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| 1 | Hepatocellular carcinoma in Egypt: A single center study over a decade显示文摘AIM: To identify the trend, possible risk factors and any pattern change of hepatocellular carcinoma (HCC) in Egyptover a decade.METHODS: All HCC patients attending Cairo Liver Center between January 1993 and December 2002, were enrolledin the study. Diagnosis of HCC was based on histopath ological examination and/or detection of hepatic focal lesions by two imaging techniques plus α-fetoprotein level above 200 ng/mL. The duration of the study was divided into two periods of 5 years each; period Ⅰ (1993-1997) and period Ⅱ (1998-2002). Trend, demographic features of patients (age, gender, and residence), risk factors (HBsAg,HCV-Ab, schistosomiasis and others) and pattern of the focal lesions were compared between the two periods.Logistic regression model was fitted to calculate the adjusted odds ratios for the potential risk factors. The population attributable risk percentage was calculated to estimate the proportion of HCC attributed to hepatitis B and C viral infections.RESULTS: Over a decade, 1 328 HCC patients out of 22 450 chronic liver disease (CLD) patients were diagnosed with an overall proportion of 5.9%. The annual proportion of HCC showed a significant rising trend from 4.0% in 1993 to 7.2% in 2002 (P = 0.000). A significant increase in male proportion from 82.5% to 87.6% (P = 0.009); M/F from 5:1 to 7:1 and a slight increase of the predominant age group (40-59 years) from 62.6% to 66.8% (P = 0.387)in periods Ⅰ and Ⅱ respectively, reflecting a shift to younger age group. In the bivariate analysis, HCC was significantly higher in rural residents, patients with history of schistosomiasis and/or blood transfusion. Yet, after adjustment, these variables did not have a significant risk for development of HCC. There was a significant decline of HBsAg from 38.6% to 20.5% (P = 0.000), and a slight increase of HCV-Ab from 85.6% to 87.9% in periods Ⅰ and Ⅱ respectively. HBV conferred a higher risk to develop HCC more than HCV in period Ⅰ (OR 1.9 vs 1.6) and period Ⅱ (OR 2.7 vs 2.0), but the relative contribution of HBV for development of HCC declined in period Ⅱ compared to period Ⅰ (PAR% 4.2%, 21.32%). At presentation,diagnostic α-fetoprotein level (≥200 ng/mL) was demonstrated in 15.6% vs28.9% and small HCC (≤3 cm)represented 14.9% vs 22.7% (P = 0.0002) in periods Ⅰ and Ⅱ respectively.CONCLUSION: Over a decade, there was nearly a twofold increase of the proportion of HCC among CLD patients in Egypt with a significant decline of HBV and slight increase of HCV as risk factors. α-Fetoprotein played a limited role in diagnosis of HCC, compared to imaging techniques.Increased detection of small lesions at presentation reflects increased awareness of the condition. | Adbel-Rahman El-Zayadi Hanaa M Badran Eman MF Barakat Mohy El-Deen Attia Sherine Shawky Mostafa K Mohamed Osaima Selim Ahmed Saeid | 2005 | World Journal of Gastroenterology2005，11，33： | 5 |
| 2 | Is there a role for endothelin-1 in the hemodynamic changes during hemodialysis显示文摘 | EI-Shafey EM EI-Nagar GF Selim MF | | 0，，： | 1 |
| 3 | Is there a role for endothelin-1 in the hemodynamic changes during hemodialysis? 显示文摘 | el-Shafey EM el-Nagar GF Selim MF | 2008 | Clin Exp Nephrol2008，12，5： | 1 |
| 4 | Is serum cystatin C an ac-curate endogenous marker of glomerular filteration rate for detection of early renal impairment in patients with type 2 diabetes mellitus显示文摘 | El-Shafey EM El-Nagar GF Selim MF | 2009 | Ren Fail2009，31，5： | 1 |
| 5 | Is serum cystatin C an accurate endogenous marker of glnmerular filtration rate for detection of early renal impairment in patients with type 2 diabetes mellitus显示文摘 | E1-Shafey EM E1-Nagar GF Selim MF | 2009 | Ren Fail2009，31，5： | 1 |
| 6 | Is serum cystatin C an accurate endogenous marker of glomerular filteration rate for detection of early renal impairment in patients with type 2 diabetes mellitus显示文摘 | El-Shafey EM El-Nagar GF Selim MF | 2010 | Nephron Clin Pract2010，114，： | 1 |
| 7 | Is serum cystatin C an accurate endogenous marker of glomerular filtration rate for detection of early renal impairment in patients with type 2 diabetes mellitus显示文摘 | El-Shafey EM El-Nagar GF Selim MF | | 0，，： | 1 |
| 8 | Comparative evaluation of epidural bupivacaine - dexmedetomidine and bupivacaine -fentanyl on Doppler velocimetry of uterine and umbilical arteries during labor 显示文摘 | Selim MF Elnabtity AM Hasan AM | 2012 | J Prenat Med2012，6，： | 1 |
| 9 | Comparative evaluation of epidural bupivacaine-dexmedetomidine and bupivacaine-fentanyl on Doppler velocimetry of uterine and umbilical arteries during labor显示文摘 | Selim MF Elnabtity AM Hasan AM | 2012 | J Prenat Med2012，6，3： | 1 |
| 10 | Is serum cystatin C an accurate endogenous marker of glomerular filteration rate for detection of early renal impairment in patients with type 2 diabetes mellitus? 显示文摘 | E1-Shatey EM E1-Nagar GF Selim MF | 2009 | Ren Fail2009，31，5： | 1 |
| 11 | Comparative evaluation of epidural bupivacaine - dexmedetomidine and bupivacaine - fentanyl on Doppler velocimetry of uterine and umbilical arteries during labor显示文摘 | Selim MF Elnabtity AM Hasan AM | 2012 | J Prenat Med2012，6，3： | 1 |
| 12 | Is serum cystatin C an accurate en- dogenous marker of g|omerular filteration rate for detection of early renal impairment in patients with type 2 diabetes mellitus? 显示文摘 | E1-Shafey EM El-Nagar GF Selim MF | 2009 | Ren Fail2009，31，5： | 1 |
| 13 | Is serum cystatin C an accurate endogenous marker of glomerular filteration rate for detection of early renal impairment in patients with type 2 diabetes mellitus?显示文摘 | El-Shafey EM El-Nagar GF Selim MF | 2009 | Ren Fail2009，31，5： | 1 |
| 14 | Is there a role for endothelin-1 in the hemodynamic changes during hemodialysis?显示文摘 | El-Shafey EM El-Nagar GF Selim MF | 2008 | Clin Exp Nephrol2008，12，： | 1 |
| 15 | Comparative evaluation of epidural bupivacaine - dexmedetomidine and bupivacaine -fentanyl on Doppler velocimetry of uterine and umbilical arteries during labor显示文摘 | Selim MF Elnabtity AM Hasan AM | 2012 | J Prenat Med2012，6，3： | 1 |
| 16 | Endothelial function in women using levonorgestrel-releasing intrauterine system (LNG-IUS) 显示文摘 | Selim MF Hussein AF | 2013 | Contra- ception2013，87，4： | 1 |
| 17 | Comparative evaluation of epi- dural bupivacaine-dexmedetomidine and bupivacaine-fentanyl on Doppler velocimetry of uterine and umbilical arteries during labor显示文摘 | Selim MF Elnabtity AM Hasan AM | 2012 | J Prenat Med2012，6，3： | 1 |
| 18 | Is serum cystatin C an accurate endogenous marker of glomerular filteration rate for detection of early renal impairment in patients with type 2 diabetes mellitus?显示文摘 | El-Shafey EM El-Nagar GF Selim MF | 2009 | Ren Fail2009，31，： | 1 |
| 19 | Is serumcystatin C an accurate endogenous marker of glomerularfiltration rate for detection of early renal impairment in pa-tients with type 2 diabetes mellitus 显示文摘 | EL-Shafey EM’EL-Nagar GF Selim MF | 2009 | Ren Fail2009，31，5： | 1 |
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