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| 1 | Effects of estrogen replacement therapy on apoptosis and vascular endothelial growth factor expression in ocular surface epithelial cells:An experimental study显示文摘AIM:To investigate the effects of estrogen replacement therapy (ERT) on apoptosis and vascular endothelial growth factor (VEGF) expression in ocular surface in an experimental rat model.· METHODS:Forty female,Wistar rats were randomized in 4 groups in the study.Subcutaneous ERT (17β-estradiol,10g/kg/day) was administered to the first group without ovariectomy and to the second group with ovariectomy for three months.Third group had only ovariectomy and fourth group had sham operation.All rats were sacrificed in estrous cycles determined by vaginal smear test and their right eyes were enucleated at the end of the third month.Enucleated eyes were analyzed by immunohistochemical method for expressions of caspase-3,bcl-2,VEGF and TUNEL assay.· RESULTS:Caspase-3 expression of conjunctival epithelium was significantly higher in group 3 than group 1 (P =0.005),and group 2 (P =0.007).TUNEL score of conjunctival epithelium was significantly higher in group 3 than group 1 (P =0.006).TUNEL score of corneal epithelium was significantly higher in group 3 than group 2 (P =0.012),and group 4 (P =0.002).There was no significant difference between groups in that bcl-2 and VEGF expressions.· CONCLUSION:We determined increased apoptosis in ocular surface epithelial cells in ovariectomized rats.ERT and endogen estrogen decreased the apoptosis,and did not result in difference in VEGF expression between the groups.Estrogen may be beneficial for the treatment of apoptosis-mediated ocular surface disorders such as dry eye.Further studies are needed on this subject for a better understanding of the role of estrogen and to provide a new insight for treatment and prevention of apoptosis-mediated ocular surface disorders. | Fatih zcura Sema Oru Dndar Emel Dikicioglu etin Nahit Beder Mehmet Dndar | 2012 | International Journal of Ophthalmology(English edition)2012，5，1： | 7 |
| 2 | Gut homeostasis, injury, and healing: New therapeutic targets显示文摘The integrity of the gastrointestinal mucosa plays a crucial role in gut homeostasis,which depends upon the balance between mucosal injury by destructive factors and healing via protective factors.The persistence of noxious agents such as acid,pepsin,nonsteroidal anti-inflammatory drugs,or Helicobacter pylori breaks down the mucosal barrier and injury occurs.Depending upon the size and site of the wound,it is healed by complex and overlapping processes involving membrane resealing,cell spreading,purse-string contraction,restitution,differentiation,angiogenesis,and vasculogenesis,each modulated by extracellular regulators.Unfortunately,the gut does not always heal,leading to such pathology as peptic ulcers or inflammatory bowel disease.Currently available therapeutics such as proton pump inhibitors,histamine-2 receptor antagonists,sucralfate,5-aminosalicylate,antibiotics,corticosteroids,and immunosuppressants all attempt to minimize or reduce injury to the gastrointestinal tract.More recent studies have focused on improving mucosal defense or directly promoting mucosal repair.Many investigations have sought to enhance mucosal defense by stimulating mucus secretion,mucosal blood flow,or tight junction function.Conversely,new attempts to directly promote mucosal repair target proteins that modulate cytoskeleton dynamics such as tubulin,talin,Ehm^(2),filamin-a,gelsolin,and flightless I or that proteins regulate focal adhesions dynamics such as focal adhesion kinase.This article summarizes the pathobiology of gastrointestinal mucosal healing and reviews potential new therapeutic targets. | Sema Oncel Marc D Basson | 2022 | World Journal of Gastroenterology2022，28，17： | 2 |
| 3 | Diffusing capacity limitations of the extent of lung volume reduction surgery in an animal model of emphysema显示文摘 | Chen J C Sema D L Brenner M | 1999 | J Thorac Cardiovasc Surg1999，117，4： | 2 |
| 4 | Effect of implanted Cl^- and deposited oxides on pitting behavior of aluminum显示文摘 | Sema L M Johnson C M Wall F D | 2005 | Journal of the Electrochemical Society2005，152，7： | 1 |
| 5 | Comparison of the clinical efficacy of two different types of post systems which were restored with composite restorations显示文摘AIM To compare the efficacy of resin composite restorations, retained with either polyethylene or zirconia-rich glass fiber posts. METHODS Sixty-two single rooted maxillary and mandibularcentral incisor teeth in forty-four patients (15 males and 29 females; age range 15-32 years) were restored either with an ultrahigh molecular weight polyethylene(UHMWP) fiber post (Bondable Reinforcement Ribbon, DENSE, Ribbond, Seattle, WA, United States) or a zircon-rich glass fiber post (Snowpost, Lot H 040; Carbotech, Ganges, France). Then, direct resin composite restoration (Clearfil AP-X, Kuraray) was performed for both post systems in tooth color suitable. Patients were recalled for routine inspections at 6 mo, 1, 2 and 3 years.RESULTS The restorations were assessed during each recall evaluation according to predetermined clinical and radiographic criteria (periapical lesion; marginal leakage and integrity; color stability; surface stain and loss of retention of the post or the composite buildup material). The follow-up data showed no significant difference in these criteria between polyethylene fibre posts and zirconia-rich glass fibre posts.CONCLUSION The efficacy of resin composite restorations, retained with either polyethylene or zirconia-rich glass fiber posts were similar, suggesting that both types of fiber post can be used successfully to help retain resin composite restorations. | Buket Ayna Emrah Ayna Sema Celenk Emine Goncü Bacaran Berivan Dündar Yιlmaz Ìbrahim Halil Tacir Mehmet Cudi Tuncer | 2018 | World Journal of Clinical Cases2018，6，3： | 1 |
| 6 | Separation of IPA/water mixtures by pervaporation: sorption and pervaporation results显示文摘 | Nilufer D H Sema T | 2004 | Vacuum2004，72，： | 1 |
| 7 | Separation of IPA/water mixtures by pervaporation: sorption and pervaporation results 显示文摘 | Nilufer D H Sema T | 2004 | Vacuum2004，72，： | 1 |
| 8 | Fall Armyworm damaged maize plant identification using digital images显示文摘 | Sema Jr D G | 2003 | Biosystems Engineering2003，85，： | 1 |
| 9 | The Identification of a Dismembered Human Body:a Multidiseiplinary Approach 显示文摘 | Yasar B P Sema K Yesim D A | 2003 | Forensic Science International (S0379-0738)2003，137，23： | 1 |
| 10 | Retrospective evaluation of patient compliance in continuous oxygen therapy显示文摘 | Hande D Tuncalp D Sema U | 2003 | Respiration2003，70，2： | 1 |
| 11 | Pervaporation of MTBE/methanol mixtures through PVA membrane显示文摘 | Nilufer D H Sema T | 2004 | Desalination2004，160，3： | 1 |
| 12 | The identification of a dismembered human body:a multidisciplinary approach显示文摘 | Yasar B Sema P K Yesim D A | 2003 | Forensic Science International2003，137，23： | 1 |
| 13 | A phase i dose escalation and pharmacodynarnie study of SU5416 (Semaxanib) combined with weekly cisplatin and irinotecan in patients with advanced solid tumors 显示文摘 | Martin LK Bekaii-Saab T Sema D | 2013 | Onkologie2013，36，11： | 1 |
| 14 | Retrospective evaluation of patientcompliance in continuous oxygen therapy 显示文摘 | Hande D Tuncalp D Sema U | 2003 | Respiration2003，70，2： | 1 |
| 15 | A phase i dose escalation and pharmacodynamic study of su5416 (semaxanib) combined with weekly cisplatin and irinotecan in patients with advanced solid tumors 显示文摘 | Martin LK Bekaii-Saab T Sema D | 2013 | Onkologie2013，36，11： | 1 |
| 16 | Taylor-Kalman-Fourier Fil-ters for Instantaneous Oscillating Phasor and Harmonic Estimates显示文摘 | J A D Sema Rodriguez Maldonado | 2012 | IEEE Transactions on Instrumentation and measuremerU2012，61，4： | 1 |
| 17 | Efficacy of dicyandiamide as a soil nitrification inhibitor in citrus production 显示文摘 | SEMA M D LEGAZ F PRIMO M E | 1994 | Soil Sci Soc Am1994，，58： | 1 |
| 18 | The influence of nitrogen concentration and ammonium/nitrate ratio on N-uptake, mineral composition and yield of citrus显示文摘 | Sema M D Legaz B Z Primomllo E | 1992 | Plant Soil1992，147，： | 1 |
| 19 | Site-specific Eu(Ⅲ) binding affinities to a Datura innoxia biosorbent显示文摘 | Sema D D Moore J L Rayson G D | 2010 | Journal of Hazardous Materials2010，173，13： | 1 |
| 20 | Covalent immobilization of invertaseon microporous pHEMA-GMA membrane 显示文摘 | Tank D Sema T Yasemin K | 2004 | Food Chemistry2004，85，： | 1 |
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