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| 1 | Ageing affects chondroitin sulfates and their synthetic enzymes in the intervertebral disc显示文摘The depletion of chondroitin sulfates(CSs)within the intervertebral disc(IVD)during degenerative disc disease(DDD)results in a decrease in tissue hydration,a loss of fluid movement,cell apoptosis,a loss of nerve growth inhibition and ultimately,the loss of disc function.To date,little is known with regards to the structure and content of chondroitin sulfates(CSs)during IVD ageing.The behavior of glycosaminoglycans(GAGs),specifically CSs,as well as xylosyltransferase I(XT-I)and glucuronyltransferase I(GT-I),two key enzymes involved in CS synthesis as a primer of glycosaminoglycan(GAG)chain elongation and GAG synthesis in the nucleus pulposus(NP),respectively,were evaluated in a bovine ageing IVD model.Here,we showed significant changes in the composition of GAGs during the disc ageing process(6-month-old,2-year-old and 8-year-old IVDs representing the immature to mature skeleton).The CS quantity and composition of annulus fibrosus(AF)and NP were determined.The expression of both XT-I and GT-I was detected using immunohistochemistry.A significant decrease in GAGs was observed during the ageing process.CSs are affected at both the structural and quantitative levels with important changes in sulfation observed upon maturity,which correlated with a decrease in the expression of both XT-I and GT-I.A progressive switch of the sulfation profile was noted in both NP and AF tissues from 6 months to 8 years.These changes give an appreciation of the potential impact of CSs on the disc biology and the development of therapeutic approaches for disc regeneration and repair. | Estelle C Collin Oliver Carroll Michelle Kilcoyne Marianna Peroglio Eugene See Doris Hendig Mauro Alini Sibylle Grad Abhay Pandit | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 2 |
| 2 | Parametric sensor array calibration using measured steering vectors of uncertain locations显示文摘 | SEE C M S POH B K | 1999 | IEEE Trans SP1999，47，4： | 1 |
| 3 | Lithography using ultrathin resist films显示文摘 | See E G Pike C Bell S | 2000 | U J Vac Sci Technol B2000，18，： | 1 |
| 4 | Evaluation of time-varying availability in multi-echelon spare parts systems with passivation显示文摘 | H C Lau H Song C T See S Y Cheng | 2006 | European Operational Research2006，170，1： | 1 |
| 5 | Significance of serum uric acid levels on the risk of all-cause and cardiovascular mortality 显示文摘 | Kuo C F See L C Yu K H | 2013 | Rheumatology(Oxford)2013，52，1： | 1 |
| 6 | Symptomatic coronary obstruction due to Kawasaki disease in an adult 显示文摘 | Codispoti C Boyd S Sees D | 2008 | Ann Thorac Surg2008，85，3： | 1 |
| 7 | Visual outcome after surgery in extermelyhigh axial myopia 显示文摘 | Li C Y Chen Y C See L C | 2007 | Opbthslmol2007，39，1： | 1 |
| 8 | Protection against oxidative stress- induced insulin resistance in rat E6 muscle cells by mircomolar concentrations of alpha-lipoic acid 显示文摘 | MADDUX B A SEE W LAWRENCE J C | 2001 | Diabetes2001，50，2： | 1 |
| 9 | Dawsonite in the Greta CoalMeasures at Muswell-brook,New South Wales 显示文摘 | Loughnan F C See G T | 1967 | American Mineralogist1967，52，： | 1 |
| 10 | The formation and growth of intermetallics in composite solder显示文摘 | WU Y SEE J A POURAGHABAGHER C FOSTER L A MARSHALL J L | 1993 | J Electron Mater1993，22，4： | 1 |
| 11 | Evaluation of time-varying availability in multi-echelon spare parts systems with passivation 显示文摘 | Lau H C Song H See C T | 2006 | European Journal of Operational Research2006，170，1： | 1 |
| 12 | Genome-wide comparative diversity uncovers multiple targets of selection for improvement in hexaploid wheat landraces and cultivars 显示文摘 | Cavanagh CS Chao S Wang BE Huang BE Stephen S Kiani S Forrest K Saintenac C Brown-Guedira GL Akhunova A See D Bai G Pumphrey M Tomar L Wong D Kong S Reynolds M da Silva ML Bockelman H Talbert L Anderson JA Dreisigacker S Baenziger S Carter A Korzun V Morrell PL Dubcovsky J Morell MK Sorrells ME Hayden MJ Akhunov E | 2013 | PNAS2013，110，： | 1 |
| 13 | Sensor-array calibration using a maxlmum-likelihood approach显示文摘 | Ng B C See C M S | 1996 | 1EEE Trans A P1996，44，6： | 1 |
| 14 | Method for array calibration in high-resolution sensor array processing 显示文摘 | SEE C M S | 1995 | IEE ProcRadar Sonar Navig1995，142，3： | 1 |
| 15 | Sensor array calibration in the presence of mutual coupling and unknown sensor gains and phases显示文摘 | SEE C M S | 1994 | Electronics Letters1994，30，5： | 1 |
| 16 | Sensor array calibration in the presence of mutual coupling and unknown sensor gains and phases显示文摘 | See C M S | 1994 | ElectronLett1994，30，5： | 1 |
| 17 | Measurement of space-charge distributions in solid insulators under rapidly varying voltage using the high-voltage,high-speed pulsed electro-acoustic (PEA) apparatus显示文摘 | See A Fothergill J C Dissado L A | 2001 | Measurement Science & Technology2001，12，8： | 1 |
| 18 | Sensor array calibration using a maximum-likelihood approach显示文摘 | NG B C SEE C M S | 1996 | IEEE Transactions on Antennas and Propagation1996，44，6： | 1 |
| 19 | Symptomatic coronary obstruction due to Kawasaki disease in an adult 显示文摘 | Codispoti C Boyd S Sees D Conner W | 2008 | Ann Thorac Surg2008，85，3： | 1 |
| 20 | Parametric sensor array calibration using measured steering vectors of uncertain locations显示文摘 | See C M S Poh B K | 1999 | IEEE Trans SP1999，47，4： | 1 |
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