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| 1 | Rare primary lymphoepithelioma-like carcinoma of the renal pelvis显示文摘Lymphoepithelioma-like carcinoma(LELC)is a rare,malignant epithelial tumour which can arise within the upper urinary tract.This letter adds to a previous systematic review and cumulative analysis of 28 published upper urinary tract-LELC cases which provided insight into this disease;however,the current evidence does not provide clinicians with clear guidelines due to its rarity.Therefore,the aim was to report a new case of renal pelvis LELC presented in our hospital.In this instance,we were able to report treatment experience and longterm follow-up results.This patient presented with hypertension and haemturia which initiated further investigation.While ultrasound identified an hypechoic mass,no malignant cells were detected using cytological testing.Abdominal magnetic resonance imaging identified a slightly enhanced mass in the left renal pelvis with no evidence of lymph node metastasis.Ureteroscopic tumor biopsy suggested the existence of urothelial carcinoma,hence,laparoscopic radical left nephroureterectomy with bladder cuff excision was performed.Through patientpractitioner consultations,we decided to adopt a'watch and wait'approach after radical nephroureterectomy rather than administering chemotherapy.Although,we would encourage clinicians to record and publish cases to garner insight into this type of malignant disease. | Shi-Cong Lai Samuel Seery Tong-Xiang Diao Jian-Ye Wang Ming Liu | 2020 | World Journal of Clinical Cases2020，8，9： | 5 |
| 2 | Efficacy and safety of lenvatinib for patients with advanced hepatocellular carcinoma: A retrospective, real-world study conducted in China显示文摘BACKGROUND Lenvatinib has become an indispensable part of treatment regimens for patients with advanced hepatocellular carcinoma(aHCC).Several recent real-world studies appear to have confirmed this;however,there are etiological differences.This necessitates further real-world studies of lenvatinib across diverse populations,such as in China.AIM To investigate the efficacy and safety of lenvatinib in a Chinese HCC patient population under real-world conditions.METHODS This is a retrospective and multiregional study involving patients with aHCC receiving lenvatinib monotherapy.Efficacy was assessed using the Response Evaluation Criteria in Solid Tumors version 1.1.Baseline characteristics and adverse events(AEs)were recorded throughout the entire study.RESULTS In total,54 HCC patients treated with lenvatinib monotherapy were included for final analysis.The objective response rate was 22%(n=12)with a progressionfree survival(PFS)of 168 d;however,AEs occurred in 92.8%of patients.Multivariate analysis showed that the Barcelona Clinic Liver Cancer stage[hazard ratio(HR)0.465;95%CI:0.23-0.93;P=0.031],portal vein tumor thrombus(HR 0.38;95%CI:0.15-0.94;P=0.037)and Child-Pugh classifications(HR 0.468;95%CI:and specificity(83.3%)of decreasing serum biomarkers including alphafetoprotein were calculated in order to predict tumor size reduction.Gene sequencing also provided insights into potential gene mutation signatures related to the effect of lenvatinib.CONCLUSION Our findings confirm previous evidence from the phase III REFLECT study.The majority of patients in this Chinese sample were suffering from concomitant hepatitis B virus-related HCC.However,further analysis suggested that baseline characteristics,changes in serum biomarkers and gene sequencing may hold the key for predicting lenvatinib responses.Further large-scale prospective studies that incorporate more basic medical science measures should be conducted. | Dong-Xu Wang Xu Yang Jian-Zhen Lin Yi Bai Jun-Yu Long Xiao-Bo Yang Samuel Seery Hai-Tao Zhao | 2020 | World Journal of Gastroenterology2020，26，30： | 4 |
| 3 | Oncological impact of different distal ureter managements during radical nephroureterectomy for primary upper urinary tract urothelial carcinoma显示文摘BACKGROUND The current standard surgical treatment for non-metastatic upper urinary tract urothelial carcinoma(UTUC)is radical nephroureterectomy(RNU)with bladder cuff excision(BCE).Typically,BCE techniques are classified in one of the following three categories:An open technique described as intrasvesical incision of the bladder cuff,a transurethral incision of the bladder cuff(TUBC),and an extravesical incision of the bladder cuff(EVBC)method.Even though each of these management techniques are widely used,there is no consensus about which surgical intervention is superior,with the best oncologic outcomes.AIM To investigate the oncological outcomes of three BCE methods during RNU for primary UTUC patients.METHODS We retrospectively analyzed the data of 248 primary UTUC patients,who underwent RNU with BCE between January 2004 to December 2018.Patients were analyzed according to each BCE method.Data extracted included patient demographics,perioperative parameters,and oncological outcomes.Statistical analyses were performed using chi-square and log-rank tests.The Cox proportional hazards regression model was utilized to identify independent predictors.P<0.05 was considered statistically significant.RESULTS Of the 248 participants,39.9%(n=99)underwent intrasvesical incision of the bladder cuff,38.7%(n=96)EVBC,and 21.4%(n=53)TUBC.At a median followup of 44.2 mo,bladder recurrence developed in 17.2%,12.5%,and 13.2%of the cases,respectively.Cancer-specific deaths occurred in 11.1%,5.2%,and 7.5%of patients,respectively.Kaplan-Meier survival curves with a log-rank test highlighted no significant differences in intravesical recurrence-free survival,cancer-specific survival,and overall survival among these approaches with P values of 0.987,0.825,and 0.497,respectively.Multivariate analysis showed that the lower ureter location appears to have inferior intravesical recurrence-free survival(P=0.042).However,cancer-specific survival and overall survival were independently influenced by tumor stage(hazard ratio[HR]=8.439;95%condence interval:2.424-29.377;P=0.001)and lymph node status(HR=14.343;95%CI:5.176-39.745;P<0.001).CONCLUSION All three techniques had comparable outcomes;although,EVBC and TUBC are minimally invasive.While based upon rather limited data,these findings will support urologists in blending experience with evidence to inform patient choices.However,larger,rigorously designed,multicenter studies with long term outcomes are still required. | Shi-Cong Lai Peng-Jie Wu Jian-Yong Liu Samuel Seery Sheng-Jie Liu Xing-Bo Long Ming Liu Jian-Ye Wang | 2020 | World Journal of Clinical Cases2020，8，21： | 2 |
| 4 | Speckle-tracking echocardiography for detecting myocardial dysfunction in sepsis and septic shock patients:A single emergency department study显示文摘BACKGROUND:Septic cardiomyopathy(SCM)occurs in the early stage of sepsis and septic shock,which has implications for treatment strategies and prognosis.Additionally,myocardial involvement in the early stages of sepsis is difficult to identify.Here,we assess subclinical myocardial function using laboratory tests and speckle-tracking echocardiography(STE).METHODS:Emergency department patients diagnosed with sepsis or septic shock were included for analysis.Those with other causes of acute or pre-existing cardiac dysfunction were excluded.Transthoracic echocardiography(TTE),including conventional echocardiography and STE,were performed for all patients three hours after initial resuscitation.Samples for laboratory tests were taken around the time of TTE.RESULTS:Left ventricular functions of 60 patients were analyzed,including 21 septic shock patients and 39 sepsis patients.There was no significant difference in global longitudinal strain(GLS),global circumferential strain(GCS),or global radical strain(GRS)between patients with sepsis and septic shock(all with P>0.05).However,GLS and GCS were significantly less negative in patients with abnormal troponin levels or in patients with abnormal left ventricular ejection fraction(LVEF)values(all with P<0.05).There were also moderate correlations between GLS and levels of cTnI(r=0.40,P=0.002)or N-terminal pro-B-type natriuretic peptide(NT-proBNP)(r=0.44,P=0.001)in sepsis and septic shock patients.CONCLUSION:Myocardial dysfunction,e.g.,lower LVEF or less negative GLS in patients with sepsis or septic shock,is more affected by myocardial injury.GLS could be incorporated into mainstream clinical practice as a supplementary LVEF parameter,especially for those with elevated troponin levels. | Xuan Fu Xue Lin Samuel Seery Li-na Zhao Hua-dong Zhu Jun Xu Xue-zhong Yu | 2022 | World Journal of Emergency Medicine2022，13，3： | 2 |
| 5 | Stem cells of the esophageal epithelium 显示文摘 | Seery JP | 2002 | Cell Sci2002，115，： | 1 |
| 6 | Mortality risk after preoperative versus postoperative chemotherapy and radiotherapy in lymph node-positive rectal cancer显示文摘 | Seery T E Ziogas A Lin B S | 2013 | Journal of Gastrointestinal Surgery2013，17，2： | 1 |
| 7 | Effect of N-doping on the photocatalytic activity of sol-gel TiOz显示文摘 | Nolana N T Synnott D W Seery M K | 2012 | Journal of Hazardous Ma?terials2012，，： | 1 |
| 8 | A Highly Efficient Ag- ZnO Photocatalyst: Synthesis, Properties, and Mechanism显示文摘 | Georgekutty R Seery M K Pillai S C | 2008 | The Joural of Physical Chemistry C2008，112，13： | 1 |
| 9 | The James Webb Space Telescope (JWST) : Hubble's scientific and technological successor显示文摘 | SEERY B D | 2003 | SPIE2003，4850，： | 1 |
| 10 | Tat-mediated delivery of heterologous proteins into cells 显示文摘 | Fawell S Seery J Daikh Y | 1994 | Proc Natl Aead Sci USA1994，91，： | 1 |
| 11 | 查看详情显示文摘 | Georgekutty R Seery M K Pillai S C | | 0，，35： | 1 |
| 12 | Silver doped titanium dioxide nanomaterials for enhanced visible light photocatalysis 显示文摘 | SEERY M K GEORGE R FLORIS P | 2007 | Journal of Photochemistry and Photobiology A: Chemistry2007，189，2： | 1 |
| 13 | Temozolomide in malignant gliomas: current use and future targets显示文摘 | J. Lee Villano Tara E. Seery Linda R. Bressler | 2009 | Cancer Chemotherapy and Pharmacology2009，，4： | 1 |
| 14 | Tat-mediated delivery of heterologous protein into cells显示文摘 | Fawell S Seery J Daikh Y | 1994 | Proc Natl Acad Sci USA1994，91，2： | 1 |
| 15 | Static and dy- namic light scttering charaterization of hydrophobically associating tluorocarbon-containing polymers 显示文摘 | Seery T A P Yassini M Hogen-Esch T E | 1992 | Macro- molecules1992，25，18： | 1 |
| 16 | Role of surgical resection among chemotherapy-treated patients with colorectal cancer stage IV disease: A survival analysis 显示文摘 | Lin BS Ziogas A seery TE | 2011 | J Clin Oncol2011，，： | 1 |
| 17 | Treatment of black -tailed prairie dog burrows with dehamethrin to control fleas (Insecta: Siphonaptera) and plague显示文摘 | DB Seery DE Biggins JA Montenieri | 2003 | J Med Enthmol2003，40，5： | 1 |
| 18 | Packet transport trends: IP/MPLS Success challenged as deployment footprint expands显示文摘 | Seery M | 2008 | IEEE Communications Magazine2008，46，7： | 1 |
| 19 | Tat mediated delivery of heterologous proteins into cells显示文摘 | Fawell S Seery J Daikh Y | 1994 | Proc Natl Acad Sci USA1994，91，： | 1 |
| 20 | BRCA1 expression levels predict distant metastasis of sporadic breast cancers显示文摘 | Seery LT Knowlden JM Gee JM | 1999 | Int J Cancer1999，84，5： | 1 |
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