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| 1 | 考虑湿化效应的堆石料Gudehus-Bauer亚塑性模型应用研究显示文摘在扼要分析堆石料主要力学特性的基础上,在亚塑性理论框架内,采用扩展的Gudehus-Bauer亚塑性模型对堆石料因含水率发生变化引起的湿化行为进行建模预测。扩展模型除能考虑含水率对颗粒硬度的影响外,还能反映土体密实度、应力状态和含水率等对堆石料非线性和非弹性变形的影响。将该模型应用于心墙坝初次蓄水时应力变形的亚塑性计算分析中。结果表明,扩展模型能较合理地反映心墙堆石坝的湿化变形规律。 | 岑威钧 Erich Bauer Sendy F.Tantono | 2009 | 岩土力学2009，30，12： | 8 |
| 2 | Hepatitis B and liver transplantation: Molecular and clinical features that influence recurrence and outcome显示文摘Hepatitis B virus(HBV) continues to be a major cause of morbidity and mortality worldwide. It is estimated that about 350 million people throughout the world are chronically infected with HBV. Some of these people will develop hepatic cirrhosis with decompensation and/or hepatocellular carcinoma. For such patients, liver transplantation may be the only hope for cure or real improvement in quality and quantity of life. Formerly, due to rapidity of recurrence of HBV infection after liver transplantation, usually rapidly progressive, liver transplantation was considered to be contraindicated. This changed dramatically following the demonstration that hepatitis B immune globulin(HBIG), could prevent recurrent HBV infection. HBIG has been the standard of care for the past two decades or so. Recently, with the advent of highly active inhibitors of the ribose nucleic acid polymerase of HBV(entecavir, tenofovir), there has been growing evidence that HBIG needs to be given for shorter lengths of time; indeed, it may no longer be necessary at all. In this review, we describe genetic variants of HBV and past, present, and future prophylaxis of HBV infection during and after liver transplantation. We have reviewed the extant medical literature on the subject of infection with the HBV, placing particular emphasis upon the prevention and treatment of recurrent HBV during and after liver transplantation. For the review, we searched PubMed for all papers on the subject of 'hepatitis B virus AND liver transplantation'. We describe some of the more clinically relevant and important genetic variations in the HBV. We also describe current practices at our medical centers, provide a summary and analysis of comparative costs for alternative strategies for prevention of recurrent HBV, and pose important still unanswered questions that are in need of answers during the next decade or two. We conclude that it is now rational and cost-effective to decrease and, perhaps, cease altogether, the routine use of HBIG during and following liver transplantation for HBV infection. Here we propose an individualized prophylaxis regimen, based on an integrated approach and risk-assessment. | Tahereh Ghaziani Hossein Sendi Saeid Shahraz Philippe Zamor Herbert L Bonkovsky | 2014 | World Journal of Gastroenterology2014，20，39： | 7 |
| 3 | Overview of recent advances in metastatic triple negative breast cancer显示文摘Metastatic triple negative breast cancer(TNBC)has an aggressive phenotype with a predilection for visceral organs and brain.Best responses to chemotherapy are predominately in the first line.Recent studies have demonstrated improved progression free survival with the combination of atezolizumab/pembrolizumab and chemotherapy in programmed death-ligand 1 positive metastatic TNBC.However,a recent trial in a similar population showed no benefit for atezolizumab and paclitaxel which led to a Food and Drug Administration alert.Two phase III trials(OLYMPIAD and BROCADE3)demonstrated a benefit in progression free survival(PFS)but not overall survival in patients with BRCAassociated metastatic TNBC treated with Olaparib or Talazoparib respectively.For those treated with Talazoparib,the time to deterioration in health related-quality of life was also longer compared to chemotherapy.The BROCADE3 trial demonstrated that the combination of a platinum and veliparib increased PFS in first-line metastatic TNBC but at the cost of increased toxicity.There are no headto-head comparisons of a poly(adenosine diphosphate-ribose)polymerase inhibitors(PARPi)and platinums.There are unanswered questions regarding the role of PARPi maintenance after platinum therapy as is standard of care in BRCAassociated ovarian cancer.Other areas of therapeutic interest include targeting aberrations in the phosphoinositide 3-kinase pathway,protein kinase B,mammalian target of rapamycin or utilising antibody drug conjugates.This review focusses on recent and emerging therapeutic options in metastatic TNBC.We searched PubMed,clinicaltrials.gov and recent international meetings from American Society of Clinical Oncology,San Antonio Breast Cancer Conference and the European Society of Medical Oncology. | David O'Reilly Maha Al Sendi Catherine M Kelly | 2021 | World Journal of Clinical Oncology2021，12，3： | 5 |
| 4 | Legalon-SIL downregulates HCV core and NS5A in human hepatocytes expressing full-length HCV显示文摘AIM: To determine the effect of Legalon-SIL (LS) on hepatitis C virus (HCV) core and NS5A expression and on heme oxygenase-1 (HMOX-1) and its transcriptional regulators in human hepatoma cells expressing full length HCV genotype 1b. METHODS: CON1 cells were treated with 50 μmol/L or 200 μmol/L LS. Cells were harvested after 2, 6 and 24 h. HCV RNA and protein levels were determined by quantitative real-time polymerase chain reaction and Western blotting, respectively. RESULTS: HCV RNA (core and NS5A regions) wasdecreased after 6 h with LS 200 μmol/L (P < 0.05). Both 50 and 200 μmol/L LS decreased HCV RNA levels [core region (by 55% and 88%, respectively) and NS5A region (by 62% and 87%, respectively) after 24 h compared with vehicle (dimethyl sulphoxide) control (P < 0.01). Similarly HCV core and NS5A protein were decreased (by 85%, P < 0.01 and by 65%, P < 0.05, respectively) by LS 200 μmol/L. Bach1 and HMOX-1 RNA were also downregulated by LS treatment (P < 0.01), while Nrf2 protein was increased (P < 0.05).CONCLUSION: Our results demonstrate that treatment with LS downregulates HCV core and NS5A expression in CON1 cells which express full length HCV genotype 1b, and suggests that LS may prove to be a valuable alternative or adjunctive therapy for the treatment of HCV infection. | Marjan Mehrab-Mohseni Hossein Sendi Nury Steuerwald Sriparna Ghosh Laura W Schrum Herbert L Bonkovsky | 2011 | World Journal of Gastroenterology2011，17，13： | 3 |
| 5 | Shopping online and/or in-store? A structural equation model of the relationships between e-shopping and in-store shopping显示文摘 | Sendy Farag Tim Schwanen Martin Dijst Jan Faber | 2006 | Transportation Research Part A2006，，2： | 2 |
| 6 | 高表达抗人TNF-α人-鼠嵌合抗体细胞株的建立及其表达产物的分析显示文摘目的建立高表达抗人TNF-α人-鼠嵌合抗体的工程细胞株。方法将构建的抗人TNF-α人-鼠嵌合抗体基因真核表达载体转染CHO细胞,并采用DHFR/MTX基因扩增策略,经反复加压和克隆筛选,提高抗体的表达量。用ELISA、Westernblot和体外中和试验分析比较抗人TNF-α人-鼠嵌合抗体与鼠亲本单抗的特性。结果获得的表达抗人TNF-α嵌合抗体的转染细胞系2F5,在静止培养4d后工程抗体的表达量约80mg/L。所表达的工程抗体优于鼠亲本单抗F7/2,并具有良好的特异性和中和活性,其相对亲和力约为2.1×10-10mol/L。结论已成功建立了高表达的嵌合抗体工程细胞株,其抗体具有潜在的临床应用前景。 | 聂艳桃 何太平 谢荣麟 葛永红 容新宗 陶昆蓉 刘宇虹 王琰 Sendi Montanie Vladka Curin-Serbec | 2006 | 中国生物制品学杂志2006，19，6： | 2 |
| 7 | Isoniazid prophylaxis for tuberculosis in HIV infection: a meta-analysis of randomized controlled trials显示文摘 | Bucher HC Griffith LE Guyatt GH Sudre P Naef M Sendi P Battegay M | 1999 | AIDS1999，13，： | 1 |
| 8 | Dynamics of serum procalcitonin in patients after major neurosurgery 显示文摘 | Laifer G Wasner M Sendi P | 2005 | Clin M icrobiol Infect2005，11，8： | 1 |
| 9 | Cost-effectiveness of extended venous thromboembolism prophylaxis with fondaparinux in hip surgery patients显示文摘 | Bischof M Leuppi JD Sendi P | 2006 | Expert Rev Pharmacoecon Outcomes Res2006，6，2： | 1 |
| 10 | TI764G1766 core pror rooter double mutants are restricted to hepatitis B virus strains with an A1757 and are common in genotype D显示文摘 | Sendi H Mehrzb--Mohseni M Zali MR | 2005 | J Gen Virol2005，86，9： | 1 |
| 11 | tests todetect and characterize antibiotic resistance mechanisms inEnterobacteriaceae显示文摘 | Lupo A Papp-Wallace KM Sendi P Non-phenotypic | 2013 | Diagn Microbiol Infect Dis2013，77，3： | 1 |
| 12 | Comparison of periapical radiography and limited cone-beam computed tomography in mandibular molars for analysis of anatomical landmarks before apical surgery 显示文摘 | Bornstein MM Lauber R Sendi P | 2011 | J Endod2011，37，2： | 1 |
| 13 | Morphology of the naso-palatine canal and dental implant surgery : a radiographic analysis of100 consecutive patients using limited cone-beam computed tomo-graphy 显示文摘 | Bomstein MM Balsiger R Sendi P | 2011 | Clin Oral Implants Res2011，22，3： | 1 |
| 14 | Immediate loading of two unsplinted mandibular implants in edentulous patients with an implant-retained overdenture: an observational study over two years显示文摘 | Büttel AE Gratwohl DA Sendi P | 2012 | Schweiz Monatsschr Zahnmed2012，122，5： | 1 |
| 15 | Hepatitis C,porphyria cutanea tarda and liver iron:an update显示文摘 | Ryan Caballes F Sendi H Bonkovsky HL | 2012 | Liver Int2012，32，6： | 1 |
| 16 | Spinal epidural abscess in clinical pracitce显示文摘 | Sendi P Bregenzer T Zimmerli W | 2008 | QJM2008，101，： | 1 |
| 17 | Comparison of periapical radiography and limited cone-beam computed tomography in mandibular molars for analysis of anatomical landmarks before apical surgery显示文摘 | Bornstein MM Lauber R Sendi P | 2011 | J Endod2011，37，2： | 1 |
| 18 | Dual RolMolecular Pathogenee of miR-122 in sis of Viral Hepatitis显示文摘 | Sendi H | | 0，，05： | 1 |
| 19 | Tile effects of BmNPV on biochemical changes in primary cultures of Bombyx mori embryonic tissue显示文摘 | Matindoost L Sendi J J Soleimanjahi H | 2008 | In Vitro Cell Dev-An2008，44，3： | 1 |
| 20 | Spinal epidural abscess in clinical practice显示文摘 | Sendi P Bregenzer T Zimmerli W | 2008 | QJM2008，101，1： | 1 |
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