| 1 | Analysis of the genetic interactions between Cyclin A1, Atm and p53 during spermatogenesis显示文摘瞄准:在精子发生和 DNA 双海滨裂缝修理与 p53 和 Atm 分析 Cyclin 的功能的相互作用。方法:两倍猛烈老鼠的二根线被产生。精子发生和两倍海滨裂缝修理机制在 Cyclin A1 (Ccnal ) 被分析;p53- 和 Ccnal;Atm -- 两倍猛烈老鼠。结果:在在 mid-diplotene 阶段在 Cyclin A1-/-(Ccnal-/-) 睾丸观察的精子发生的块与 polynucleated 巨人房间被联系。我们发现 Ccnal 缺乏的睾丸和特别巨大的房间积累 DNA 双海滨打破,为 phosphorylated H2AX 由免疫组织化学检测了的 unrepaired。另外,巨大的房间逃离 apoptosis。因为睾丸缺乏 ATM,它为 develop 精子发生的所知比前期Ⅰ早逮捕,巨大的房间的发展发生在 meiotic 前期Ⅰ,别当 cyclin A1 不在时开发巨大的房间。Cyclin A1 与 CDK2 在建筑群与 p53 和 phosphorylated p53 交往了。有趣地, p53 缺乏显著地在 Ccnal 缺乏的睾丸增加了巨大的房间的数字。在变异的睾丸的 DNA 修理基因的一块面板的基因表达式分析表明任何一个都一致地没当 cyclin A1 不在时检验的基因被调整。结论:在精子发生的 Ccnal 缺乏在 DNA 双海滨裂缝修理与缺点被联系,它被 p53 的损失提高。 | Nicole Baiumer Marie-Luise Sandstede Sven Diederichs Gabriele Kohler Carol Readhead Ping Ji Feng Zhang Etmar Bulk Jorg Gromoll Wolfgang E. Berdel Hubert Serve Carsten Muller-Tidow | 2007 | Asian Journal of Andrology2007，9，6： | 4 |
| 2 | Prevalence and risk factors of infertility in a Mongolian population显示文摘Objective:To investigate and analyze the prevalence and risk factors of infertility in a Mongolian population.Methods:We conducted a population-based cross-sectional study between September 2016 and November 2021.Our study population of 1919 participants consisted of residents of Ulaanbaatar city and four regions of Mongolia.A pretested standardized and structured questionnaire was used to gather data from the participants.Our questionnaire comprised categories influencing infertility,such as socioeconomic status,lifestyle factors,health,reproductive history,present status,and sexual function.In addition,trained staff conducted face-to-face interviews with the participants.Results:Our study showed an infertility incidence of 8.2%,with primary infertility at 2.76%and secondary infertility at 5.47%.Compared with the urban area of Ulaanbaatar,the prevalence of infertility was significantly higher amongst the rural population(P<0.001).Risk factors of infertility included advanced age(35-39 years,OR 1.8,95%CI 1.99-6.55;>40 years,OR 2.1,95%CI 2.62-8.55),living rural region(aOR 2.4,95%CI 1.62-3.69),alcohol consumption(aOR 1.6,95%CI 1.11-2.44),chronic diseases(aOR 1.6,95%CI 1.20-2.38),reproductive disease(aOR 2.6,95%CI 1.86-3.88),gynecological operative history(aOR 2.1,95%CI 1.38-3.21),ovarian cyst(aOR 4.2,95%CI 2.70-6.40),gonorrhea(aOR 2.4,95%CI 1.01-6.16),non-malignant uterine cancer(aOR 2.9,95%CI 1.40-6.70),and endometriosis(aOR 4.7,95%CI 1.41-15.62).Conclusions:In Mongolia,the average infertility rate is 8.2%,similar to the average worldwide and is significantly higher in rural communities.Our study shows the most significant risk factors for infertility are age,alcohol consumption,and rural living.In addition,an unfavorable gynecological history and some diseases also pose a risk to fertility. | Tuvshinbayar Negdel Arigbukh Enkhbat Badrakh Munkhbayar Khantushig Bilegsuren Ariunaa Ganbold Khuderchuluun Nanjid Carol W Readhead Lkhagva-Ochir Erkhembaatar Erkhembaatar Tuduvdorj Munkhzol Malchinkhuu Odkhuu Enkhtaivan | 2023 | Asian pacific Journal of Reproduction2023，12，3： | 0 |
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