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| 1 | New vacuum solar telescope and observations with high resolution显示文摘The New Vacuum Solar Telescope(NVST) is a one meter vacuum solar telescope that aims to observe fine structures on the Sun. The main goals of NVST are high resolution imaging and spectral observations, including measurements of the solar magnetic field. NVST is the primary ground-based facility used by the Chinese solar research community in this solar cycle. It is located by Fuxian Lake in southwest China, where the seeing is good enough to perform high resolution observations. We first introduce the general conditions at the Fuxian Solar Observatory and the primary science cases of NVST. Then, the basic structures of this telescope and instruments are described in detail. Finally, some typical high resolution data of the solar photosphere and chromosphere are also shown. | Zhong Liu Jun Xu Bo-Zhong Gu Sen Wang Jian-Qi You Long-Xiang Shen Ru-Wei Lu Zhen-Yu Jin Lin-Fei Chen Ke Lou Zhi Li Guang-Qian Liu Zhi Xu Chang-Hui Rao Qi-Qian Hu Ru-Feng Li Hao-Wen Fu Feng Wang Men-Xian Bao Ming-Chan Wu Bo-Rong Zhang | 2014 | Research in Astronomy and Astrophysics2014，14，6： | 37 |
| 2 | Electroacupuncture activates enteric glial cells and protects the gut barrier in hemorrhaged rats显示文摘AIM:To investigate whether electroacupuncture ST36 activates enteric glial cells,and alleviates gut inflammation and barrier dysfunction following hemorrhagic shock.METHODS:Sprague-Dawley rats were subjected to approximately 45% total blood loss and randomly divided into seven groups:(1) sham:cannulation,but no hemorrhage;(2) subjected to hemorrhagic shock(HS);(3) electroacupuncture(EA) ST36 after hemorrhage;(4) vagotomy(VGX)/EA:VGX before hemorrhage,then EA ST36;(5) VGX:VGX before hemorrhage;(6) a-bungarotoxin(BGT)/EA:intraperitoneal injection of a-BGT before hemorrhage,then EA ST36; and(7) a-BGT group:a-BGT injection before hemorrhage.Morphological changes in enteric glial cells(EGCs) were observed by immunofluorescence,and glial fibrillary acidic protein(GFAP; a protein marker of enteric glial activation) was evaluated using reverse transcriptase polymerase chain reaction and western blot analysis.Intestinal cytokine levels,gut permeability to 4-k Da fluorescein isothiocyanate(FITC)-dextran,and the expression and distribution of tight junction protein zona occludens(ZO)-1 were also determined.RESULTS:EGCs were distorted following hemorrhage and showed morphological abnormalities.EA ST36 attenuated the morphological changes in EGCs at 6 h,as compared with the VGX,a-BGT and HS groups.EA ST36 increased GFAP expression to a greater degree than in the other groups.EA ST36 decreased intestinal permeability to FITC-dextran(760.5 ± 96.43 ng/m L vs 2466.7 ± 131.60 ng/m L,P < 0.05) and preserved ZO-1 protein expression and localization at 6 h afterhemorrhage compared with the HS group.However,abdominal VGX and a-BGT treatment weakened or eliminated the effects of EA ST36.EA ST36 reduced tumor necrosis factor-a levels in intestinal homogenates after blood loss,while vagotomy or intraperitoneal injection of a-BGT before EA ST36 abolished its antiinflammatory effects.CONCLUSION:EA ST36 attenuates hemorrhageinduced intestinal inflammatory insult,and protects the intestinal barrier integrity,partly via activation of EGCs. | Sen Hu Zeng-Kai Zhao Rui Liu Hai-Bin Wang Chun-Yu Gu Hong-Min Luo Huan Wang Ming-Hua Du Yi Lv Xian Shi | 2015 | World Journal of Gastroenterology2015，21，5： | 15 |
| 3 | Dual-lens beam compression for optical coupling in superconducting nanowire single-photon detectors显示文摘The optical coupling of superconducting nanowire single-photon detectors(SNSPDs) has always been restricted to a single-mode fiber for a limited detection area. In this study, for enhancing photon coupling, a dual-lens system operating at 2.2 K was used to compress the beam size on the basis of the Gaussian beam theory and geometric approximation. A magnification of approximately 0.3 was obtained, and a focused spot with diameter of approximately 10 lm was measured from a multimode fiber. Assisted with the compressed beam, a system efficiency of 55 %(1550 nm) was achieved for a SNSPD with a detection area of 10 lm 9 10 lm and 62.5 lm multimode fiber coupling. At the same time, a high speed of106 MHz was measured with the proposed system. The realization of a highly compressed optical beam reduced the optical coupling requirement and helped maintain a high speed for the SNSPD. | Labao Zhang Chao Wan Min Gu Ruiying Xu Sen Zhang Lin Kang Jian Chen Peiheng Wu | 2015 | Science Bulletin2015，60，16： | 6 |
| 4 | Current applications and future prospects of nanotechnology in cancer immunotherapy显示文摘Cancer immunotherapy is an artificial stimulation of the immune system to recognize cancer cells and activate specific immune cells to target and attack cancer cells.In clinical trials, immunotherapy has recently shown impressive results in the treatment of multiple cancers.Thus, cancer immunotherapy has gained a lot of attention for its unique advantages and promising future.With extensive research on cancer immunotherapy, its safety and effectiveness has gradually been revealed.However, it is still a huge challenge to expand and drive this therapy while maintaining low toxicity, high specificity, and long-lasting efficacy.As a unique technology, nanotechnology has been applied in many fields, the advantages of which will promote the development of cancer immunotherapies.Researchers have tried to apply nanomaterials to cancer immunotherapy due to their advantageous properties,such as large specific surface areas, effective drug delivery, and controlled surface chemistry, to improve treatment efficacy.Here,we briefly introduce the current applications of nanomaterials in cancer immunotherapy, including adoptive cell therapy(ACT),therapeutic cancer vaccines, and monoclonal antibodies, and throw light on future directions of nanotechnology-based cancer immunotherapy. | Sen Yan Peng Zhao Tingting Yu Ning Gu | 2019 | Cancer Biology & Medicine2019，16，3： | 6 |
| 5 | Novel magnetic silk fibroin scaffolds with delayed degradation for potential long-distance vascular repair显示文摘Although with the good biological properties,silk fibroin(SF)is immensely restrained in long-distance vascular defect repair due to its relatively fast degradation and inferior mechanical properties.It is necessary to construct a multifunctional composite scaffold based on SF.In this study,a novel magnetic SF scaffold(MSFCs)was prepared by an improved infiltration method.Compared with SF scaffold(SFC),MSFCs were found to have better crystallinity,magnetocaloric properties,and mechanical strength,which was ascribed to the rational introduction of iron-based magnetic nanoparticles(MNPs).Moreover,in vivo and in vitro experiments demonstrated that the degradation of MSFCs was significantly extended.The mechanism of delayed degradation was correlated with the dual effect that was the newly formed hydrogen bonds between SFC and MNPs and the complexing to tyrosine(Try)to inhibit hydrolase by internal iron atoms.Besides,theβ-crystallization of protein in MSFCs was increased with the rise of iron concentration,proving the beneficial effect after MNPS doped.Furthermore,although macrophages could phagocytose the released MNPs,it did not affect their function,and even a reasonable level might cause some cytokines to be upregulated.Finally,in vitro and in vivo studies demonstrated that MSFCs showed excellent biocompatibility and the growth promotion effect on CD34-labeled vascular endothelial cells(VECs).In conclusion,we confirm that the doping of MNPs can significantly reduce the degradation of SFC and thus provide an innovative perspective of multifunctional biocomposites for tissue engineering. | Xin Liu Yuxiang Sun Bo Chen Yan Li Peng Zhu Peng Wang Sen Yan Yao Li Fang Yang Ning Gu | 2022 | Bioactive Materials2022，7，1： | 3 |
| 6 | The emerging roles of β-arrestins in fibrotic diseases显示文摘β -Arrestins 和 β -arrestin2 是主要涉及 G-protein-coupled 受体的不敏感性和成为主观的重要适配器蛋白质和信号 transduction 蛋白质。纤维变性被细胞外的矩阵(ECM ) 分子由长期的织物损害引起了的过量的累积描绘。如果高度进步, fibrotic 过程导致机关失灵并且,最后死亡。医不好的肺纤维变性,肾的纤维变性和肝纤维变性在最普通的 fibrotic 疾病之中。最近的研究显示出那 β -arrestins 能激活独立于许多细胞内部的发信号由表明小径的多样的类型联网的 G 蛋白质激活和支架的发信号的串联包括刺猬, Wnt,槽口和转变生长 factor-β小径,以及下游的 kinases 象 MAPK 和 PI3K 那样。这些发信号的小径涉及纤维变性和 fibrotic 疾病的病理学的过程。这 β -arrestin-mediated 规定不仅影响房间生长和 apoptosis,而且 ECM 的免职,煽动性的反应的激活和 fibrotic 疾病的开发。在这评论,我们调查 β 的参与;在各种各样的发信号的小径和热点的 -arrestins 他们纤维变性的规定的不同方面。我们也讨论 β 的重要角色;在由调整 ECM 的发炎和存款的 fibrotic 疾病的过程的 -arrestins。它正在成为更多的明显的那指向 β -arrestins 可以为 fibrotic 疾病的处理提供治疗学的潜力。 | Yuan-jing GU Wu-yi SUN Sen ZHANG Jing-jing WU Wei WEI | 2015 | Acta Pharmacologica Sinica2015，36，11： | 2 |
| 7 | Conversion of Catalytically Inert 2D Bismuth Oxide Nanosheets for Effective Electrochemical Hydrogen Evolution Reaction Catalysis via Oxygen Vacancy Concentration Modulation显示文摘Oxygen vacancies(Vo)in electrocatalysts are closely correlated with the hydrogen evo-lution reaction(HER)activity.The role of vacancy defects and the effect of their concentration,how-ever,yet remains unclear.Herein,Bi2O3,an unfavorable electrocata-lyst for the HER due to a less than ideal hydrogen adsorption Gibbs free energy(ΔGH*),is utilized as a perfect model to explore the func-tion of Vo on HER performance.Through a facile plasma irradia-tion strategy,Bi2O3 nanosheets with different Vo concentrations are fabricated to evaluate the influence of defects on the HER process.Unexpectedly,while the generated oxygen vacancies contribute to the enhanced HER performance,higher Vo concentrations beyond a saturation value result in a significant drop in HER activity.By tunning the Vo concentration in the Bi_(2)O_(3)nanosheets via adjusting the treatment time,the Bi2O3 catalyst with an optimized oxygen vacancy concentration and detectable charge carrier concentration of 1.52×10^(24)cm^(−3)demonstrates enhanced HER performance with an overpotential of 174.2 mV to reach 10 mA cm^(−2),a Tafel slope of 80 mV dec−1,and an exchange current density of 316 mA cm−2 in an alkaline solution,which approaches the top-tier activity among Bi-based HER electrocatalysts.Density-functional theory calculations confirm the preferred adsorption of H*onto Bi2O3 as a function of oxygen chemical potential(ΔμO)and oxygen partial potential(PO2)and reveal that high Vo concentrations result in excessive stability of adsorbed hydrogen and hence the inferior HER activity.This study reveals the oxygen vacancy concentration-HER catalytic activity relationship and provides insights into activating catalytically inert materials into highly efficient electrocatalysts. | Ziyang Wu Ting Liao Sen Wang Janith Adikaram Mudiyanselage Aaron SMicallef Wei Li Anthony PO’Mullane Jianping Yang Wei Luo Kostya Ostrikov Yuantong Gu Ziqi Sun | 2022 | Nano-Micro Letters2022，14，6： | 2 |
| 8 | Withholding consumption~ A social dilemma perspective on consumer boycotts 显示文摘 | Sen S Gu'rhan-Canli Z Morwitz V | 2001 | Journal of Consumer Research2001，28，3： | 1 |
| 9 | Smaller sulfur molecules promise better lithium-sulfur batteries显示文摘 | Xin Sen Gu Lin Zhao Nahong | 2012 | J Am Chem Soc2012，134，18： | 1 |
| 10 | New Algorithm Rules Out Acute-on-chronic Liver Failure Development within 28 Days from Acute Decompensation of Cirrhosis显示文摘Background and Aims:Approximately 10%of patients with acute decompensated(AD)cirrhosis develop acute-on-chronic liver failure(ACLF)within 28 days.Such cases have high mortality and are difficult to predict.Therefore,we aimed to establish and validate an algorithm to identify these patients on hospitalization.Methods:Hospitalized patients with AD who developed ACLF within 28 days were considered pre-ACLF.Organ dysfunction was defined accord-ing to the chronic liver failure-sequential organ failure as-sessment(CLIF-SOFA)criteria,and proven bacterial infec-tion was taken to indicate immune system dysfunction.A retrospective multicenter cohort and prospective one were used to derive and to validate the potential algorithm,re-spectively.A miss rate of<5%was acceptable for the calcu-lating algorithm to rule out pre-ACLF.Results:In the deri-vation cohort(n=673),46 patients developed ACLF within 28 days.Serum total bilirubin,creatinine,international normalized ratio,and present proven bacterial infection at admission were associated with the development of ACLF.AD patients with≥2 organ dysfunctions had a higher risk for pre-ACLF patients[odds ratio=16.58195%confidence interval:(4.271-64.363),p<0.001].In the derivation co-hort,67.5%of patients(454/673)had≤1 organ dysfunction and two patients(0.4%)were pre-ACLF,with a miss rate of 4.3%(missed/total,2/46).In the validation cohort,65.9%of patients(914/1388)had≤1 organ dysfunction,and four(0.3%)of them were pre-ACLF,with a miss rate of 3.4%(missed/total,4/117).Conclusions:AD patients with≤1 organ dysfunction had a significantly lower risk of developing ACLF within 28 days of admission and could be safely ruled out with a pre-ACLF miss rate of<5%. | Xiaoting Tang Hai Li Guohong Deng Xin Zheng Xianbo Wang Yan Huang Yanhang Gao Zhongji Meng Zhiping Qian Feng Liu Xiaobo Lu Yu Shi Beiling Li Wenyi Gu Xiaomei Xiang Yan Xiong Yixin Hou Jun Chen Na Gao Sen Luo Liujuan Ji Jing Li Rongjiong Zheng Haotang Ren Jinjun Chen | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 1 |
| 11 | Synthesis of aluminum oxide-gradient copolymer com- posites by atom transfer radical polymerization 显示文摘 | GU B SEN A | 2002 | Macromolecules2002，35，23： | 1 |
| 12 | Smaller sulfur mole- cules promise better lithium-sulfur batteries显示文摘 | Xin Sen Gu Lin Zhao Nahong | 2012 | Journal of the American Chemical Society2012，134，45： | 1 |
| 13 | The effects of nitridation on the permeability-frequency spectra in nanocrystalline Fe88Zr7B4Cu1 alloys显示文摘 | QIN Wen GAO Wen-li XU Feng PENG Kun YANG Sen ZHANG Jian-rong GU Ben-xi DU You-wei | 2003 | Journal of Physics D:Applied Physics2003，36，2： | 1 |
| 14 | Experimental Study on the Transient Heat Transfer between Hastelloy C-276/Narrow Air Gap/Silicon Steel显示文摘 | ZHU Zhi ZHANG Li wen GU Sen dong | 2013 | Experimental Thermal and Fluid Science2013，45，22： | 1 |
| 15 | Immune response of sea cucumber Apostichopus japonicus coelomocytes to several immunostimulants in vitro 显示文摘 | Gu Minma Hong Mingmai Kang Sen | 2010 | Aquaculture2010，306，： | 1 |
| 16 | Study of STAT3 G-quadruplex folding patterns by CD spectroscopy and molecular modeling显示文摘在 telomere 和 oncogene 倡导者区域从 G 富有的海滨形成的 G 四倍在癌症治疗被认为是新有希望的目标。在信号变换器的下游的 flanking 区域和抄写 3 的使活跃之物(STAT3 )G 四倍的 A 基因被探索。它的合拢的模式被建议是由由 CD 光谱学的变化分析的 3:2:2 和 3:3:1 环异构体。结构被分子的当模特儿的方法构造并且精制。 | Sen Lin Ming Xu Gu Yuan | 2012 | Chinese Chemical Letters2012，23，3： | 1 |
| 17 | 显示文摘 | Gu B Sen A | 2002 | Macromolecules2002，35，23： | 1 |
| 18 | Side channel attack of multiplication in GF(q) –application to secure RSA-CRT显示文摘Dear editor,In the field of side-channel attacks (SCAs), the security of both block ciphers and public key cryptosystems is widely studied after the seminal differential power analysis (DPA)[1]. The straightforward implementations of both types of cryptographic algorithms are vulnerable to SCAs. The former attack methods are based on a comparison of actual leakages and a prior leakage model.The typical one is the correlation power analysis(CPA)[2],which is widely used in both practical attacks and security evalutition.Researchers are dedicated to constructing secure RSA-CRT(Chinese reminder theorem)algorithins to mitigate'both SCAs. | Sen XU Weija WANG Xiangjun LU Zheng GUO Junrong LIU Dawu GU | 2019 | Science China(Information Sciences)2019，62，3： | 1 |
| 19 | The Impacts of Gaming Expansion on Economic Growth: A Theoretical Reconsideration显示文摘 | Li Guoqiang Xinghua Gu Ricardo Chi Sen Siu | 2010 | Journal of Gambling Studies2010，2，： | 1 |
| 20 | The Impacts of Gaming Expansion on Economic Growth: A Theoretical Reconsideration显示文摘 | Li Guoqiang Xinghua Gu Rieardo Chi Sen Siu | 2010 | Journal of Gambling Studies2010，2，： | 1 |
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