Thomas E J Sexton J B Neilands T B 2005BMC Health Serv Res2005,5,1:1
19Operation of lead-acid batteries for HEV applications 显示文摘OLSON B SEXTON E D 2000Battery Conference on Applications and Advances2000,1,:1
20Reliable classification using neural networks:a genetic algorithm and backpropagation comparison显示文摘 Dorsey R E 2000Decision Support Systems2000,30,1:1
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