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| 1 | Development and organisation of gonadal steroidogenesis in bony fishes - A review显示文摘Gonadal steroidogenesis is pivotal to synchronize various reproductive stages including sexual development,growth and maturation.In all vertebrates including teleost,steroidogenesis is triggered by the mobilization of cholesterol by steroidogenic acute regulatory protein from outer to inner mitochondrial membrane.Thereafter,the entire process occurs in endoplasmic reticulum or mitochondria wherein various steroidogenic enzyme genes play a crucial role.The onset of steroidogenesis during sexual development in teleost is essentially regulated by differential expression of several transcription as well as steroidogenesis-related factors.More specifically,the role of dmrt,sox9,sox3,other sox forms,ad4bp/sf-1,wt-1,foxl2,ftz-f1,gata4,gsdf,Activator protein-1,fgfs and growth factors and steroidogenic enzymes such as cytochrome P450aromatase(cyp19a1),hydroxysteroid 3β-dehydrogenase(hsd3b),hydroxysteroid 17β-dehydrogenase(hsd17b)have been well characterised.Recently,the role of pax2,THO complex(thoc),pentraxin(ptx)and few signalling molecules like wnt4/5 regulating teleostean steroidogenesis has been reported.In females,cyp19a1 appears to be critical as it converts androgens to estrogens during ovarian differentiation which suggests that estradiol-17βis indispensable for the event.Unlike females,males do not depend on testosterone for testicular determination,yet has a major role along with 11-ketotestosterone in testicular development and growth when compared to early testicular differentiation.In males,onset of sex determining or testis-related genes seems most essential.Considering these,the regulation of steroidogenesis is virtually critical at later stages.In view of this,several steroidogenic motifs pertaining to transcriptional regulation have been analysed in teleost,yet far below than the reports on mammals.In this context,the regulatory influence on HHG axis plays a critical role in teleost.Further,multiple gonadotropin-releasing hormones and duality of gonadotropins play a differential role in gonadal function.As for steroidogenic pathway,the synthesis of sex steroids predominantly usesΔ4,however,Δ5 pathway was also evident.The next aspect is shift in steroidogenesis that usually occurs in the maturing follicles during final oocyte maturation,yet such a mechanism is not clear in males.The review highlights the interactions of steroidogenic enzyme gene regulation in terms of HHG axis and other important transcription factors that are involved in the regulatory pathways as well as the influence of environmental and dietary factors by comparing both sexes to present a holistic view on steroidogenesis onset and organisation during gametogenesis in teleost. | Swathi Tenugu Akanksha Pranoty Sajwan-Khatri Mamta Balasubramanian Senthilkumaran | 2021 | Aquaculture and Fisheries2021，6，3： | 2 |
| 2 | Effect of copper nanoparticles exposure in the physiology of the common carp(Cyprinus carpio):Biochemical,histological and proteomic approaches显示文摘Copper nanoparticles(Cu-NPs)are serious water pollutants but their impact in teleosts performance remains poorly understood.In the present study,we have exposed juvenile carps(Cyprinus carpio),a freshwater teleost edible in India to two different doses(20 and 100 mg/L)of Cu-NPs for seven days.The doses selected were eco-relevant considering the contamination levels of certain water resources.The results indicated that the activity oxidative stress enzymes catalase,superoxide dismutase,and glutathione-S-transferase were significantly increased in the kidney,liver and gills of the treated groups when compared to control.Histological analysis revealed that after exposure,disruption of the secondary lamellae of gills,liver damage with pyknotic nuclei and structural disarray of the kidney occurred.Proteomic analysis of the liver showed down-regulation of several proteins including the ferritin heavy chain,rho guanine nucleotide exchange factor 17-like,cytoglobin-1 and up-regulation of diphosphomevalonate decarboxylase and selenide&water dikinase-1.Taken together,the results of suggest that short-term exposure of juvenile carp to Cu-NPs causes oxidative stress and impart serious deleterious effects in the tissues which may affect fish growth and development. | Yugantak Raj Gupta Durai Sellegounder Monica Kannan Seetharam Deepa Balasubramanian Senthilkumaran Yaraguntappa Basavaraju | 2016 | Aquaculture and Fisheries2016，1，1： | 2 |
| 3 | Ovarian carbonyl reductase-like 20 beta-hydroxysteroid dehydrogenase shows distinct surge in messenger RNA expression during natural and gonadotropin-induced meiotic maturation in Nile tilaDia显示文摘 | Senthilkumaran B Sudhakumari CC Chang XT | 2002 | Biol Reprod2002，67，： | 1 |
| 4 | Cerebral fat embolism in a non-head-injured trauma victim:a diagnostic dilemma显示文摘 | Senthilkumaran S Balamurugan N Suresh P | 2012 | J Neurosci Rural Pract2012，10，3： | 1 |
| 5 | Effect of primary spherical aberration on high-numerical-aperture focusing of a Laguerre - Gaussian beam显示文摘 | SINGH R K SENTHILKUMARAN P SINGH K | 2008 | JOSA A2008，25，6： | 1 |
| 6 | A shift in steroidogenesis occurring in ovarian follicles prior to oocyte maturation 显示文摘 | Senthilkumaran B Yoshikuni M Nagahama Y | 2004 | Mol Cell Endocrinol2004，215，： | 1 |
| 7 | Ontogenic expression patterns of several nuclear receptors and cytochrome P450 aromatases in brain and gonads of the Nile tilapia Oreochromis nilotic-us suggests their involvement in sex differentiation显示文摘 | Sudhakumari C C Senthilkumaran B Kobayashi T | | 0，，2： | 1 |
| 8 | Cloning, expression and characterization of three types of 17显示文摘 | Zhou L Y Wang D S Senthilkumaran B | 2005 | Journal of Molecular Endo- crinology2005，35，： | 1 |
| 9 | Optical transfer function of an optical system with a vortex phase mask in the presence of primary aberrations显示文摘 | SINGH R K SENTHILKUMARAN P SINGH K | 2010 | Optics & Laser Technoloa2010，42，1： | 1 |
| 10 | Cloning and differential expression pattern of vasa in the developing and recrudescing gonads of catfish,Clarias gariepinus显示文摘 | Kavarthapu Raghuveer Balasubramanian Senthilkumaran | 2010 | Comparative Biochemistry and Physiology Part A2010，157，： | 1 |
| 11 | Two types of aromatase with different encoding genes, tissue distribution and developmental expression in Nile tilapia (Oreochromis niloticus ) 显示文摘 | CHANG X KOBAYASHI T SENTHILKUMARAN B | 2005 | General and Comparative Endocrinology2005，141，2： | 1 |
| 12 | Edge Detection Techniques for Image Segmentation A Survey of Soft Computing Ap- proaches显示文摘 | Senthilkumaran N Rajesh R | 2009 | International Journal of Recent Trends in Engi- neering2009，1，2： | 1 |
| 13 | Use of a vascular access port for the measurement of pulsatile luteinizing hor- mone in old broiler breeders 显示文摘 | Senthilkumaran C Peterson S Taylor B | 2006 | Poult Sci2006，85，9： | 1 |
| 14 | Prolonged sedation relatedto erythromycin and midazolam interaction: a word of caution显示文摘 | Senthilkumaran S Subramanian P T | 2011 | Indian Pediatr2011，48，11： | 1 |
| 15 | Co-administration of C-Phycocyanin ameliorates thioacetamide-induced hepatic encephalopathy in Wistar rats显示文摘 | K.V. Sathyasaikumar I. Swapna P.V.B. Reddy Ch.R.K. Murthy K.R. Roy A. Dutta Gupta B. Senthilkumaran P. Reddanna | 2006 | Journal of the Neurological Sciences2006，，： | 1 |
| 16 | A shift in steroidogenesis occurring in ovarian follicles prior to oocyte maturation 显示文摘 | Senthilkumaran B Yoshikuni M Nagahama Y | 2004 | Molecular and cellular Endocrinology2004，215，1： | 1 |
| 17 | Early congestion detection and adaptive routing in MANET显示文摘 | Senthilkumaran T Sankaranarayanan V | 2011 | Egyptian Informatics Journal2011，12，3： | 1 |
| 18 | Molecular cloning of two isoforms of 11beta-hydroxylase and their expressions in the Nile tilapia, Oreochromis niloticus 显示文摘 | Zhang W L Zhou L Y Senthilkumaran B | 2009 | General and Comparative Endocrinology2009，165，1： | 1 |
| 19 | BLUE-Based Channel Estimation Technique for Amplify and Forward Wireless Relay Networks显示文摘 | PREMKUMAR M SENTHILKUMARAN V N THIRVVENGADAM S J | 2012 | ETRI Journal2012，34，4： | 1 |
| 20 | Single-slit diffraction of an optical beam with phase singularity 显示文摘 | Devinder Pal Ghai P Senthilkumaran R S Sirohi | 2009 | Optics and Lasers in Engineering2009，35，23： | 1 |
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