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| 1 | Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome显示文摘Polycystic ovary syndrome(PCOS) is the most common endocrine disorder in reproductive-aged women. Women with PCOS frequently have metabolic complications including insulin resistance(IR), early diabetes, hypertension and dyslipidemia. Recent studies have demonstrated an association between PCOS and another metabolic complication: nonalcoholic fatty liver disease(NAFLD). NAFLD occurs as a result of abnormal lipid handling by the liver, which sensitizes the liver to injury and inflammation. It can progress to nonalcoholic steatohepatitis(NASH), which is characterized by hepatocyte injury and apoptosis. With time and further inflammation, NASH can progress to cirrhosis. Thus, given the young age at which NAFLD may occur in PCOS, these women may be at significant risk for progressive hepatic injury over the course of their lives. Many potential links between PCOS and NAFLD have been proposed, most notably IR and hyperandrogenemia. Further studies are needed to clarify the association between PCOS and NAFLD. In the interim, clinicians should be aware of this connection and consider screening for NAFLD in PCOS patients who have other metabolic risk factors. The optimal method of screening is unknown. However, measuring alanine aminotransferase and/or obtaining ultrasound on high-risk patients can be considered. First line treatment consists of lifestyle interventions and weight loss, with possible pharmacologic interventions in some cases. | Carly E Kelley Ann J Brown Anna Mae Diehl Tracy L Setji | 2014 | World Journal of Gastroenterology2014，20，39： | 11 |
| 2 | Polycystic ovary syndrome : diag- nosis and treatment 显示文摘 | SETJI T L BROWN A J | 2007 | The American Journal of Medi- cine2007，120，2： | 1 |
| 3 | Polycystic ovary syndrome:update on diagnosis and treatment显示文摘 | Setji TL Brown AJ | 2014 | Am J Med2014，127，10： | 1 |
| 4 | Polycystic ovary syndrome:diagnosis and treatment显示文摘 | Setji TL Brown AJ | | 0，，2： | 1 |
| 5 | Effects of exercise on lipoprotein particles in women with polycystic ovary syndrome显示文摘 | Brown AJ Setji TL Sanders LL | 2009 | Med Sci Sports Exerc2009，41，3： | 1 |
| 6 | Gestational diabetemellitus显示文摘 | Setji TL Brown AJ Feinglos MN | 2005 | Clin Diabet[J]2005，23，1： | 1 |
| 7 | Nonalcoholic steatohepatitis and nonalcoholic fatty liver disease in young women with polycystic ovary syndrome显示文摘 | Setji TL Uand ND Sanders LL | | 0，，： | 1 |
| 8 | Effects of exercise on lipopro- tein particles in women with polycystic ovary syndrome 显示文摘 | Brown AJ Setji TL Sanders LL | 2009 | Medicine and Science in Sports and Exercise2009，41，3： | 1 |
| 9 | Polycystic ovary syndrome:diagnosis and treatment显示文摘 | SETJI TL BROWN AJ | 2007 | Am J Med2007，120，2： | 1 |
| 10 | Gestational diabetes mellitus 显示文摘 | Setji T L Brown A J Feinglos M N | 2005 | Clinical Diabetes2005，23，1： | 1 |
| 11 | Polycystic ovary syndrome:update on diagnosis and treatment 显示文摘 | Setji TL Brown AJ | 2014 | Am J Med2014，127，10： | 1 |
| 12 | Polycystic ovary syndrome: diagnosis and treatment 显示文摘 | Setji TL Brown AJ | 2007 | Am J Med2007，120，2： | 1 |
| 13 | Comprehensive clinical management of polycystic ovary syndrome显示文摘 | Setji TL Brown AJ | 2007 | Minerva Med2007，98，3： | 1 |
| 14 | Nonalcoholic steatohepa?titis and nonalcoholic fatty liver disease in young women with poly?cystic ovary syndrome显示文摘 | Setji TL Holland ND Sanders LL | 2006 | J Clin Endocrinol Metab2006，91，5： | 1 |
| 15 | Gestational diabetes mellitus显示文摘 | SETJI T L BROWN A J FEINGLOS M N | 2005 | Clinical Diabetes2005，23，1： | 1 |
| 16 | cDNA from Hevea brasiliensis latex encoding 1 - Deoxy - D - xylulose - 5 - phosphate reductoisomerase显示文摘 | KRUEAWAN Y SEtJI T ATIYA R | 2008 | Plant Sci2008，175，： | 1 |
| 17 | Nonalcoholic steatohepatitis and nonalcoholic Fatty liver disease in young women with polycystic ovary syndrome显示文摘 | Setji TL | 2006 | J Clin Endocrinol Metab2006，91，5： | 1 |
| 18 | Higher high-density lipoprotein cholesterol in African-American women with polycystic ovary syndrome compared with Caucasian counterparts 显示文摘 | Koval KW Setji TL Reyes E | 2010 | J Clin Endocrinol Metab2010，95，9： | 1 |
| 19 | Polyeystic ovary syndrome:diagnosis and treatment显示文摘 | Setji TL Brown AJ | 2007 | Am J Med2007，120，： | 1 |
| 20 | Polycystic ovary syndrome:diagnosis and treatment显示文摘 | Setji TL Brown AJ | 2007 | Am J Med2007，120，： | 1 |
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