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| 1 | Carbonic anhydrase enzymes Ⅱ, Ⅶ, Ⅸ and Ⅻ in colorectal carcinomas显示文摘AIM To investigate expression of four alpha-carbonic anhydrases(CAs) in colorectal carcinomas(CRC) and compare the results with patients' survival.METHODS Colorectal carcinoma samples from 539 CRC patients and control tissues were arranged as tissue microarrays and analyzed with antibodies against CA Ⅱ, CA Ⅶ, CA Ⅸ, and CA Ⅻ. Intensity and extent of staining were both scored from 0 to 3 in each sample. These enzyme expression levels were then correlated to patients' survival and clinicopathological parameters, which were tumor differentiation grade and stage, site of tumor, patients' age, and gender. Kaplan-Meier analysis and Cox regression hazard ratio model were used to analyze survival data. RESULTS CA Ⅱ and CA Ⅻ staining intensities correlated with patients' survival in that higher expression indicated poorer prognosis. In Cox regression analysis one unit increase in the CA Ⅱ intensity increased the hazard ratio to 1.19 fold(CI: 1.04-1.37, P = 0.009). A significant correlation was also found when comparing CA Ⅻ staining intensity with survival of CRC patients(HR = 1.18, 95%CI: 1.01-1.38, P = 0.036). The extent of CA Ⅻ immunostaining did not correlate to the patients' survival(P = 0.242, Kaplan-Meier analysis). A significant interaction between age group and extent of the CA Ⅱ staining was found. Increased extent of CA Ⅱ had a significant hazard ratio among patients 65 years and older(1.42, 95%CI: 1.16-1.73, P = 0.0006). No correlations were found between CA Ⅶ(intensity P = 0.566, extent P = 0.495, Kaplan-Meier analysis), or CA Ⅸ(intensity P = 0.879, extent P = 0.315, KaplanMeier analysis) immunostaining results and survival, or the other parameters. CONCLUSION The present findings indicate that CA Ⅱ and CA Ⅻ could be useful in predicting survival in CRC. | Pia Viikil? Antti J Kivel? Harri Mustonen Selja Koskensalo Abdul Waheed William S Sly Jaromir Pastorek Silvia Pastorekova Seppo Parkkila Caj Haglund | 2016 | World Journal of Gastroenterology2016，22，36： | 3 |
| 2 | Association of Helicobacter pylori IgA antibodies with the risk of peptic ulcer disease and gastric cancer显示文摘AIM: To compare the prevalence of Helicobacter pylori (Hpylori) IgG and IgA antibodies between adult subjects,with defined gastric diseases, nondefined gastric disorders and those representing the population.METHODS: Data on H pylori IgG and IgA antibodies,determined by enzyme immunoassay, were analyzed in 3 252 subjects with DGD including 482 patients with gastric ulcer, 882 patients with duodenal ulcer, 1 525patients with chronic gastritis only and 363 subjects with subsequent gastric cancer, 19 145 patients with NoDg and4 854 POPUL subjects. The age-adjusted prevalences were calculated for 1- and 20-year age cohorts.RESULTS: The prevalences of IgG antibodies were equally high (89-96%) in all 20-year age cohorts of the DGD groups, whereas the prevalences of IgG antibodies were lower and increased by age in the POPUL and NoDg groups. The prevalences of IgA antibodies were also higher in the DGD groups; among them CA (84-89%) and GU groups (78-91%) showed significantly higher prevalences than DU (68-77%) and CG patients (59-74%) (OR 2.49, 95%CI 1.86-3.34 between the GU and DU groups). In the CA, GU, and DU groups, the IgA prevalences showed only minor variation according to age, while they increased by age in the CG, POPUL, and NoDg groups (P≤0.0001). The IgA response, but not the IgG response, was associated with an increased risk of CA (OR 2.41, 95%CI 1.79-3.53) and GU (OR 2.57,95%CI 1.95-3.39) in comparison with CG patients.CONCLUSION: An IgA antibody response during H pylori infection is significantly more common in CA and GU patients as compared with CG patients. | Timo U Kosunen Kari Seppl Seppo Sarna Arpo Aromaa Paul Knekt Jarmo Virtamo Anniina Salomaa-Rsnen Hilpi Rautelin | 2005 | World Journal of Gastroenterology2005，11，43： | 3 |
| 3 | Delayless recursive differ- entiator with efficient noise attenuation for control instrumentation 显示文摘 | VALIVIITA S SEPPO OVASKA J | 1998 | Signal Processing1998，69，3： | 1 |
| 4 | Regular Aspirin-Use Preceding the Onset of Primary Intracerebral Hemorrhage Is an Independent Predictor for Death显示文摘 | Pertti S Mikko A Seppo J | 2006 | Stroke2006，37，1： | 1 |
| 5 | Reversible surface binding of cadmium and lead by lactic acid and bifidobacteria显示文摘 | Teemu H Seppo S Jussi M | 2008 | International journal of food microbiology2008，125，2： | 1 |
| 6 | Hyperuricemia is a strong predictor of stroke in patients with non-insulin-dependent diabetes mellitus显示文摘 | Seppo Lehto MD Earl S Ford S Jay Smith | 1998 | Stroke1998，29，： | 1 |
| 7 | D dimer as an independent predictor for poor outcome after aneurysmal subarachnoid hemorrhage 显示文摘 | Seppo J Jari S | 2006 | Stroke2006，37，： | 1 |
| 8 | Regular aspirin-use preceding the on- set of primary intracerebral hemorrhage is an independent predic- tor for death显示文摘 | Pertti S Mikko A Seppo J | 2009 | Stroke2009，29，5： | 1 |
| 9 | Performance of bifidobacteria in oat-based media显示文摘 | Riikka L Seppo S Yoshimi B | 2003 | Food Microbiology2003，83，： | 1 |
| 10 | Protection of rainbow trout(Oncorhynchus mykiss)from furunculosis by Lactobacillus rhamnosus显示文摘 | SAMI N ARTHUR O SEPPO S et a1 | 2001 | Aquaculture2001，198，： | 1 |
| 11 | The role of the intestinal microflora for the development of the immune system in early childhood显示文摘 | Arthur O Erika I Seppo S | 2002 | Eu- rop J Nutr2002，41，1： | 1 |
| 12 | Adhesion of some probiotic and dairy Lactobacillus strains to Caco-2 cell cultures显示文摘 | Elina M T Seppo J S | 1998 | Int J Food Microbiol1998，41，： | 1 |
| 13 | In vitro analysis of probiotic strain combinations to inhibit pathogen adhesion to human intestinal mucus显示文摘 | CARMEN COLLADO M JUSSI M SEPPO S | 2007 | Food Res Intern2007，40，5： | 1 |
| 14 | PCDD,PCDF,and PCB concentrations in human milk from two areas in Finland显示文摘 | TERTTU V SEPPO S JOUNI J J | 1997 | Chemosphere1997，34，12： | 1 |
| 15 | Adhersion of two Lactobacillus strains,one lactoeoceus and one propionibacterium strain to cultured human intestinal Caco-2 cell line显示文摘 | Elina M LEHTO Seppo S | 1997 | Bioscience Mieroflora1997，16，1： | 1 |
| 16 | Probiotic bacteria in the management of atopic disease:underscoring the importance of viability显示文摘 | Pirkka K Seppo S Erika I | 2003 | Journal of Pediatric Gastroenterology and Nutrition2003，36，： | 1 |
| 17 | Fermentation of carrot juice by probiotics:viability and preservation of adhesion显示文摘 | MARJA T SEPPO S ARTHUR C O | 2013 | Int J Biol Wellness Industries2013，2，1： | 1 |
| 18 | Adhersion of two lactobacillus strains, one lactococcus and one propionibacterium strain to cultured human intestinal Caco-2 cell line 显示文摘 | LEHTO Seppo S | 1997 | Bioscience Microflora1997，16，1： | 1 |
| 19 | In vitro analysis of probiotic strain combinations to inhibit pathogen adhesion to human intestinal- mucus 显示文摘 | CARMEN COLLADO M JUSSIM SEPPO S | 2007 | Food Res Intern2007，40，5： | 1 |
| 20 | Modulation of humoral immune response through probiotic intake显示文摘 | T Elina A Heikki S Seppo | 2000 | Immunology and Medical Microbiology2000，29，1： | 1 |
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