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| 1 | Advances in cellulose ester performance and application显示文摘 | Kevin J Edgar Charles M Buchanan John S Debenham Paul A Rundquist Brian D Seiler Michael C Shelton Debra Tindall | 2001 | Progress in Polymer Science2001，，9： | 2 |
| 2 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 3 | Micromachining a miniaturized capillary electrophoresis-based chemical analysis system on a chip显示文摘 | Harrison D J Fluri K Seiler K | 1993 | Science1993，261，5123： | 1 |
| 4 | Tumour necrosis factor-alpha and interleukin-6 release during primary percutaneous coronary intervention for acute myocardial infarction is related to coronary collateral flow显示文摘 | Rakhit R D Seiler C Wustmann K | 2005 | Coron Artery Dis2005，16，3： | 1 |
| 5 | Effect of core stability training on throwing velocity in female handball players显示文摘 | A H ROLAND V D T Seiler S | 2011 | J Strength Cond Res2011，25，3： | 1 |
| 6 | Evaluation and bioinduction of energy components of Jatropha curcas显示文摘 | AUGUSTUS G D P S JAYABALAN M SEILER G J | 2002 | Biomass and Bioenergy2002，23，： | 1 |
| 7 | Physiological and morphological responses of three half- sib families of loblolly pine to water-stress conditioning显示文摘 | Seiler J R Johnson J D | 1988 | Forest Science1988，34，2： | 1 |
| 8 | Larrabee: A manycore x86 architecture for visual computing显示文摘 | Seiler L Carmean D Sprangle E | 2008 | ACM Transactions on Graphics2008，27，3： | 1 |
| 9 | Holmium:YAG thermokeratoplasty for correction of astigmatism 显示文摘 | Thompson VM Seiler T Durrie D | 1993 | Refract Corneal Surg1993，9，： | 1 |
| 10 | Evaluation and bioinduction of energy components of Jatropha curcas 显示文摘 | Augustusa G D P S Jayabalan M Seiler G J | 2002 | Biomass and Bioenery2002，23，： | 1 |
| 11 | Four-glass or two glass test for chronic prostatitis 显示文摘 | Seiler D Zbinden R Hauri D | 2003 | Urologe A2003，42，2： | 1 |
| 12 | Carbon el- flux rates of fine roots of three tree species decline shortly after excision 显示文摘 | RAKONCZAY Z SEILER J R KELTING D L | 1997 | Environmental and experimental botany1997，38，3： | 1 |
| 13 | Micromachining a miniaturized capillary electrophoresis-based chemical analysis system on a chip显示文摘 | Fluri K Seiler K | 1993 | Science1993，261，： | 1 |
| 14 | Carbon efflux rates of fine root s of three tree species decline shortly after excision显示文摘 | Rakonczay Z Seiler J R Kelting D L | 1997 | Envi ronmental and Ex perimental Botany1997，8，： | 1 |
| 15 | CCND1/CyclinD1 status in metastasizing bladder cancer: a prognosticator and predictor of chemotherapeutic response显示文摘 | Seiler R Thalmann GN Rotzer D | 2014 | Mod Pathol2014，27，1： | 1 |
| 16 | CCND1/Cyclin D1 status in metastasizing bladder cancer: a prognosticator and predictor of chemotherapeutic response显示文摘 | Seiler R Thalmann G N Rotzer D | 2014 | Mod Pathol2014，27，1： | 1 |
| 17 | A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site : e,Jidence for C - F… = O interactions显示文摘 | Olsen J A Banner D W Seiler P | 2003 | Angew Chem Int Ed2003，115，： | 1 |
| 18 | Vision change after sheet transplant of fetal retina with retinal pigment epithelium to a patient with retinitis pigmentosa显示文摘 | Radtke ND Aramant RB Seiler MJ Petry HM Pidwell D | 2004 | Arch Ophthalmol2004，122，8： | 1 |
| 19 | Four-glass or two-glass test for chronic prostatitis显示文摘 | Seiler D Zbinden R Hauri D | 2003 | Urology2003，42，2： | 1 |
| 20 | Micromachi-ning a miniaturized capillary electrophoresis based chemical analysis system on a chip 显示文摘 | FLURI K SEILER K | 1993 | Science1993，261，： | 1 |
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