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| 1 | 高盐饮食通过促进蛋白tau磷酸化损伤大脑认知功能显示文摘来自美国威尔康乃尔医学院的研究人员在一项新的针对小鼠的研究发现,高盐饮食可能会导致化合物一氧化氮的缺乏,从而对认知功能产生负面影响;当一氧化氮水平过低时,大脑中蛋白tau发生磷酸化,从而导致痴呆症。该论文最近在线发表在Nature上。在这项新的研究中,研究人员试图了解食盐摄入与较差认知功能间的关系,发现血管中一氧化氮产生的减少可通过抑制一系列导致蛋白tau病变的酶的活性而影响神经元中tau蛋白的稳定性,而蛋白tau为神经元的支架(细胞骨架)提供结构,一旦蛋白tau脱离细胞骨架则会在大脑中积聚并引起认知问题。因此这些研究人员得出结论:降低食盐摄入量并维持大脑中的健康血管可能“避免”痴呆症。 | FARACO G HOCHRAINER K SEGARRA S G 本刊编辑部 | 2019 | 实用心脑肺血管病杂志2019，27，10： | 8 |
| 2 | Baseline of butyltin pollution in coastal sediments within the Basque Country (northern Spain), in 2007-2008显示文摘 | Rodriguez J G~ Solaun O Larreta J Segarra M J B Franco J Alonso J I G Sariego C Valencia V Borja A | 2010 | Marine Pollution Bulletin2010，60，1： | 1 |
| 3 | Physiological effects of the induction of resistance by compost or Tr/choderma aspereum strain I34 against Botryt/ dnerea in tmato显示文摘 | Femmdez E Segarra G Trillas M I | 2014 | Biological Control2014，78，6： | 1 |
| 4 | Use of serial analysis of gene expression (SAGE) technology reveals new granulocyte markers显示文摘 | Bertrand G Coste J Segarra C | 2004 | J Immunol Methods2004，292，12： | 1 |
| 5 | Proteome,salicylic acid,and ias- monic acid changes in cucumber plants inoculated with Trichoderma asperel- lure strain T34显示文摘 | Segarra G Casanova E Bellido D | 2007 | Proteomics2007，7，21： | 1 |
| 6 | Vascular aging in women : is estrogen the fountain of youth显示文摘 | Novella S Dantas AP Segarra G | 2012 | Front Physiol2012，3，： | 1 |
| 7 | Vascular aging in women: is estrogen the fountain of youth? 显示文摘 | Novella S Dantas AP Segarra G | 2012 | Front Physiol2012，3，1： | 1 |
| 8 | Effects of some guani- dine compounds on human cerebral arteries显示文摘 | Segarra G Medina P Ballester RM | 1999 | Storke1999，30，10： | 1 |
| 9 | Relaxation and cGMP formation in response to sildenafil and sodium nitroprusside in saphenous veins from normotensive and hypertensive patients 显示文摘 | Medina P Segarra G Martinez-Leon JB | 2002 | Am J Hypertens2002，15，9： | 1 |
| 10 | The advanced information technology innovation road map 显示文摘 | Segarra G | 1999 | Computers in Industry1999，40，： | 1 |
| 11 | Inhibition of neuroef-fector transmission in human vas deferens by sildenafil 显示文摘 | Medina P Segarra G Torondel B | 2000 | Br J Pharmacol2000，131，5： | 1 |
| 12 | Effects of some guanidino compounds on human cerebral arteries显示文摘 | Segarra G Medina P Ballester RM et a1 | 1999 | Stroke1999，30，10： | 1 |
| 13 | Vascular aging in women : is estrogen the foun- tain of youth? 显示文摘 | Novella S Dantas AP Segarra G | 2012 | Front Physiol2012，3，： | 1 |
| 14 | Aging-related endothelial dysfunction in the aorta from female senescence accelerated mice is associated with decreased nitric oxide synthase expression显示文摘 | Novella S Dantas AP Segarra G el al | 2013 | Experimental Gerontology2013，48，11： | 1 |
| 15 | Enhanced Use of Renewable Resources:Transesterification of Glycerol Catalyzed by Hydrotalcite-Like Compounds显示文摘 | Alvarez M G Segarra A M ContrerasS | 2010 | Chem Eng J2010，161，3： | 1 |
| 16 | Proteome, salicylic acid, andjasmonic acid changes in cucumber plants inoculated with Trichoder-ma asperellum strain T34显示文摘 | Segarra G Casanova E Bellido D | 2007 | Proteomics2007，7，： | 1 |
| 17 | Endothelium-dependent responses in human isolated thyroid arteries from donors显示文摘 | Vila JM Segarra G | 2004 | J Endocrinol2004，181，3： | 1 |
| 18 | Dietary fatty acid composition affects aminopeptidase activitie~s in the testes of mice显示文摘 | Arechaga G Prieto I Segarra AB | 2002 | Int J Androl2002，25，2： | 1 |
| 19 | Effects of some guanidino compounds on human cerebral arteries显示文摘 | Segarra G Medina P Ballester RM | 1999 | Stroke1999，30，10： | 1 |
| 20 | Proteome, salicylic acid, and jasmonic acid changes in cucumber plants inoculated with Trichoderma asperellum strain T34显示文摘 | SEGARRA G CASANOVA E BELLIDO D | 2007 | Proteomics2007，7，21： | 1 |
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