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| 1 | Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review显示文摘AIM: To investigate roles of genetic polymorphisms in non-alcoholic fatty liver disease(NAFLD) onset, severity, and outcome through systematic literature review. METHODS: The authors conducted both systematic and specific searches of Pub Med through December 2015 with special emphasis on more recent data(from 2012 onward) while still drawing from more historical data for background. We identified several specific genetic polymorphisms that have been most researched and, at this time, appear to have the greatest clinical significance on NAFLD and similar hepatic diseases. These were further investigated to assess their specific effects on disease onset and progression and the mechanisms by which these effects occur. RESULTS: We focus particularly on genetic polymorphisms of the following genes: PNPLA3, particularly the p. I148 M variant, TM6SF2, particularly the p. E167 K variant, and on variants in FTO, LIPA, IFNλ4, and iron metabolism, specifically focusing on HFE, and HMOX-1. We discuss the effect of these genetic variations and their resultant protein variants on the onset of fatty liver disease and its severity, including the effect on likelihood of progression to cirrhosis and hepatocellular carcinoma. While our principal focus is on NAFLD, we also discuss briefly effects of some of the variants on development and severity of other hepatic diseases, including hepatitis C and alcoholic liver disease. These results are briefly discussed in terms of clinical application and future potential for personalized medicine. CONCLUSION: Polymorphisms and genetic factors of several genes contribute to NAFLD and its end results. These genes hold keys to future improvements in diagnosis and management. | Tyler J Severson Siddesh Besur Herbert L Bonkovsky | 2016 | World Journal of Gastroenterology2016，22，29： | 12 |
| 2 | Characterization of the Hantaan nucleocapsid protein-ribonucleic acid interaction显示文摘 | Severson W Partin L Schmaljohn C S | 1999 | J Biol Chem1999，274，33： | 2 |
| 3 | Apolipoprotein VLDL-II inhibits lipolysis of triglyceride-rich lipoproteins in the laying hen显示文摘 | Schneider W J Carroll R Severson D L | 1990 | J Lipid Res1990，31，3： | 1 |
| 4 | Variation of flavor components on leaf surfaces of tobacco genotypes differing in trichome density显示文摘 | NIELSON M T SEVERSON R F | 1990 | Agric Food Chem1990，38，： | 1 |
| 5 | Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis显示文摘 | Kaur B Khwaja FW Severson EA | 2005 | Neuro-oncol2005，7，： | 1 |
| 6 | Insect Biochem显示文摘 | SEVERSON DW WILLIAMSON JL AIKEN JM | 1989 | Honeybee1989，19，2： | 1 |
| 7 | Leaf surface chemicals from Nicotiana affecting germination of Peronospora tabacina (Adam) sporangia 显示文摘 | Kennedy B S Nielsen M T Severson R F | 1992 | J Chem Ecol1992，18，： | 1 |
| 8 | Apolipoprotein VLDL-II inhibits lipolysis of triglycer- ide-rich lipoproteins in the laying hen 显示文摘 | SCHNEIDER W J CARROLL R SEVERSON D L | 1990 | Journal ofLipid Research1990，31，3： | 1 |
| 9 | Chromosomal regions associated with segregation distortion in maize 显示文摘 | Lu H Romero Severson J Bernardo R | 2002 | Theoreti cal and Applied Genetics2002，105，62： | 1 |
| 10 | Chromosomal regions associated with segregation distortion in maize显示文摘 | Lu H Romero severson J Bernardo R | 2002 | Theoretical and Applied Genetics2002，105，： | 1 |
| 11 | Gas chromatographic method for the determination of free and total solanesol in tobacco显示文摘 | Severson R F Ellington J T Schotzhauer P F | 1997 | J Chromatogr1997，，： | 1 |
| 12 | Inheritance of sucrose esters containing beta-methylvaleric acid in tobacco显示文摘 | Gwynn G R Severson R F Jackson D M | 1985 | Tobacco Science1985，29，： | 1 |
| 13 | Neurovascular anatomy:a practical guide显示文摘 | Bell R Severson MA 3rd Armonda RA | | 0，，03： | 1 |
| 14 | The antibacterial lectin Reg ]]I 7 promotes the spatial segregation of microbiota and host in the intestine显示文摘 | Vaishnava S Yamamoto M Severson KM | 2011 | Science2011，334，6053： | 1 |
| 15 | High-throughput screening of a 100,000-compound library for inhibitors of influenza A virus (H3N2)显示文摘 | Severson W E McDowell M Ananthan S | 2008 | J Biomol Screen2008，13，9： | 1 |
| 16 | Leaf surface chemistry of tobacco budworm resistant tobacco显示文摘 | Johonson A W Severson R F | 1984 | J Agric Entomol1984，，1： | 1 |
| 17 | Indoleacetic acid production by the fungal endophyte of tall fescue显示文摘 | DeBattista J P Bacon C W Severson R | 1990 | Agronomy1990，82，： | 1 |
| 18 | Gas chromatographic method for the determination of free solanesol and total solanesol in tobacco显示文摘 | Severson R F Ellington J J Schlotzhauer P F | 1977 | J Chromat1977，139，： | 1 |
| 19 | Arterial calcificate and not lumen stenosis is highly correlated with at herosclerotic plaque burden in humans显示文摘 | Sangiorgi G Rumberger JA Severson A | | 0，，01： | 1 |
| 20 | Snail2 controls mesodermal BMP/Wnt induction of neural crest 显示文摘 | Shi J Severson C Yang J | 2011 | Development2011，138，15： | 1 |
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