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| 1 | Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer显示文摘AIM: To investigate the expression levels of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), vascular endothelial growth factor receptor-3 (VEGFR-3) and CD44 genes and the relationship between their lev- els and clinicopathological parameters in gastric cancer.METHODS: Tissue samples were obtained from 33 patients (8 females) with gastric cancer. mRNA levels of LYVE-1, VEGFR-3 and CD44 in normal and tumor tissues were quantitatively measured using real time polymerase chain reaction. The results were correlated with lymph node metastasis, histological type and differentiation of the tumor, T-stage, and presence of vascular, perineural and lymphatic invasions. The distribution of molecules in the tissue was evaluated using immunohistochemistry. RESULTS: LYVE-1, CD44 and VEGFR-3 gene expression levels were significantly higher in gastric cancer than in normal tissue. While there was no correlation between gene expressions and clinicopathologic fea- tures such as histologic type, differentiation and stage, gene expression levels were found to be increased in conjunction with positive lymph node/total lymph node ratio and the presence of perineural invasion. A significant correlation was also found between LYVE-1 and CD44 over-expressions and perineural invasion and lymph node positivity in gastric cancers. When the dis- tribution of LYVE-1 antibody-stained lymphatic vessels in tissue was evaluated, lymphatic vessels were located intra-tumorally in 13% and peri-tumorally in 27% of the patients. Moreover, lymph node metastases were also positive in all patients with LYVE-1-staining. CONCLUSION: LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis. LYVE-1 is a perfectly reliable lymphatic vessel marker and useful for immunohistochemistry. | Fusun Ozmen M Mahir Ozmen Evren Ozdemir Munevver Moran Selda Sekin Dicle Guc Ergun Karaagaoglu Emin Kansu | 2011 | World Journal of Gastroenterology2011，17，27： | 27 |
| 2 | Membrane bioreactor (MBR) treatment of segregated household wastewater for reuse 显示文摘 | Elif A Selda M Ahmet B | 2007 | Clean2007，35，5： | 1 |
| 3 | The evaluation of some flexural properties of a denture base resin reint'orced with various aesthetic fibers显示文摘 | ORHAN M D GIRAY B SELDA K | 2008 | J Mater Sci: Mater Med2008，19，： | 1 |
| 4 | Digital topics on cultural heritage investigated:how can data-driven and data-guided methods support to identify current topics and trends in digital heritage?显示文摘In research and policies,the identifcation of trends as well as emerging topics and topics in decline is an important source of information for both academic and innovation management.Since at present policy analysis mostly employs qualitative research methods,the following article presents and assesses diferent approaches–trend analysis based on questionnaires,quantitative bibliometric surveys,the use of computer-linguistic approaches and machine learning and qualitative investigations.Against this backdrop,this article examines digital applications in cultural heritage and,in particular,built heritage via various investigative frameworks to identify topics of relevance and trendlines,mainly for European Union(EU)-based research and policies.Furthermore,this article exemplifes and assesses the specifc opportunities and limitations of the diferent methodical approaches against the backdrop of data-driven vs.data-guided analytical frameworks.As its major fndings,our study shows that both research and policies related to digital applications for cultural heritage are mainly driven by the availability of new technologies.Since policies focus on meta-topics such as digitisation,openness or automation,the research descriptors are more granular.In general,data-driven approaches are promising for identifying topics and trendlines and even predicting the development of near future trends.Conversely,qualitative approaches are able to answer“why”questions with regard to whether topics are emerging due to disruptive innovations or due to new terminologies or whether topics are becoming obsolete because they are common knowledge,as is the case for the term“internet”. | Sander Münster Ronja Utescher Selda Ulutas Aydogan | 2021 | Built Heritage2021，5，3： | 0 |
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