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| 1 | Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism显示文摘Antibacterial activity of zinc oxide nanoparticles(Zn O-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. Many microorganisms exist in the range from hundreds of nanometers to tens of micrometers. Zn O-NPs exhibit attractive antibacterial properties due to increased specific surface area as the reduced particle size leading to enhanced particle surface reactivity. Zn O is a bio-safe material that possesses photo-oxidizing and photocatalysis impacts on chemical and biological species. This review covered Zn O-NPs antibacterial activity including testing methods, impact of UV illumination, Zn O particle properties(size, concentration, morphology, and defects), particle surface modification, and minimum inhibitory concentration. Particular emphasize was given to bactericidal and bacteriostatic mechanisms with focus on generation of reactive oxygen species(ROS) including hydrogen peroxide(H2O2), OH-(hydroxyl radicals), and O2-2(peroxide). ROS has been a major factor for several mechanisms including cell wall damage due to Zn O-localized interaction, enhanced membrane permeability, internalization of NPs due to loss of proton motive force and uptake of toxic dissolved zinc ions.These have led to mitochondria weakness, intracellular outflow, and release in gene expression of oxidative stress which caused eventual cell growth inhibition and cell death. In some cases, enhanced antibacterial activity can be attributed to surface defects on Zn O abrasive surface texture. One functional application of the Zn O antibacterial bioactivity was discussed in food packaging industry where Zn O-NPs are used as an antibacterial agent toward foodborne diseases. Proper incorporation of Zn O-NPs into packaging materials can cause interaction with foodborne pathogens, thereby releasing NPs onto food surface where they come in contact with bad bacteria and cause the bacterial death and/or inhibition. | Amna Sirelkhatim Shahrom Mahmud Azman Seeni Noor Haida Mohamad Kaus Ling Chuo Ann Siti Khadijah Mohd Bakhori Habsah Hasan Dasmawati Mohamad | 2015 | Nano-Micro Letters2015，7，3： | 76 |
| 2 | In vitro multiplication and ecorehabilitation of the endangerd Blue Vanda显示文摘 | Seeni S Latha P.G | | 0，，： | 1 |
| 3 | Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model显示文摘 | Seeni A Takahashi S Takeshita K | 2008 | Cancer Prevention2008，9，1： | 1 |
| 4 | Isozymes of glucose262phosphate dehydrogenase and NAD+2malate dehydrogenase in shoot-forming foliar discs of tobacco显示文摘 | Seeni S A Gnanam A | 1981 | Plant Cell Physiol1981，22，： | 1 |
| 5 | FoliarregenerationoftheendangeredRedvanda,RenantheraimschootianaRolfe显示文摘 | SeeniS LathaPG | 1992 | PlantCellTissueandOrganCulture1992，29，： | 1 |
| 6 | Foliar regeneration of the endangered Red vanda,Renanthera imschootiana Rolfe显示文摘 | SEENI S LATHA P G | 1976 | Am Orchid Soc Bult1976，22，6： | 1 |
| 7 | lsozymes of glucose-6-phosphate dehydrogenate in shoot-forming foliar discs of tobacco显示文摘 | Seeni S A Gnanam A | 1981 | Plant Cell Physiol1981，22，： | 1 |
| 8 | In vitro multiplication and field establish- ment of Adhatoda beddomei CB Clarke, a rare medicinal plant 显示文摘 | Sudha CG Seeni S | 1994 | Plant Cell Rep1994，13，34： | 1 |
| 9 | Foliar regeneration of the endangered Red vanda, Renanthera imsehootiana Rolfe显示文摘 | Seeni S Latha P G | 1976 | Am Orchid Soc Bolt1976，45，： | 1 |
| 10 | Ammonium nitrate in the culture medium influences regeneration potential of cryopreserved shoot tips of Holostemma annulare 显示文摘 | Decruse W S Seeni S | 2002 | C ryoletters2002，23，： | 1 |
| 11 | Isozymes of glucose-6-phosphate dehylrogenase and NAD+-malate dehydrogenase in shoot-forming foliar discs of tobacco显示文摘 | SEENI S A GNANAM A | 1981 | Plant Cell Physiology1981，22，： | 1 |
| 12 | Therapeutic targeting ofangiotensinⅡreceptor type 1 to regulate androgen receptor inprostate cancer显示文摘 | Takahashi S Uemura H Seeni A | 2012 | Prostate2012，72，14： | 1 |
| 13 | Micropropagation of terrestrial hide Anorchids Anoectochilus sikkimensis and regalis显示文摘 | Cangaprasad A Latha PG Seeni S | | 0，，02： | 1 |
| 14 | Conservation through in vitro propagation and restoration of Mahonia leschenaultii, an endemic tree of the Western Ghats 显示文摘 | Radha R K Amy M V Seeni S | 2013 | scienceasia2013，219，39： | 1 |
| 15 | Structural mor- phology and in vitro toxicity studies of nano- and mi- cro-sized zinc oxide structures 显示文摘 | Ann L C Mahmud S Seeni A | 2015 | J Environ Chem Eng2015，3，： | 1 |
| 16 | Intraspecific variation in active principle content and isozymes of Andrographis paniculata Nees (Kalmegh) : a traditional hepatoprotective medicinal herb of In- dia显示文摘 | Sabu K K P Padmesh S Seeni | 2001 | J Med Aromat Plant Sci2001，23，4： | 1 |
| 17 | The use of RAPD in de- teeing genetic variability in Andrographis paniculata Ness: a hep- atoprotective drug显示文摘 | Padmesh P Sabu K K Seeni S | 1998 | Curr Sci1998，76，： | 1 |
| 18 | Foliar regeneration of the endangered Red Vanda, Renanthera imschootiana Rolfe (Orchidaceae) 显示文摘 | Seeni S Latha P G | 1992 | Plant Cell Tiss Org Cult1992，29，： | 1 |
| 19 | In vitro multiplication of Calophyllum apetalum(Clusiaceae),an endemic medicinal tree of the Western Ghats显示文摘 | Nair L G Seeni S | 2003 | Plant Cell Tissue and Organ Culture2003，75，2： | 1 |
| 20 | Foliar regeneration of the endangered Red Vanda, Renanthera imschootiana Rolfe (Orchidaceae)显示文摘 | S. Seeni P. G. Latha | 1992 | Plant Cell Tissue and Organ Culture1992，，3： | 1 |
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