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| 1 | Does low volume high-intensity interval training elicit superior benefits to continuous low to moderate-intensity training in cancer survivors?显示文摘AIM To determine the impact ofm low volume high-intensity interval training(LVHIIT) and continuous low to moderate-intensity exercise training(CLMIT) on cardiovascular disease(CVD) risk and health outcomes in cancer survivors.METHODS Sedentary cancer survivors(n=75,aged 51±12year)within 24 months of diagnosis,were randomised into three groups for 12 wk of LVHIIT(n=25),CLMIT(n=25)or control group(n=25).The exercise intervention involved 36 sessions(three sessions per week).The LVHIIT group performed 7 x 30 s intervals(≥85%predicted maximal heart rate)with a 60 s rest between intervals,and the CLMIT group performed continuous aerobic training for 20 min(≤55%predicted maximal heart rate)on a stationary bike.Outcome variables were measured at baseline and at12 weeks and analysed using a 3 x 2(group x time)repeated measures ANCOVA to evaluate main and interaction effects.RESULTS Significant improvements(time)were observed for seven of the 22 variables(ES 0.35-0.97,P≤0.05).There was an interaction effect(P<0.01)after 12 in the LVHIIT group for six-minute walk test(P<0.01;d=0.97;95%CI:0.36,1.56;large),sit to stand test(P<0.01;d=-0.83;95%CI:-1.40,-0.22;large)and waist circumference reduction(P=0.01;d=-0.48;95%CI:-1.10,0.10;medium).An interaction effect(P<0.01)was also observed for quality of life in both the LVHIIT(d=1.11;95CI:0.50,1.72;large)and CLMIT(d=0.57;95%CI:-0.00,1.20;moderate)compared with the control group(d=-0.15;95%CI:-0.95,0.65;trivial).CONCLUSION Low-volume high-intensity training shows promise as an effective exercise prescription within the cancer population,showing greater improvements in cardiorespiratory fitness,lower body strength and waist circumference compared with traditional CLMIT and control groups.Both LVHIIT and CLMIT improved quality of life.A proposed benefit of LVHIIT is the short duration(3 min)of exercise required,which may entice more cancer survivors to participate in exercise,improving health outcomes and lowing the risk of CVD. | Kellie Toohey Kate Pumpa Andrew McKune Julie Cooke Katrina D DuBose Desmond Yip Paul Craft Stuart Semple | 2018 | World Journal of Clinical Oncology2018，9，1： | 3 |
| 2 | Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity显示文摘 | Semple JW Milev Y Cosgrave D | 1996 | Blood1996，87，： | 1 |
| 3 | Comparison of the effects of oviductal cell co-culture and oviductal cell-conditioned medium on the development and metabolic activity of cattle embryos显示文摘 | Grisart B Semple E | 1995 | J Reprod Fertil1995，105，1： | 1 |
| 4 | Differences in serum cy-tokine levels in acute and chronic autoimmune thrombocytopenicpurpura: relationship to platelet phenotype and antiplatelet T一cellreactivity显示文摘 | Semple J W5 Milev 丫 Cosgrave D | 1996 | Blood1996，87，10： | 1 |
| 5 | Recent progress in un-derstanding the pathogenesis of immune thrombocytopenia 显示文摘 | Semple JW Provan D Garvey MB | 2010 | Curr Opin Hematol2010，17，6： | 1 |
| 6 | Anti-D (WinRho SD) treatment of children with chronic autoimmune thrombocytopenic purpura stimulates transient cytokine/chemokine production 显示文摘 | Allen D Rutherford M | 2002 | Am J Hematol2002，69，： | 1 |
| 7 | Dynamics of cryptogamic soil crusts in a derived grassland in southeastern Australia显示文摘 | Eldridge D J Semple W S Koen T B | 2000 | Austral Ecology2000，25，3： | 1 |
| 8 | Seawater tolerance and gene expression in two strains of Atlantic salmon smolts 显示文摘 | SINGER T D CLEMENTS K M SEMPLE J W | 2002 | Canadian Journal of Fisheries and Aquatic Sciences2002，59，1： | 1 |
| 9 | Recent pro- gress in understanding the pathogenesis of immune thrombocytopenia显示文摘 | Semple JW Provan D Garvey MB | 2010 | Current Opinion in Hematolo- gy2010，17，6： | 1 |
| 10 | Clinical review:Vaseulitis on the intensive care unit-part 1:diagnosis显示文摘 | Semple D Keogh J Forni L | 2005 | Crit Care2005，9，1： | 1 |
| 11 | Rapid separation of CD4+ and CD19+ lymphocyte populations from human peripheral blood by a Magnetic Activated Cell Scrter (MACS) 显示文摘 | Semple J W Allen D Chang W | 1993 | Cytometry1993，14，： | 1 |
| 12 | The immunopathogenesis of immune thrombocytopenia: T cells still take center- stage显示文摘 | Semple JW Provan D | 2012 | Current Opinion in Hematology2012，19，5： | 1 |
| 13 | Functional and metabol- ic adaptation in uremic cardiomyopathy 显示文摘 | Smith K Semple D Aksentijevic D | 2010 | Front Biosci ( Elite Ed)2010，2，： | 1 |
| 14 | POCUS: mining genomic sequence annotation to predict disease genes显示文摘 | Turner F S Clutterbuek D R Semple CAM | 2003 | Genome Biology2003，4，11： | 1 |
| 15 | Comparison of the effects of oviductal cell co-culture and oviductal cell-conditioned medium on the development and metabolic activity of cattle embryos显示文摘 | Rieger D Grisart B Semple E | 1995 | Reprod Fertil1995，105，1： | 1 |
| 16 | Clinical review:Vaseulitis on the intensive care unit-part 2:treatment and prognosis显示文摘 | Semple D Keogh J Forni L | 2005 | Crit Care2005，9，2： | 1 |
| 17 | Comparison of the effects of oviductal cell co-culture and oviductal cell conditioned medium on the development and metabolic activity of cattle embryos 显示文摘 | Rieger D Grisart B Semple E | 1995 | Reprod Fertil1995，105，1： | 1 |
| 18 | Transcranial magnetic stimu- lation for auditory hallucinations in schizophrenia 显示文摘 | McIntosh A M Semple D Tasker K | 2004 | Psychiatry Res2004，127，12： | 1 |
| 19 | Recent progress in understanding the pathogenesis of immtme thrombocytopenia 显示文摘 | Semple JW Provan D Garvey MB | 2010 | Curr Opin Hematol2010，17，6： | 1 |
| 20 | Platelet HLA-DR expression is mediated by physical interaction with adherent CD14+ macrophages:Possible role in the pathogenesis of autoimmune thrombocytopenia显示文摘 | Semple JW Mitelman B Allen D | 1995 | Blood1995，86，： | 1 |
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