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| 1 | Evaluation of the effect of acupuncture on hand pain,functional deficits and health-related quality of life in patients with rheumatoid arthritis--A study protocol for a multicenter,double-blind,randomized clinical trial显示文摘BACKGROUND: Rheumatoid arthritis(RA) is a systemic inflammatory disease characterized by functional disability and pain. Although acupuncture is widely used, until now Western acupuncture studies on RA have not shown conclusive positive results. Acupuncture is regarded as a reflex therapy that has effects on the human autonomic nervous system. By establishing a traditional Chinese medicine(TCM) diagnosis first, the practitioner is able to choose acupoints according to the state of each individual patient.METHODS/DESIGN: We are interested if acupuncture, using a classical diagnostic procedure to allocate acupoints to the patient according to the Shang Han Lun theory, can be effective in relieving pain, improving hand function and increasing health-related quality of life in RA.The authors intend to harmonize TCM diagnosis according to clinical and genetic profiles. Patients with the TCM diagnosis of a so-called Turning Point syndrome will be followed up in a randomized, prospective, double-blind, placebo-controlled, multicenter and three-armed parallel-group study with a standardized treatment in order to optimize potential therapeutic effects of acupuncture on pain, strength and muscle function of patients with RA as well as the influence on inflammation and quality of life.DISCUSSION: The findings of this study will provide important clinical information about the feasibility and efficacy of acupuncture treatment for RA patients. In addition, it will explore the feasibility of further acupuncture research.TRIAL REGISTRATION NUMBER: Clinical Trials.gov Identifier NCT02553005. | Susana Seca Sebastian Kirch António S.Cabrita Henry J.Greten | 2016 | Journal of Integrative Medicine2016，14，3： | 14 |
| 2 | Effectiveness of Acupuncture on Pain, Physical Function and Health-Related Quality of Life in Patients with Rheumatoid Arthritis: A Systematic Review of Quantitative Evidence显示文摘Objective: To identify and synthesize the most recent available evidence of effectiveness of acupuncture on pain, physical function and health-related quality of life(HRQoL) in patients with rheumatoid arthritis(RA). Methods: A comprehensive search of 12 Western and Chinese databases was undertaken from their inception up to end of 2016. Randomized controlled trials(RCTs), concerning patients with RA treated with needle acupuncture, written in English, Portuguese, German or Chinese were included. Primary outcomes included pain, physical function and HRQoL. Secondary outcomes included morning stiffness, functional impairment, number of tender and swollen joints and serum concentrations of inflamatory markers. Methodological quality was assessed by three independent reviewers using the standardized critical appraisal instrument from the Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument. Results: Twenty-two studies met the inclusion criteria. Of those, 9 studies were excluded after assessment of their methodological quality. The remaining 13 original RCTs included 974 patients. Ten of these studies published in China, showed favorable statistical significant effects of acupuncture in relieving symptoms of RA compared with controls. Conclusions: Evidence suggests that acupuncture interventions may have a positive effect in pain relief, physical function and HRQo L in RA patients. However, due to the heterogeneity and methodologic limitations of the studies included in this systematic review, evidence is not strong enough to produce a best practice guideline. | Susana Seca Diana Miranda Daniela Cardoso Bernice Nogueira Henry J.Greten Antonio Cabrita Manuel Alves Rodrigues | 2019 | Chinese Journal of Integrative Medicine2019，25，9： | 11 |
| 3 | Diagnosis and Objective Pain Assessment of Traditional Chinese Medicine May Be Useful to Demonstrate Specific Effects of Acupuncture in Low Back Pain: A Prospective, Randomized, Controlled and Single Blinded Pre-study显示文摘Objective: To prove specific effects of acupuncture on chronic pain. It was speculated that the potential specific effectiveness of acupuncture could be better shown in more properly designed studies. Therefore, diagnoses of both Western medicine and traditional Chinese medicine (TCM) were used as inclusion criteria to allocate acupoints more precisely to the complaints of the patients. Secondly, objectively measurable parameters of pain relief in addition to usual Visual Analogue Scale (VAS) were chosen to quantify the effects of acupuncture. Methods: The study was prospective, randomized, controlled and single-blinded. Eighteen patients with chronic back pain and TCM diagnosis of a Taiyang/Yangming syndrome received one single session of acupuncture chosen according to TCM diagnosis or acupuncture on points outside the meridian system (controls). We evaluated pain via VAS and increased mobility via inclinometry of the back. Results: Although the sample size was small, there was a statistically significant improvement in pain and mobility in the intervention group (n=13), but not in the control group (n=5). The calculated sample size adequate power was lower for inclinometry than for VAS, indicating that VAS is less probable to discriminate acupuncture effects. Conclusion: Objectively measurable physical parameters such as the angle of flexion before and after acupuncture (inclinometry) may be more suitable to measure pain relief than subjective assessment by VAS in acupuncture studies. TCM diagnosis may be a helpful inclusion criterion in studies on acupuncture, so as to potentially allocate interventions better to the complaints of patients. | Susana Seca Paula Capelo Thomas Efferth Christoph Alexander Doenitz Sven Schroeder Ana Anjos Jorge Machado Henry Johannes Greten | 2013 | Journal of Acupuncture and Tuina Science2013，11，3： | 2 |
| 4 | Structuralcharacterization of the lignin from the nodes and intemodes ofArundo donaxreed 显示文摘 | Seca A M L Cavaleiro J A S Domingues F M J | 2000 | J Agric Food Chem2000，48，： | 1 |
| 5 | Seaweeds as preventive agents for cardiovascular diseases: from nutrients to functional foods显示文摘 | Cardoso S Pereira O Seca A | 2015 | Marine Drugs2015，13，11： | 1 |
| 6 | Structural characterization of the lignin from the nodes and internodes of Arundo donax reed显示文摘 | Seca A M Cavaleiro J A Domingues F M | 2000 | Journal of Agricultural&Food Chemistry2000，48，3： | 1 |
| 7 | Rotational atherectomyin the drug-eluting stent era: a recent single-center experi-ence显示文摘 | SECA L CACAO R SILVA J | 2012 | Kev Port Cardiol2012，31，1： | 1 |
| 8 | Application of biofilmreactors to improve ammonia oxidation in low nitrogen loadedwastewater显示文摘 | SECA I TORRES R DELRIO A V | 2011 | Water Science and Technology2011，63，9： | 1 |
| 9 | Effect of miR-128 in DNA damage of HL-60 acute myeloid leukemia cells 显示文摘 | Seca H Lima RT Almeida GM | 2014 | Curt Pharm Biotechnol2014，15，5： | 1 |
| 10 | Provision of inertial and primary frequency control services using offshore multiterminal HVDC networks显示文摘 | Silva B Moreira C L Seca L | 2012 | IEEE Transactions on Sustainable Energy2012，3，4： | 1 |
| 11 | The chemical composition of hexane extract from bark of Juniperus brevifolia显示文摘 | Seca A Silva A | 2008 | Natural Product Research2008，22，11： | 1 |
| 12 | The d iscovery pen ta studyadlrect stat in comparison of LDL-C value= an evalu at ionog rosuvastat in therapy com pared with atovastatin显示文摘 | Fon seca FAH RuizA S ilva JM | 2005 | CurrMedResOp in2005，21，13： | 1 |
| 13 | Targeting miR-21 induces autophagy and chemosensitivity of leukemia cells显示文摘 | Seca H Lima RT Lopes-Rodrigues V | | 0，，10： | 1 |
| 14 | EBV interferes with the sensi- tivity of Burkitt lymphoma Akata cells to etoposide 显示文摘 | Lima RT Seca H Soares P et ol | 2011 | J Cell Biochem2011，112，1： | 1 |
| 15 | A practical, efficient, and atom economic alter- native to the Wittig and Horner-Wadsworth-Emmons reac- tions for the synthesis of (E)-α, β-unsaturated esters from aldehydes 显示文摘 | Benjamin List Amo Doehring Mafia T Hechavarfia Fon- seca | 2006 | Tetrahedron2006，，62： | 1 |
| 16 | Targeting miR-21 induces autophagy and chemosensitivity of leukemia cells 显示文摘 | Seca H Lima RT Lopes-Rodrigues V | 2013 | Curt' Drug Targets2013，14，10： | 1 |
| 17 | Structural characterization of the lignin from the nodes and internodes of Arundo donax reed显示文摘 | SECA A M L CAVALEIRO J A S DOMINGUES F M J | 2000 | Journal of Agricultural and Food Chemistry2000，48，3： | 1 |
| 18 | Structural characterization of the lignin from the nodes and internodes of Arundo donax Reed显示文摘 | Seca A M L Cavaleiro J A S Domingues F M J | 2000 | Journal of Agriculture and Food Chemistry2000，48，3： | 1 |
| 19 | EBV interferes with the sensitivity of burkitt lymphoma akata cells to etopo-side显示文摘 | Lima RT Seca H Soares P | 2011 | J Cell Bio-chem2011，112，1： | 1 |
| 20 | Rotational atherectomy in the drug-eluting stent era: A recent single-center experience显示文摘 | Luís Seca Romeu Ca??o Joana Silva Paula Mota Marco Costa António Leit?o Marques | | Revista Portuguesa de Cardiologia (English Edition)0，，： | 1 |
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