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| 1 | Comparison of four proton pump inhibitors for the short-term treatment of esophagitis in elderly patients显示文摘AIM: To compare efficacy and tolerability of four proton pump inhibitors (PPIs) commonly used in the short-term therapy of esophagitis in elderly patients.METHODS: A total of 320 patients over 65 years with endoscopically diagnosed esophagitis were randomly assigned to one of the following treatments for 8 wk: (1) omeprazole 20 mg/d; (2) lansoprazole 30 mg/d; (3) pantoprazole 40 mg/d, or (4) rabeprazole 20 mg/d. Major symptoms, compliance, and adverse events were recorded. After 8 wk, endoscopy and clinical evaluation were repeated.RESULTS: Per protocol and intention to treat healing rates of esophagitis were: omeprazole = 81.0% and 75.0%, lansoprazole = 90.7% (P = 0.143 vs omeprazole) and 85.0%, pantoprazole = 93.5% (P = 0.04 vs omeprazole) and 90.0% (P = 0.02 vs omeprazole), rabeprazole = 94.6% (P = 0.02 vs omeprazole) and 88.8% (P = 0.04 vs omeprazole). Dividing patients according to the grades of esophagitis, omeprazole was significantly less effective than the three other PPIs in healing grade 1 esophagitis (healing rates: 81.8% vs 100%, 100% and 100%, respectively, P = 0.012). Pantoprazole and rabeprazole (100%) were more effective vs omeprazole (89.6%, P = 0.0001)and lansoprazole (82.4%, P = 0.0001) in decreasing heartburn. Pantoprazole and rabeprazole (92.2% and 90.1%, respectively) were also more effective vs lansoprazole (75.0%, P < 0.05) in decreasing acid regurgitation. Finally, pantoprazole and rabeprazole (95.2% and 100%) were also more effective vs lansoprazole (82.6%, P < 0.05) in decreasing epigastric pain.CONCLUSION: In elderly patients, pantoprazole and rabeprazole were significantly more effective than omeprazole in healing esophagitis and than omeprazole or lansoprazole in improving symptoms. H pylori infection did not influence the healing rates of esophagitis after a short-term treatment with PPI. | Alberto Pilotto Marilisa Franceschi Gioacchino Leandro Carlo Scarcelli Luigi Piero D'Ambrosio Francesco Paris Vito Annese Davide Seripa Angelo Andriulli Francesco Di Mario | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 2 | DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor显示文摘AIM: To determine the DNA binding activity and protein levels of the Ku70/80 heterodimer, the functional mediator of the NHEJ activity, in human colorectal carcinogenesis.METHODS: The Ku70/80 DNA-binding activity was determined by electrophoretic mobility shift assays in 20 colon adenoma and 15 colorectal cancer samples as well as matched normal colonic tissues. Nuclear and cytoplasmic protein expression was determined by immunohistochemistry and Western blot analysis.RESULTS: A statistically significant difference was found in both adenomas and carcinomas as compared to matched normal colonic mucosa (P<0.00). However,changes in binding activity were not homogenous with approximately 50% of the tumors showing a clear increase in the binding activity, 30% displaying a modest increase and 15% showing a decrease of the activity.Tumors, with increased DNA-binding activity, also showed a statistically significant increase in Ku70 and Ku86nuclear expression, as determined by Western blot and immunohistochemical analyses (P<0.001). Cytoplasmic protein expression was found in pathological samples,but not in normal tissues either from tumor patients or from healthy subjects.CONCLUSION: Overall, our DNA-binding activity and protein level are consistent with a substantial activation of the NHEJ pathway in colorectal tumors. Since the NHEJ is an error prone mechanism, its abnormal activation can result in chromosomal instability and ultimately lead to tumorigenesis. | Paola Mazzarelli Paola Parrella Davide Seripa Emanuela Signori Giuseppe Perrone Carla Rabitti Domenico Borzomati Armando Gabbrielli Maria Giovanna Matera Carolina Gravina Marco Caricato Maria Luana Poeta Monica Rinaldi Sergio Valeri Roberto Coppola Vito Michele Fazio | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 3 | Hydroxytryptamine transporter gene-linked polymorphic region(5HTTLPR)is associated with delusions in Alzheimer’s disease显示文摘Background:Serotoninergic pathways underlying delusion symptoms in Alzheimer’s disease(AD)have not been fully clarified.5-Hydroxytryptamine transporter gene-linked polymorphic region(5-HTTLPR)is a variable number tandem repeats in the promoter region of serotonin transporter encoding-gene affecting transcription.Methods:We investigated the association of 5-HTTLPR with delusions in a total of 257 consecutive patients clinically diagnosed as AD according to the National Institute on Aging-Alzheimer’s Association criteria.All participants underwent a comprehensive evaluation with a standardized comprehensive geriatric assessment and Neuropsychiatric Inventory.Results:Delusion symptoms were observed in 171 patients(66.54%).In respect to AD patients without delusions,AD patients with delusions showed a low prevalence of S-plus carriers(5-HTTLPR-L/S+5-HTTLPR-S/S genotypes)[p<0.001;odds ratio(OR)=0.240,95% confidence interval(CI)=0.121–0.471].Logistic regression analysis adjusted for the apolipoprotein E polymorphism showed that in AD patients with delusions the presence of an 5-HTTLPR-S allele may reduce disease duration(p=0.005;OR=0.680,95% CI=0.522–0.886)and increase aberrant motor activity(p=0.013;OR=2.257,95% CI=1.195–4.260).The present findings suggested that 5-HTTLPR might be associated with delusions in AD.S-plus carriers might be associated with protective effect against delusions in AD.Conclusions:More studies on wider samples of high selected demented patients are needed to confirm our results.However,the present findings suggested that a genetic factor related to serotonin metabolism might exert a protective role on the clinical expression of neuropsychiatric clusters in AD with important implications regarding mechanisms underlying delusions and their possible treatment across the AD and dementia spectrum. | Grazia D’Onofrio Francesco Panza Daniele Sancarlo Michele Lauriola Mariangela P.Dagostino Giulia Paroni Madia Lozupone Antonio Mangiacotti Paola Bisceglia Carolina Gravina Maria Urbano Filomena Addante Francesco Paris Leandro Cascavilla Antonio Greco Davide Seripa | 2019 | Translational Neurodegeneration2019，8，1： | 2 |
| 4 | Polymorphism C in the serotonin transporter gene in depres- sion-free elderly patients with vascular dementia 显示文摘 | SERIPA D MATERA M G D'ONOFRIO G | 2010 | Dement Geriatr Cogn Disord2010，29，5： | 1 |
| 5 | The complex interaction between ApoE promoter and AD : an Italian case-control study 显示文摘 | Bizzarro A Seripa D Acciarri A | 2009 | Eur J Hum Genet2009，17，7： | 1 |
| 6 | Alcohol intake in the elderly affects risk of cognitive decline and dementia显示文摘 | Panza F Frisardi V Seripa D | 2012 | Am J Alzheimers Dis Other Demen2012，27，5： | 1 |
| 7 | Prevalence of apolipoprotein E alleles in healthy subjects and survivors of ischemic stroke:an Italian Case-control Study显示文摘 | Margaglion M Seripa D Gravina C | 1998 | Stroke1998，29，2： | 1 |
| 8 | Mediterranean diet in prede- mentia and dementia syndromes 显示文摘 | Solfrizzi V Frisardi V Seripa D | 2011 | Current Alzheimer research2011，8，5： | 1 |
| 9 | Role of the serotonin transporter gene locus in the response to SSRI treatment of major depressive dis- order in late life显示文摘 | Seripa D Pilotto A Paroni G | 2015 | J Psychopharmacol2015，29，15： | 1 |
| 10 | Age-related hearing impairment and frailty in Alzheimer's disease: interconnected associations and mechanisms 显示文摘 | Panza F Solfrizzi V Seripa D | 2015 | Frontiers in Aging Neuroscience2015，7，： | 1 |
| 11 | The Genetics of theHuman APOE Polymorphism显示文摘 | Seripa D DOnofrio G Panza F | 2011 | Rejuvenation Res2011，14，： | 1 |
| 12 | Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism显示文摘 | Matera MG Andrea BSc | 2004 | Neurology2004，62，： | 1 |
| 13 | Mutations of the D310 mito- chondrial mononucleotide repeat in primary tumors and cytological specimens显示文摘 | Parrella P Seripa D Matera MG | 2003 | Cancer Lett2003，190，1： | 1 |
| 14 | Sensitive detection of transitional cell carcinoma of the bladder by microsatellite analysis of cells exfoliated in urine显示文摘 | Parrella P Gallucci M | 2001 | Int J Cancer2001，5，6： | 1 |
| 15 | Oxidative balance, homocysteine, and uric acid levels in older patients with Late Onset Alzheimer's Disease or Vascular Dementia显示文摘 | Cervellati C Romani A Seripa D | 2014 | J Neurol Sci2014，337，12： | 1 |
| 16 | Metabolic-cognitive syn- drome:a cross-talk between metabolic syndrome and Alzheimer' s disease 显示文摘 | Frisardi V Solfrizzi V Seripa D | 2010 | Ageing Res Rev2010，9，4： | 1 |
| 17 | Associa-tion analysis of GRIN2B, encoding N-methyl-D-aspar-tate receptor 2B subunit, and Alzheimers disease 显示文摘 | Seripa D Matera M G Franceschi M | 2008 | Dement Geriatr Cogn Disord2008，25，3： | 1 |
| 18 | Metabolic -cognitive syndrome: A cross -talk between metabolic syndrome and alzheimer's disease显示文摘 | Frisardi V Solfrizzi V Seripa 0 | 2010 | Ageing Research Reviews2010，9，4： | 1 |
| 19 | Apolipoprotein E genotypes in hospitalized elderly patients with vascular dementia显示文摘 | Orsitto G Seripa D Panza F | 2007 | Dement Geriatr Cogn Disord2007，23，： | 1 |
| 20 | Mutations of the D310 mitochondrial mononucleotide repeat in primary tumors and cytological specimens显示文摘 | PARRELLA P SERIPA D MATERA M G | 2003 | Cancer Lett2003，190，1： | 1 |
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